DYNLL1 and KANK2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DYNLL1	KANK2
Gene Name		dynein, light chain, LC8-type 1	KN motif and ankyrin repeat domains 2
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip	Cytoplasm Mitochondrion
	Molecular Function	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS			HDL cholesterol ( 23505323)
Protein-Protein Interactions		77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A	22 interactors: ABI3 AES CCDC33 CCDC36 CEP70 CSNK2A1 DYNLL1 EIF4E FHL2 GOLGA2 GPSM1 LMO1 LMO2 LMO4 MAGEB4 MOB1A NCOA1 NOS3 PSEN1 STAC TXLNA VPS52
Entrez ID		8655	25959
HPRD ID		03334	12463
Ensembl ID		ENSG00000088986	ENSG00000197256
Uniprot IDs		P63167 Q6FGH9	Q63ZY3
PDB IDs		1CMI 3ZKE 3ZKF	4HBD
Enriched GO Terms of Interacting Partners?		Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process	System Development Organ Development Anatomical Structure Morphogenesis Multicellular Organismal Development Anatomical Structure Development Regulation Of Apoptotic Process Regulation Of Cell Death Tube Development Embryo Development Regulation Of Protein Binding Developmental Process Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Androgen Receptor Signaling Pathway Embryonic Organ Development Cellular Response To Extracellular Stimulus Gene Expression Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Cajal-Retzius Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Beta-amyloid Formation Negative Regulation Of Protein Binding Thymus Development Macromolecule Biosynthetic Process Positive Regulation Of Apoptotic Process Regulation Of Binding Positive Regulation Of Programmed Cell Death Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Biosynthetic Process Cell Cycle Phase Transition Positive Regulation Of Cell Death Transcription, DNA-templated Wnt Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Protein Catabolic Process Biosynthetic Process RNA Biosynthetic Process Smooth Muscle Hyperplasia Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Ectodermal Digestive Tract Development Rhythmic Process Mitotic Cell Cycle Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Atrial Cardiac Muscle Cell Development Regulation Of Cellular Response To Drug
Tagcloud ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Intersection) ?