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TLE5 and RELA
Number of citations of the paper that reports this interaction (PubMedID
10660609
)
0
Data Source:
BioGRID
(two hybrid, pull down, affinity chromatography technology, pull down)
HPRD
(in vivo, two hybrid, in vitro)
TLE5
RELA
Description
TLE family member 5, transcriptional modulator
RELA proto-oncogene, NF-kB subunit
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytoplasm
Cytosol
Protein-containing Complex
NF-kappaB P50/p65 Complex
Synapse
NF-kappaB Complex
Glutamatergic Synapse
Molecular Function
Transcription Corepressor Activity
Protein Binding
Identical Protein Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Enzyme Binding
Protein Kinase Binding
Chromatin DNA Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Phosphate Ion Binding
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NF-kappaB Binding
Ankyrin Repeat Binding
General Transcription Initiation Factor Binding
DNA-binding Transcription Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Gene Expression
Wnt Signaling Pathway
Regulation Of Growth
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Response To Cytokine Stimulus
Response To Interleukin-1
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Anoikis
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cytokine Production
Liver Development
Hair Follicle Development
Defense Response To Tumor Cell
Response To Ischemia
Chromatin Organization
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Defense Response
Inflammatory Response
Cellular Defense Response
Neuropeptide Signaling Pathway
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Response To Bacterium
Animal Organ Morphogenesis
Response To UV-B
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Positive Regulation Of Schwann Cell Differentiation
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Signal Transduction Involved In Regulation Of Gene Expression
Protein Catabolic Process
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Response To Progesterone
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Response To Insulin
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Protein Sumoylation
Response To Cobalamin
Response To Cytokine
Toll-like Receptor 4 Signaling Pathway
Intracellular Signal Transduction
Cellular Response To Hepatocyte Growth Factor Stimulus
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Vascular Endothelial Growth Factor Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Prolactin Signaling Pathway
Negative Regulation Of Protein Catabolic Process
Response To Hydrogen Peroxide
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Amino Acid
Response To Morphine
Innate Immune Response
Response To Ethanol
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Inflammatory Response
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Response To CAMP
Defense Response To Virus
Cellular Response To Hydrogen Peroxide
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Nicotine
Cellular Response To Interleukin-1
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Postsynapse To Nucleus Signaling Pathway
Antiviral Innate Immune Response
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Positive Regulation Of Amyloid-beta Formation
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Cellular Response To Angiotensin
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of MiRNA Metabolic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Repression of WNT target genes
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1-dependent IKK and NF-kappa-B activation
Interleukin-1 processing
SUMOylation of immune response proteins
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Regulation of NFE2L2 gene expression
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Drugs
Glucosamine
Dimethyl fumarate
SC-236
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Inflammatory bowel disease (
23128233
)
LDL cholesterol levels (
32203549
)
Sensation seeking (
30718321
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Urate levels (
31578528
31985003
)
Interacting Genes
363 interacting genes:
ABI2
ACTMAP
AEN
AGR2
AIRIM
AKAP8L
ANAPC11
ANKRD11
AR
ARHGAP32
ARX
ASB3
ATN1
ATOSB
ATP6V0D1
BAG4
BAHD1
BCL6
BHLHE40
BIRC7
BPIFA1
BYSL
C10orf55
C14orf119
C1orf216
C1orf94
C7orf57
CABP2
CABP4
CABP5
CALCOCO2
CAPN1
CARD9
CATSPERT
CCDC120
CCDC57
CCL7
CCNJL
CCNK
CFAP206
CFAP68
CIB3
CLIC3
CLIP3
CNFN
COA7
CPSF7
CRACR2A
CSNK1E
CSNK2A1
CSTF2
CSTF2T
CT55
CTBP2
CYSRT1
DAZAP2
DCUN1D1
DDX6
DGCR6
DIP2A
DMRT2
DMRT3
DMRTB1
DNMT3L
DOK6
DVL2
DVL3
DYDC1
EAF1
EAF2
EFEMP2
EFHC1
EIF1AD
EIF4E2
ERF
EXOSC5
EYA2
FAM124A
FAM124B
FAM168B
FAM217B
FAM90A1
FANCG
FBF1
FCHSD2
FHL3
FOSB
FOXD2
FOXN1
FOXP2
FRS3
FSD2
FXR1
FXR2
GABARAP
GATA1
GCC1
GEM
GFAP
GFI1B
GIGYF1
GLIS2
GLRX3
GOLGA2
GOLGA6L9
GORASP2
GPANK1
GPATCH2L
GRAP2
GRB2
GRN
GTF2E1
GYS1
HDAC4
HDHD3
HELT
HEXIM2
HGS
HHEX
HMGB1
HNF1A
HNRNPF
HNRNPH2
HNRNPK
HNRNPLL
HOMEZ
HOXA1
HOXB5
HOXC8
HOXC9
IKZF3
INO80B
INO80E
INPP5J
IRX2
IRX6
KANK2
KDM1A
KIFC3
KLF1
KLF4
KLHDC7B
KRT13
KRT15
KRT31
KRT34
KRT35
KRT40
KRTAP1-1
KRTAP10-11
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
KRTAP7-1
KRTAP8-1
L3MBTL2
LDLR
LDOC1
LENG8
LINC00526
LMO1
LMO2
LMO4
LSM2
LZTS2
MAGOHB
MAPK1
MAPK14
MAPRE3
MBNL1
MCRS1
MDFI
MECOM
MED12L
MED25
MED31
MED4
MEIS3
MFAP1
MIA2
MIIP
MKRN3
MLH1
MLLT6
MLX
MORF4L1
MORF4L2
MSS51
MSX1
MSX2
MTUS2
MVP
MYF5
MYH7B
MYO15B
MYOG
NAB2
NAF1
NBPF19
NCDN
NDOR1
NDUFB7
NEK6
NLGN3
NOTCH2NLA
NTAQ1
NUDT22
NUTF2
NUTM1
OLIG3
OSGIN1
OXER1
P4HA3
PARVG
PATZ1
PCBP1
PCSK5
PFDN5
PHF1
PICK1
PITX1
PITX2
PLAGL1
POLR1C
POU2F1
PPP1R16A
PPP1R16B
PRDM1
PRDM14
PRDM6
PRKAA1
PRKAA2
PRKAB2
PROP1
PRPF31
PRR3
PRR35
PSMB1
PSMB4
PSMF1
PTRH2
QARS1
RAD51D
RBM10
RBPMS
REL
RELA
RFX6
RHOXF2
RIBC1
RIMBP3
RNF31
RORB
RPL18A
RUNX1
RUSC1
SAT1
SCNM1
SDCBP
SERTAD3
SET
SF3B4
SH2B2
SH3GL3
SHFL
SHISA6
SIX1
SIX2
SIX3
SIX6
SKIL
SKP2
SMAD3
SMAD4
SMARCB1
SMARCD1
SNCAIP
SNRPA
SNRPC
SOHLH1
SPATA25
SPG21
SPMIP9
SRPK2
SSC4D
STK16
STX11
SUFU
SUPT5H
TBX3
TBX6
TCEANC
TCF4
TCF7L2
TEAD4
TENT5B
TFAP2D
THAP7
TIGD3
TMCC2
TNS2
TOX3
TRAF1
TRAF2
TRIB3
TRIM26
TRIM27
TRIM41
TRIP6
TRMT2A
TSC1
TSC22D4
TSEN15
TSGA10
TSGA10IP
TSSK3
TTC23
U2AF2
UBAP2
UBE2H
UBL5
UBXN11
USP2
USP54
VEZF1
VGLL1
VIM
VPS37B
VPS37C
YPEL3
YTHDF1
ZBTB16
ZBTB24
ZBTB47
ZFHX3
ZGPAT
ZIC1
ZMYND12
ZNF330
ZNF34
ZNF383
ZNF408
ZNF414
ZNF417
ZNF467
ZNF48
ZNF503
ZNF524
ZNF576
ZNF688
ZNF792
ZNF835
ZRANB1
205 interacting genes:
AATF
ACTL6A
AGO1
AHR
AKAP8
APBA2
AR
ARNT
ASB9
AURKA
BANP
BATF2
BRCA1
BRMS1
BTK
BTRC
C1QB
CALM1
CAMK4
CARM1
CCL5
CCND2
CDC34
CDK9
CEBPB
CEBPD
CHEK1
CHUK
CNNM3
COL2A1
COMMD1
COMMD10
CREBBP
CSNK1G1
CSNK2A1
CSNK2A2
DDC
DDX1
DHX9
DNAJA3
DNMT3L
ECSIT
EEF1D
EGR1
EP300
EPHA2
ESR1
ETHE1
EZH2
FAF1
FBP1
FBXW2
FKBP11
FOS
FUS
GLIS1
GOPC
GTF2B
HDAC1
HDAC2
HDAC3
HEXIM1
HMGA2
HMGB1
HSPA4
IGF1R
IKBKB
IKBKE
ING4
IRAK1BP1
IRF1
IRF2
IRF3
IRF8
IRF9
ISL1
JUN
KAT2A
KAT2B
KAT5
KDM2A
KEAP1
KPNA2
LATS2
LMO2
MAP2K6
MAP3K7
MAP3K8
MAPK10
MAPK14
MED15
MED23
MED7
MEN1
MEOX2
MKRN2
MST1R
MTPN
MX1
MYC
NCOA3
NCOA6
NCOR2
NFE2L2
NFKB1
NFKB2
NFKBIA
NFKBIB
NFKBIE
NKRF
NKX2-1
NOTCH1
NPM1
NR3C1
OVOL2
PARP1
PDCD11
PGR
PIAS1
PIAS3
PIK3CA
PIN1
PKM
PLA2G4A
PLK1
PML
POU2F1
POU6F2
PPARA
PPP1R13L
PPP2CA
PPP2CB
PPP2R1B
PPP4C
PRKACA
PRKCZ
PRMT1
PRTN3
PSMD10
RAD51
RASSF1
RBCK1
REL
RELB
REPS2
RFC1
RIOK2
RNASE1
RNF25
RPL13
RPL23
RPS3
RPS6KA5
RTN4IP1
RXRA
SAT1
SETD7
SIN3A
SIRT1
SMAD3
SNIP1
SNRNP70
SOCS1
SOCS6
SORD
SP1
SRF
STAT1
STAT3
STAT6
SUOX
TAF1
TAF11
TAF4B
TAF6
TAF9
TBK1
TBP
TCAP
TCF4
TERT
TGM2
TLE5
TNIP2
TP53
TP53BP1
TP53BP2
TRIB3
TRIM55
TRIM63
TRIP4
TSC22D3
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2H
UBE2L3
UNC5CL
USF2
USP7
ZBTB7A
ZBTB7B
Entrez ID
166
5970
HPRD ID
02556
01241
Ensembl ID
ENSG00000104964
ENSG00000173039
Uniprot IDs
Q08117
A0A087X0W8
Q04206
PDB IDs
1NFI
2LSP
2O61
3GUT
3QXY
3RC0
4KV1
4KV4
5U4K
5URN
6NV2
6QHL
6QHM
6YOW
6YOX
6YOY
6YP2
6YP3
6YP8
6YPL
6YPY
6YQ2
7BI3
7BIQ
7BIW
7BIY
7BJB
7BJF
7BJL
7BJW
7BKH
7LET
7LEU
7LF4
7NJ9
7NJB
7NK3
7NK5
7NLA
7NLE
7NM1
7NM3
7NM9
7NMH
7NQP
7NR7
7NSV
7NV4
7NVI
7NWS
7NXS
7NXT
7NXW
7NXY
7NY4
7NYE
7NYF
7NYG
7NZ6
7NZG
7NZK
7NZV
7O34
7O3A
7O3F
7O3P
7O3Q
7O3R
7O3S
7O57
7O59
7O5A
7O5C
7O5D
7O5F
7O5G
7O5O
7O5P
7O5S
7O5U
7O5X
7O6F
7O6G
7O6I
7O6J
7O6K
7O6M
7O6O
Enriched GO Terms of Interacting Partners
?
Protein Binding
Regulation Of RNA Metabolic Process
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
Positive Regulation Of RNA Metabolic Process
DNA-binding Transcription Factor Activity
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Intermediate Filament
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
DNA Binding
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Sequence-specific DNA Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of Metabolic Process
Keratin Filament
Identical Protein Binding
Transcription Cis-regulatory Region Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Cellular Developmental Process
Cell Differentiation
Pattern Specification Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Response To Stress
Chromatin
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Response To Stress
Macromolecule Metabolic Process
DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Chromatin Remodeling
Rhythmic Process
Negative Regulation Of Signal Transduction
Nucleic Acid Metabolic Process
Cytosol
Negative Regulation Of Signaling
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Tagcloud (Intersection)
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