DYNLL1 and GLUD1

Number of citations of the paper that reports this interaction (PMID 14760703)
24

Data Source:
HPRD (in vitro)

		DYNLL1	GLUD1
Gene Name		dynein, light chain, LC8-type 1	glutamate dehydrogenase 1
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity	Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding ADP Binding NAD+ Binding Leucine Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Glutamate Biosynthetic Process Glutamate Catabolic Process Glutamine Metabolic Process Cellular Amino Acid Biosynthetic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Tricarboxylic Acid Metabolic Process
Pathways		Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis	Amino acid synthesis and interconversion (transamination) Metabolism of amino acids and derivatives
Drugs			L-Glutamic Acid NADH Hexachlorophene Nicotinamide-Adenine-Dinucleotide Adenosine-5\'-Diphosphate Guanosine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A	11 interactors: ASGR2 CRP DYNLL1 GOT2 HPX LSM1 NR4A1 ORM1 SEC62 STAT5A VTN
Entrez ID		8655	2746
HPRD ID		03334	11748
Ensembl ID		ENSG00000088986	ENSG00000148672
Uniprot IDs		P63167 Q6FGH9	B3KV55 E9KL48 P00367
PDB IDs		1CMI 3ZKE 3ZKF	1L1F 1NR1
Enriched GO Terms of Interacting Partners?		Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process	Regulation Of Immune System Process 2-oxoglutarate Metabolic Process Regulation Of Immune Response Oxaloacetate Metabolic Process Transport Acute-phase Response Endocytosis Regulation Of Humoral Immune Response Positive Regulation Of Mast Cell Differentiation Receptor-mediated Endocytosis Acute Inflammatory Response Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process To 2-oxoglutarate Glutamate Catabolic Process To Aspartate Aspartate Biosynthetic Process Regulation Of Mast Cell Differentiation Fumarate Metabolic Process Development Of Secondary Male Sexual Characteristics Immune System Process Aspartate Catabolic Process 4-hydroxyproline Catabolic Process Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Hormone-mediated Signaling Pathway Response To Ethanol Negative Regulation Of Mast Cell Apoptotic Process L-kynurenine Metabolic Process Creatinine Metabolic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Mast Cell Proliferation Positive Regulation Of Immune Response Glutamate Catabolic Process Isoleucine Metabolic Process Allantoin Metabolic Process Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Vesicle-mediated Transport Positive Regulation Of Innate Immune Response Taurine Metabolic Process Aspartate Metabolic Process Positive Regulation Of Gamma-delta T Cell Differentiation Posttranslational Protein Targeting To Membrane Negative Regulation Of Vasodilation Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Erythrocyte Differentiation Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Prolactin Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation
Tagcloud ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	alcoholics automatic brains caudate cortices dorsal epsilon excitatory executive gaba gamma1 glud2 glun2a glutamate ionotropic mortem movements mrnas outputs prominently putamen qpcr rho2 seeking striatal striatum thinking underlie voluntarily
Tagcloud (Difference) ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	alcoholics automatic brains caudate cortices dorsal epsilon excitatory executive gaba gamma1 glud2 glun2a glutamate ionotropic mortem movements mrnas outputs prominently putamen qpcr rho2 seeking striatal striatum thinking underlie voluntarily
Tagcloud (Intersection) ?