EXOC3 and EXOC2

Number of citations of the paper that reports this interaction (PubMedID 14525976)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		EXOC3	EXOC2
Description		exocyst complex component 3	exocyst complex component 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Golgi Apparatus Cytosol Membrane Growth Cone Midbody Secretory Granule Membrane Cell Projection Neuron Projection Perinuclear Region Of Cytoplasm	Exocyst Cytosol Plasma Membrane Membrane Flemming Body
	Molecular Function	SNARE Binding Protein Binding Cadherin Binding	Protein Binding Protein Kinase Binding Small GTPase Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Vesicle Docking Involved In Exocytosis Protein Transport Exocyst Localization Membrane Fission Vesicle Tethering Involved In Exocytosis	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Protein Transport Membrane Fission Vesicle Tethering Involved In Exocytosis Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hypospadias ( 25108383) Red blood cell count ( 32888494) Ulcerative colitis ( 21297633)	Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 21700618 27539887 33549134) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs. brown/black hair color ( 30531825) Blood metabolite levels ( 31502714) Brown vs. black hair color ( 30531825) Dental caries ( 23064961) Diffuse large B cell lymphoma ( 25261932) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 33627673 29891935) Haemorrhoidal disease ( 33888516) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998 29785010 31959993 30054594) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer in ever smokers ( 28604730) Male-pattern baldness ( 28196072) Medication use (antiglaucoma preparations and miotics) ( 31015401) Melanoma ( 28212542) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Non-melanoma skin cancer ( 23548203) Optic cup area ( 31798171) Primary central nervous system lymphoma ( 31102405) Psoriasis ( 23143594 25574825 25903422) Schizophrenia ( 22885689) Sum eosinophil basophil counts ( 27863252) Tanning ( 19340012) Vertical cup-disc ratio ( 31798171 25241763) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waldenström macroglobulinemia / lymphoplasmacytic lymphoma ( 30305637)
Interacting Genes		11 interacting genes: APP BIRC6 BUB3 EXOC2 FSD2 GMCL1 MAILR MLH1 PPP1R12C RALA VAMP2	9 interacting genes: CDKN2A ESX1 EXOC3 EXOC7 EXOC8 RALA RANBP9 SERGEF VPS53
Entrez ID		11336	55770
HPRD ID		09738	11544
Ensembl ID		ENSG00000180104	ENSG00000112685
Uniprot IDs		O60645	Q96KP1
PDB IDs
Enriched GO Terms of Interacting Partners?		Flemming Body Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Cellular Localization Lipoprotein Particle Peptidase Inhibitor Activity Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process Low-density Lipoprotein Particle Mediated Signaling Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Secretion By Cell Edg-2 Lysophosphatidic Acid Receptor Binding Exocytosis Clathrin-sculpted Glutamate Transport Vesicle Membrane Post-Golgi Vesicle-mediated Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex	Vesicle Tethering Involved In Exocytosis Exocyst Vesicle Tethering Vesicle Docking Involved In Exocytosis Membrane Fission Exocytosis Vesicle Docking Mitotic Cytokinesis Organelle Localization By Membrane Tethering Cytoskeleton-dependent Cytokinesis Membrane Docking Secretion By Cell Secretion Flemming Body Vesicle-mediated Transport Establishment Of Protein Localization Ligase Inhibitor Activity Ras Protein Signal Transduction Intracellular Protein Localization Edg-2 Lysophosphatidic Acid Receptor Binding Positive Regulation Of Macrophage Apoptotic Process Apoptotic Process Involved In Mammary Gland Involution Exocyst Localization Organelle Localization Protein Transport Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Senescence-associated Heterochromatin Focus Localization Within Membrane Vesicle-mediated Transport To The Plasma Membrane Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Immature T Cell Proliferation In Thymus Growth Cone GARP Complex EARP Complex Negative Regulation Of Immature T Cell Proliferation Mitochondrial Depolarization Oncogene-induced Cell Senescence Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Entry Of Bacterium Into Host Cell Positive Regulation Of Mitotic Cytokinetic Process Membrane Organization Positive Regulation Of Apoptotic Process Involved In Development Membrane Raft Localization Midbody Growth Cone Membrane Vesicle-mediated Cholesterol Transport Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Myeloid Cell Apoptotic Process
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