AES and SCNM1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AES	SCNM1
Gene Name		amino-terminal enhancer of split	sodium channel modifier 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleolus Nuclear Speck
	Molecular Function	Transcription Corepressor Activity Protein Binding	Enzyme Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis	MRNA Processing RNA Splicing
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt repression of WNT target genes APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		138 interactors: ABI2 AEN AR ARHGAP32 ATN1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 C6orf165 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CIB3 CPSF7 CRACR2A CRX CTAGE5 DDX6 DGCR6 DIP2A EAF1 EIF4E2 FAM124A FAM124B FBF1 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GOLGA2 GORASP2 GRB2 GTF2E1 HMGB1 HNF1A HNRNPF HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NL NUDT22 OLIG3 OSGIN1 PARVG POU2F1 PPP1R16A PRDM1 PRKAA1 PRKAA2 PRPF31 PRR3 PTRH2 QARS RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 TBX3 TCF4 TMCC2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576	43 interactors: AES BLZF1 CCDC33 CCDC85B CDR2 CEP44 GOLGA2 HMG20A IKZF1 INCA1 KRT31 KRT38 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 LZTS2 MCM6 MEOX2 MID2 MIPOL1 MKRN3 NAB2 NOTCH2NL PDE4DIP PLSCR1 PNMA1 PNMA2 PRNP RINT1 RPGRIP1 SPERT SSX2IP SYCE1 TRAF1 TRIM27 TRIM37 TRIM42 TRIM54 UBXN11 ZBTB14 ZDHHC17
Entrez ID		166	79005
HPRD ID		02556	12162
Ensembl ID		ENSG00000104964	ENSG00000163156
Uniprot IDs		Q08117 Q8WY48	Q9BWG6
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Multicellular Organismal Development Cellular Metabolic Process Developmental Process Anatomical Structure Development Positive Regulation Of Cellular Biosynthetic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Organ Morphogenesis Embryo Development Tissue Development RNA Processing RNA Splicing In Utero Embryonic Development Regulation Of Cell Death Organ Development	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Viral Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Cell Cycle Negative Regulation Of Interleukin-2 Production Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Viral Transcription Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Release From Host Cell Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Viral Process Positive Regulation Of Neutrophil Differentiation Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Transcription, DNA-templated Cellular Component Assembly RNA Biosynthetic Process Negative Regulation Of Protein Binding Negative Regulation Of Interleukin-2 Secretion Cellular Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of Viral Transcription Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Histone H2A-K119 Monoubiquitination Macromolecule Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Anoikis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Ubiquitination Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Protein Modification By Small Protein Conjugation Regulation Of Growth Negative Regulation Of Protein Phosphorylation Negative Regulation Of Binding Positive Regulation Of Cell Death Intraciliary Transport Involved In Cilium Morphogenesis
Tagcloud ?		auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
Tagcloud (Difference) ?		auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps
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