DYNLL1 and MYO10

Number of citations of the paper that reports this interaction (PMID 14760703)
24

Data Source:
HPRD (in vitro)

		DYNLL1	MYO10
Gene Name		dynein, light chain, LC8-type 1	myosin X
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Cell Cortex Myosin Complex Lamellipodium Filopodium Membrane Filopodium Tip Neuron Projection Neuronal Cell Body
	Molecular Function	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity	Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Spectrin Binding Actin-dependent ATPase Activity Actin Filament Binding Plus-end Directed Microfilament Motor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Axon Guidance Metabolic Process Regulation Of Cell Shape Positive Regulation Of Cell-cell Adhesion Cytoskeleton-dependent Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Regulation Of Filopodium Assembly
Pathways		Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis	Axon guidance Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A	6 interactors: ACTA1 CALM1 CALML3 DYNLL1 ITGB5 PLA2G10
Entrez ID		8655	4651
HPRD ID		03334	03283
Ensembl ID		ENSG00000088986	ENSG00000145555
Uniprot IDs		P63167 Q6FGH9	E7EPL7 Q9HD67
PDB IDs		1CMI 3ZKE 3ZKF	2LW9 3AU4 3AU5 3PZD
Enriched GO Terms of Interacting Partners?		Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process	Muscle Contraction Muscle System Process Substantia Nigra Development Neural Nucleus Development Midbrain Development Actin Cytoskeleton Organization Actin Filament-based Process Lysophospholipid Transport Actomyosin Structure Organization Positive Regulation Of Transport Multicellular Organismal Development Anatomical Structure Development Skeletal Muscle Fiber Adaptation Anatomical Structure Morphogenesis Developmental Process Positive Regulation Of Ion Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Antigen Processing And Presentation Of Peptide Antigen Negative Regulation Of Cholesterol Efflux Regulation Of High Voltage-gated Calcium Channel Activity Cytoskeleton Organization Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Arachidonic Acid Secretion Skeletal Muscle Thin Filament Assembly Organelle Organization Antigen Processing And Presentation Regulation Of Arachidonic Acid Secretion Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Actin Filament Organization Skeletal Myofibril Assembly Response To Metal Ion Skeletal Muscle Adaptation Alcohol Metabolic Process Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Cholesterol Transport Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Transport Negative Regulation Of Phosphorylation Positive Regulation Of Phosphoprotein Phosphatase Activity Phosphatidylinositol Acyl-chain Remodeling Positive Regulation Of Prostaglandin Secretion Stress Fiber Assembly Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Regulation Of Intracellular Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Tagcloud ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation
Tagcloud (Difference) ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	adenocarcinoma aggressive attenuated carcinomas dissemination driven ductal edges engines filopodia inducing integrin integrins invasion metastasis motor mutant myosin predominantly profiles promoted promoting protrusions serve sets specialized tip tp53 upregulation
Tagcloud (Intersection) ?