MYO5A and MLPH

Number of citations of the paper that reports this interaction (PMID 11980908)
70

Data Source:
HPRD (in vitro, in vivo)

		MYO5A	MLPH
Gene Name		myosin VA (heavy chain 12, myoxin)	melanophilin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Photoreceptor Outer Segment Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Golgi Apparatus Cytosol Intermediate Filament Actin Filament Membrane Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Microtubule Plus-end Melanosome Actomyosin Neuron Projection Neuronal Cell Body Recycling Endosome Extracellular Vesicular Exosome	Stress Fiber Microtubule Organizing Center Dendrite Cortical Actin Cytoskeleton Microtubule Plus-end Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Microfilament Motor Activity Actin Binding Calcium Ion Binding Calmodulin Binding ATP Binding Rab GTPase Binding Poly(A) RNA Binding	Actin Binding Rab GTPase Binding Myosin V Binding Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Transport Exocytosis Post-Golgi Vesicle-mediated Transport Synaptic Transmission Visual Perception Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Insulin Secretion Melanocyte Differentiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Secretory Granule Localization Melanosome Transport Cellular Response To Insulin Stimulus Melanin Biosynthetic Process Odontogenesis Myelination Long-chain Fatty Acid Biosynthetic Process Cellular Protein Metabolic Process Synapse Organization Endoplasmic Reticulum Localization Membrane Organization Protein Localization To Plasma Membrane Regulation Of Golgi Organization	Protein Targeting Melanocyte Differentiation Melanosome Localization
Pathways		Peptide hormone metabolism Translocation of GLUT4 to the plasma membrane Insulin processing Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Prostate cancer ( 21743057)
Protein-Protein Interactions		11 interactors: BMF DLGAP1 DYNLL1 DYNLL2 MLPH NEFL PRPH RAB11A RAB27A TRIM2 TRIM3	3 interactors: MYO5A RAB27A RAB27B
Entrez ID		4644	79083
HPRD ID		01179	09409
Ensembl ID		ENSG00000197535	ENSG00000115648
Uniprot IDs		A8CDT9 F8WE88 G3V394 Q9UES4 Q9Y4I1	B3KSS2 G5E9G5 Q9BV36
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Multivesicular Body Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Melanosome Localization Exosomal Secretion Cellular Pigmentation Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Pigmentation Intrinsic Apoptotic Signaling Pathway Melanosome Transport Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Endosome Organization Pigment Granule Transport Vesicle Localization Establishment Of Melanosome Localization Melanocyte Differentiation Positive Regulation Of Intracellular Transport Intermediate Filament Cytoskeleton Organization Neuroepithelial Cell Differentiation Intermediate Filament-based Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Antigen Processing And Presentation Regulation Of Apoptotic Process Anatomical Structure Development Microtubule-based Process Regulation Of Protein Localization Rab Protein Signal Transduction Developmental Pigmentation Regulation Of Cell Death Apoptotic Signaling Pathway Positive Regulation Of Constitutive Secretory Pathway Multivesicular Body Assembly Regulation Of Multivesicular Body Size Complement-dependent Cytotoxicity Synaptic Target Recognition Positive Regulation Of Axonogenesis Developmental Process Positive Regulation Of Organelle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Organelle Localization Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Intracellular Transport Cytotoxic T Cell Degranulation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II	Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Cellular Pigmentation Multivesicular Body Sorting Pathway Pigmentation Protein Secretion Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Exocytosis Organelle Localization Melanocyte Differentiation Neuroepithelial Cell Differentiation Secretion By Cell Rab Protein Signal Transduction Developmental Pigmentation Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Secretion Vesicle Docking Membrane Docking Positive Regulation Of Constitutive Secretory Pathway Complement-dependent Cytotoxicity Regulation Of Exocytosis Cellular Protein Localization Protein Transport Vesicle-mediated Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Establishment Of Protein Localization Ras Protein Signal Transduction Intracellular Transport Endoplasmic Reticulum Localization Vesicle Transport Along Actin Filament Exosomal Secretion Protein Localization Positive Regulation Of Secretion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Establishment Of Localization In Cell Natural Killer Cell Degranulation Regulation Of Vesicle-mediated Transport Locomotion Involved In Locomotory Behavior Endomembrane System Organization Secretory Granule Localization T Cell Mediated Cytotoxicity Cellular Localization Epithelial Cell Differentiation Synaptic Transmission
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	blue breeds californian castor checkered coat colour colours cosegregation dilute diluted eumelanic fairy frameshift grey griscelli indel lod marburg melanophilin pearly pheomelanic pigmentation pigmentations rab27a rex segregating sib vienna
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	blue breeds californian castor checkered coat colour colours cosegregation dilute diluted eumelanic fairy frameshift grey griscelli indel lod marburg melanophilin pearly pheomelanic pigmentation pigmentations rab27a rex segregating sib vienna
Tagcloud (Intersection) ?