AES and ABI2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		AES	ABI2
Gene Name		amino-terminal enhancer of split	abl-interactor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Cytoskeleton Lamellipodium Filopodium SCAR Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding	DNA Binding Protein Binding Cytoskeletal Adaptor Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding Protein Complex Binding Rac GTPase Binding Proline-rich Region Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Organ Morphogenesis Negative Regulation Of Gene Expression Wnt Signaling Pathway Cellular Response To Extracellular Stimulus Negative Regulation Of Protein Binding Regulation Of Growth Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Response To Cytokine Stimulus Response To Interleukin-1 Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Anoikis	Movement Of Cell Or Subcellular Component Cytoskeleton Organization Actin Polymerization Or Depolymerization Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Signaling by Wnt repression of WNT target genes APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer truncations of AMER1 destabilize the destruction complex	Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Butyrylcholinesterase levels ( 21862451) Subclinical atherosclerosis traits (other) ( 17903303)
Protein-Protein Interactions		138 interactors: ABI2 AEN AR ARHGAP32 ATN1 BAHD1 BCL6 BHLHE40 BIRC7 BYSL C1orf109 C1orf216 C1orf94 C6orf165 CALCOCO2 CAPN1 CARD9 CCDC57 CCL7 CCNJL CCNK CIB3 CPSF7 CRACR2A CRX CTAGE5 DDX6 DGCR6 DIP2A EAF1 EIF4E2 FAM124A FAM124B FBF1 FOXP2 FRS3 FSD2 GABARAP GFAP GFI1B GOLGA2 GORASP2 GRB2 GTF2E1 HMGB1 HNF1A HNRNPF HOMEZ IKZF3 KANK2 KIFC3 KRT13 KRT15 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 L3MBTL2 LDOC1 LINC00526 LMO1 LMO2 LMO4 LSM2 MAGOHB MAPK14 MBNL1 MED31 MED4 MFAP1 MLX MORF4L2 MSX1 MTUS2 MVP MYO15B NAB2 NCDN NEK6 NOTCH2NL NUDT22 OLIG3 OSGIN1 PARVG POU2F1 PPP1R16A PRDM1 PRKAA1 PRKAA2 PRPF31 PRR3 PTRH2 QARS RBM10 RBPMS REL RELA RFX6 RHOXF2 RIMBP3 RNF31 RPL18A RUNX1 SCNM1 SDCBP SH3GL3 SIX1 SIX2 SIX3 SIX6 SKIL SMAD3 SNCAIP SNRPC SOX5 SRPK2 STK16 STX11 TBX3 TCF4 TMCC2 TRAF1 TRAF2 TRIM26 TRIM27 TRIM41 TSC22D4 TSGA10 TSSK3 U2AF2 UBXN11 VPS37B VPS37C ZBTB24 ZGPAT ZNF576	57 interactors: ABL1 ADAM19 AES ARHGAP32 ARMC7 BLOC1S6 CCDC102B CCDC36 CCDC53 CCHCR1 CDK6 CRX DTNB EFS EGLN3 EIF3H ENAH GCC1 HGS HNRNPK HOMER3 IFT20 KHDRBS1 KIAA1217 KIFC3 KRT13 KRT15 KRT19 KRT20 KRT31 KRT33B LMO2 MRFAP1L1 MRPL44 NCK2 NUP62 PCM1 PIN1 PPIF PRAM1 PRKAA1 PRKAA2 PRR16 SDCBP SH3KBP1 SNAP23 STAM2 TFIP11 TRAF3IP1 TRIM32 TRIP6 VARS2 VASP VCL VPS37C WASF2 WIPF1
Entrez ID		166	10152
HPRD ID		02556	07338
Ensembl ID		ENSG00000104964	ENSG00000138443
Uniprot IDs		Q08117 Q8WY48	E9PEZ7 Q9NYB9
PDB IDs			2ED0 3P8C
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Process Multicellular Organismal Development Cellular Metabolic Process Developmental Process Anatomical Structure Development Positive Regulation Of Cellular Biosynthetic Process Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Organ Morphogenesis Embryo Development Tissue Development RNA Processing RNA Splicing In Utero Embryonic Development Regulation Of Cell Death Organ Development	Intracellular Transport Organelle Organization Cell Projection Assembly Establishment Of Localization In Cell Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signal Transduction Response To Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Cytoskeleton Organization Negative Regulation Of Signaling Cellular Localization Cellular Component Assembly Regulation Of Signal Transduction Cell Projection Morphogenesis Cellular Response To Stimulus Developmental Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Cell Cycle Arrest Cell Projection Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Actin Cytoskeleton Organization System Development Actin Filament-based Process Anatomical Structure Development Signaling Intraciliary Transport Cell Morphogenesis Membrane Organization Generation Of Neurons Cell Communication Regulation Of Autophagy Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Protein Localization Protein Transport Neurogenesis Lamellipodium Assembly Signal Transduction Lamellipodium Organization Establishment Of Protein Localization Negative Regulation Of Cellular Senescence Microtubule-based Transport
Tagcloud ?		auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps	aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Difference) ?		auger bonefit branemark depths differently friatec germany goteborg implants imz mannheim nobelpharma osseointegrated osseointegration outermost peaks photoelectron pure shifted spectroscopy speculated spray straumann sweden switzerland tio2 titanium waldenburg xps	aba abscisic arabidopsis aux1 auxin axr4 crosstalk ein2 eir1 elongation ethylene eto1 formed2 genotyping germination insensitive insensitive2 operate overproducer1 pin pin2 positional resistant1 resistant4 responsiveness root root1 seed thaliana
Tagcloud (Intersection) ?