MYO5A and RPH3A

Number of citations of the paper that reports this interaction (PubMedID 21349835)
66

Data Source:
BioGRID (pull down)

		MYO5A	RPH3A
Description		myosin VA	rabphilin 3A
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Cytosol Actin Filament Actin Cytoskeleton Membrane Myosin Complex Growth Cone Cytoplasmic Vesicle Vesicle Filopodium Tip Insulin-responsive Compartment Melanosome Neuron Projection Recycling Endosome Extracellular Exosome	Plasma Membrane Synaptic Vesicle Membrane Extrinsic Component Of Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Microfilament Motor Activity Nucleotide Binding RNA Binding Cytoskeletal Motor Activity Actin Binding Catalytic Activity Protein Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity Small GTPase Binding Actin Filament Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Lipid Binding Selenium Binding Small GTPase Binding Phosphate Ion Binding Protein-containing Complex Binding Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Post-Golgi Vesicle-mediated Transport Endocytosis Actin Filament Organization Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Melanosome Transport Cellular Response To Insulin Stimulus Protein Localization To Plasma Membrane Regulation Of Golgi Organization	Intracellular Protein Transport Protein Transport Synaptic Vesicle Priming Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Mean platelet volume ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736)	Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Chloride levels ( 29403010) Coronary artery disease ( 32469254) Epilepsy ( 33913524) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Low density lipoprotein cholesterol levels ( 29403010 32154731) Low HDL-cholesterol levels ( 31006500) Platelet count ( 22139419) Serum uric acid levels ( 32514006) Spleen volume ( 34128465) Urate levels ( 31578528)
Interacting Genes		20 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 ERG KIF5B MLPH NDEL1 NEFL PDE4B PRPH RAB11A RAB27A RAB3A RPH3A TRIM2 TRIM3 USP7	13 interacting genes: ADD2 CASK CFAP298 GCH1 MYO5A NRXN1 RAB15 RAB27A RAB27B RAB3A RAB3B RAB8A YWHAH
Entrez ID		4644	22895
HPRD ID		01179	15273
Ensembl ID		ENSG00000197535	ENSG00000089169
Uniprot IDs		A0A8I5KTF1 A0A8J8YWI7 A8CDT9 Q9UES4 Q9Y4I1	Q9Y2J0
PDB IDs		4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ
Enriched GO Terms of Interacting Partners?		Establishment Of Vesicle Localization Vesicle Localization Establishment Of Organelle Localization Organelle Localization Axon Cytoplasm Myosin V Binding Establishment Of Localization In Cell Retrograde Axonal Transport Protein-containing Complex Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Pigment Granule Localization Regulation Of Transport Centrosome Centrosome Localization Exosomal Secretion Synaptic Vesicle Transport Microtubule Associated Complex Synaptic Vesicle Membrane Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Microtubule-based Process Positive Regulation Of Regulated Secretory Pathway Lysosome Localization Transport Along Microtubule Vesicle Axonal Transport Neurofilament Cytoskeleton Organization Microtubule-based Movement Cytoskeleton-dependent Intracellular Transport Cytosol Microtubule-based Transport Axo-dendritic Transport Positive Regulation Of Exocytosis Cytoskeleton Organelle Transport Along Microtubule Protein Transport Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Organelle Organization Secretory Granule Regulation Of Intracellular Transport Intracellular Transport Regulation Of Cellular Localization Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane	Myosin V Binding GTPase Activity GTP Binding Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Intracellular Protein Localization Establishment Of Protein Localization Vesicle GDP Binding Protein Transport Establishment Of Localization In Cell Positive Regulation Of Exocytosis Nucleotide Binding Vesicle Localization Regulation Of Vesicle-mediated Transport Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Transport Protein Localization To Synapse Vesicle-mediated Transport Organelle Localization G Protein Activity Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Protein Localization To Cell Junction Synaptic Vesicle Clustering Vesicle-mediated Transport In Synapse Melanosome Secretory Granule Positive Regulation Of Secretion By Cell Establishment Of Vesicle Localization Trans-Golgi Network Transport Vesicle Positive Regulation Of Secretion Hydrolase Activity GTP-dependent Protein Binding Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Synaptic Vesicle Membrane Synaptic Vesicle Melanosome Localization Pigment Granule Localization Exocytic Vesicle Endosome Multivesicular Body Membrane Late Endosome
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