EXOC3 and BUB3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EXOC3	BUB3
Gene Name		exocyst complex component 3	BUB3 mitotic checkpoint protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Cytosol Secretory Granule Membrane	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Cytosol
	Molecular Function	SNARE Binding Protein Binding	Protein Binding
	Biological Process	Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Exocyst Localization Membrane Organization	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Mitotic Spindle Assembly Checkpoint Attachment Of Spindle Microtubules To Kinetochore Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division Meiotic Cell Cycle Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing	Mitotic Prometaphase Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components M Phase APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic Inactivation of APC/C via direct inhibition of the APC/C complex Mitotic Spindle Checkpoint Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Resolution of Sister Chromatid Cohesion Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Cell Cycle Checkpoints Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS		Ulcerative colitis ( 21297633)
Protein-Protein Interactions		6 interactors: APP BIRC6 BUB3 EXOC2 MLH1 RALA	17 interactors: BUB1 BUB1B CPNE1 EXOC3 HDAC1 HDAC2 NKAP PARP1 PARP2 PSTPIP1 RPL37A SUGT1 THRA TOP1 UBA1 WBP4 ZNF207
Entrez ID		11336	9184
HPRD ID		09738	04761
Ensembl ID		ENSG00000180104	ENSG00000154473
Uniprot IDs		O60645 Q69YP2	O43684
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Exocytosis Cellular Localization Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Cell Division Cell Cycle MRNA 3'-end Processing Regulation Of Cell Cycle Process Secretion By Cell Organelle Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression RNA 3'-end Processing Secretion Regulation Of Proteolysis Negative Regulation Of Mitotic Recombination Synaptic Growth At Neuromuscular Junction Microtubule-based Process Negative Regulation Of Catalytic Activity Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Recombination Membrane Raft Localization Male Meiosis Chromosome Segregation Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Meiotic Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Segregation Regulation Of Cell Cycle Phase Transition Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Reproduction Cell Death Death Axon Choice Point Recognition Regulation Of Cell Division Negative Regulation Of Endopeptidase Activity Cytoskeleton Organization Negative Regulation Of Peptidase Activity Spindle Midzone Assembly Neuron Remodeling Mitotic Nuclear Division	Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fungiform Papilla Formation Negative Regulation Of Cell Cycle Negative Regulation Of Proteasomal Protein Catabolic Process Fungiform Papilla Morphogenesis Negative Regulation Of Cellular Protein Catabolic Process Circadian Regulation Of Gene Expression Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Fungiform Papilla Development Eyelid Development In Camera-type Eye Negative Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Hair Follicle Placode Formation Tongue Morphogenesis Mitotic Nuclear Division Regulation Of Receptor Biosynthetic Process Negative Regulation Of Protein Catabolic Process Histone H4 Deacetylation Regulation Of Mitotic Nuclear Division Organelle Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein ADP-ribosylation Mitotic Cell Cycle Checkpoint Cell Division Histone H3 Deacetylation Circadian Rhythm Transcription Initiation From RNA Polymerase II Promoter Tongue Development Chromatin Remodeling Histone H3-K9 Modification Regulation Of Proteasomal Protein Catabolic Process Intracellular Receptor Signaling Pathway Regulation Of Cell Cycle Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle
Tagcloud ?		bioactive chemoattractive chemokine chemotactic constitutively cxcl16 dc dendritic dithiocarbamate functionally healing lipopolysaccharide lysoptdoh macrophages mediator modc monocyte organs pertussis pyrrolidine reflected rho secrete separately toxin trafficking transmembrane twofold wound	abrogates anaphase apc assembles attached bubr1 cdc20 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Difference) ?		bioactive chemoattractive chemokine chemotactic constitutively cxcl16 dc dendritic dithiocarbamate functionally healing lipopolysaccharide lysoptdoh macrophages mediator modc monocyte organs pertussis pyrrolidine reflected rho secrete separately toxin trafficking transmembrane twofold wound	abrogates anaphase apc assembles attached bubr1 cdc20 centrally checkpoint comet correctly cyclosome delays disassemble disassembled disassembly hela hydrolysis inactivated mad2 mcc mitotic p31 participates spindle subcomplex sufficiently trip13 turned
Tagcloud (Intersection) ?