MYO5A and BMF

Number of citations of the paper that reports this interaction (PMID 11546872)
99

Data Source:
BioGRID (pull down)

		MYO5A	BMF
Gene Name		myosin VA (heavy chain 12, myoxin)	Bcl2 modifying factor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Photoreceptor Outer Segment Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Golgi Apparatus Cytosol Intermediate Filament Actin Filament Membrane Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Microtubule Plus-end Melanosome Actomyosin Neuron Projection Neuronal Cell Body Recycling Endosome Extracellular Vesicular Exosome	Acrosomal Vesicle Mitochondrial Outer Membrane Cytosol Plasma Membrane Myosin Complex
	Molecular Function	Microfilament Motor Activity Actin Binding Calcium Ion Binding Calmodulin Binding ATP Binding Rab GTPase Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Transport Exocytosis Post-Golgi Vesicle-mediated Transport Synaptic Transmission Visual Perception Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Insulin Secretion Melanocyte Differentiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Secretory Granule Localization Melanosome Transport Cellular Response To Insulin Stimulus Melanin Biosynthetic Process Odontogenesis Myelination Long-chain Fatty Acid Biosynthetic Process Cellular Protein Metabolic Process Synapse Organization Endoplasmic Reticulum Localization Membrane Organization Protein Localization To Plasma Membrane Regulation Of Golgi Organization	Apoptotic Process Positive Regulation Of Protein Homooligomerization Anoikis Positive Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Peptide hormone metabolism Translocation of GLUT4 to the plasma membrane Insulin processing Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Activation of BMF and translocation to mitochondria Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			Dehydroepiandrosterone sulphate levels ( 21533175) Ewing sarcoma ( 22327514)
Protein-Protein Interactions		11 interactors: BMF DLGAP1 DYNLL1 DYNLL2 MLPH NEFL PRPH RAB11A RAB27A TRIM2 TRIM3	15 interactors: BCL2 BCL2A1 BCL2L1 BCL2L2 CXCL9 DYNLL1 DYNLL2 MAPK8 MCL1 MYO5A NNMT REL SEC14L4 TCF12 TFIP11
Entrez ID		4644	90427
HPRD ID		01179	05881
Ensembl ID		ENSG00000197535	ENSG00000104081
Uniprot IDs		A8CDT9 F8WE88 G3V394 Q9UES4 Q9Y4I1	Q96LC9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Multivesicular Body Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Melanosome Localization Exosomal Secretion Cellular Pigmentation Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Pigmentation Intrinsic Apoptotic Signaling Pathway Melanosome Transport Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Endosome Organization Pigment Granule Transport Vesicle Localization Establishment Of Melanosome Localization Melanocyte Differentiation Positive Regulation Of Intracellular Transport Intermediate Filament Cytoskeleton Organization Neuroepithelial Cell Differentiation Intermediate Filament-based Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Transport Antigen Processing And Presentation Regulation Of Apoptotic Process Anatomical Structure Development Microtubule-based Process Regulation Of Protein Localization Rab Protein Signal Transduction Developmental Pigmentation Regulation Of Cell Death Apoptotic Signaling Pathway Positive Regulation Of Constitutive Secretory Pathway Multivesicular Body Assembly Regulation Of Multivesicular Body Size Complement-dependent Cytotoxicity Synaptic Target Recognition Positive Regulation Of Axonogenesis Developmental Process Positive Regulation Of Organelle Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Organelle Localization Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Intracellular Transport Cytotoxic T Cell Degranulation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II	Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Process Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Programmed Cell Death Cell Death Death Regulation Of Cell Death Negative Regulation Of Anoikis Regulation Of Signaling Regulation Of Anoikis Positive Regulation Of Intracellular Transport Positive Regulation Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Localization Regulation Of Neuron Death Cellular Response To Stimulus Regulation Of Establishment Of Protein Localization Response To Stimulus Response To Organic Substance Response To Cytokine Melanin Metabolic Process Positive Regulation Of Transport
Tagcloud ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	70z bcgf begin bpa call chromatographic die discrete etc glycoproteins glycosylated hcgf helper heterogeneously ig implying lymphokine lymphokines mcgf mildly permeation psf purifies purify splenic supernatants synthesize variously wehi
Tagcloud (Difference) ?		agouti camk2g cd47 chances clstn2 consonant enpp1 epha5a gad2 gria3 grin2b kif minipumps negr1 neuroplasticity ntrk2 ntrk3 ppp3r1 prdx1 predecessors serotonine slc2a4 sv2b syn2 synaptogenesis synj2 therapeutical venlafaxine vlx	70z bcgf begin bpa call chromatographic die discrete etc glycoproteins glycosylated hcgf helper heterogeneously ig implying lymphokine lymphokines mcgf mildly permeation psf purifies purify splenic supernatants synthesize variously wehi
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