EXOC3 and BIRC6

Number of citations of the paper that reports this interaction (PMID 18329369)
45

Data Source:
HPRD (in vivo)

		EXOC3	BIRC6
Gene Name		exocyst complex component 3	baculoviral IAP repeat containing 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Cytosol Secretory Granule Membrane	Spindle Pole Endosome Trans-Golgi Network Microtubule Organizing Center Membrane Midbody
	Molecular Function	SNARE Binding Protein Binding	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Ligase Activity
	Biological Process	Exocytosis Organelle Organization Protein Transport Cellular Protein Metabolic Process Exocyst Localization Membrane Organization	Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Spongiotrophoblast Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs
Diseases
GWAS		Ulcerative colitis ( 21297633)
Protein-Protein Interactions		6 interactors: APP BIRC6 BUB3 EXOC2 MLH1 RALA	19 interactors: BIRC5 CASP3 CASP7 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 HTRA2 MAP2K1 PLK1 RAB8A RNF41 UBC UBE2D1 USP8 VAV2
Entrez ID		11336	57448
HPRD ID		09738	05731
Ensembl ID		ENSG00000180104	ENSG00000115760
Uniprot IDs		O60645 Q69YP2	Q9NR09
PDB IDs			3CEG
Enriched GO Terms of Interacting Partners?		Cell Cycle Process Exocytosis Cellular Localization Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Cell Division Cell Cycle MRNA 3'-end Processing Regulation Of Cell Cycle Process Secretion By Cell Organelle Organization Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression RNA 3'-end Processing Secretion Regulation Of Proteolysis Negative Regulation Of Mitotic Recombination Synaptic Growth At Neuromuscular Junction Microtubule-based Process Negative Regulation Of Catalytic Activity Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Mitotic Recombination Membrane Raft Localization Male Meiosis Chromosome Segregation Negative Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Meiotic Cell Cycle Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Segregation Regulation Of Cell Cycle Phase Transition Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Reproduction Cell Death Death Axon Choice Point Recognition Regulation Of Cell Division Negative Regulation Of Endopeptidase Activity Cytoskeleton Organization Negative Regulation Of Peptidase Activity Spindle Midzone Assembly Neuron Remodeling Mitotic Nuclear Division	Regulation Of Proteolysis Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cell Death Apoptotic Signaling Pathway Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Mitotic Cell Cycle Process Positive Regulation Of Peptidase Activity Negative Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Mitotic Cell Cycle Proteolysis Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Cellular Macromolecule Catabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Protein Catabolic Process Zymogen Activation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		bioactive chemoattractive chemokine chemotactic constitutively cxcl16 dc dendritic dithiocarbamate functionally healing lipopolysaccharide lysoptdoh macrophages mediator modc monocyte organs pertussis pyrrolidine reflected rho secrete separately toxin trafficking transmembrane twofold wound	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
Tagcloud (Difference) ?		bioactive chemoattractive chemokine chemotactic constitutively cxcl16 dc dendritic dithiocarbamate functionally healing lipopolysaccharide lysoptdoh macrophages mediator modc monocyte organs pertussis pyrrolidine reflected rho secrete separately toxin trafficking transmembrane twofold wound	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
Tagcloud (Intersection) ?