EXOC3 and GMCL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EXOC3	GMCL1
Description		exocyst complex component 3	germ cell-less 1, spermatogenesis associated
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Golgi Apparatus Cytosol Membrane Growth Cone Midbody Secretory Granule Membrane Cell Projection Neuron Projection Perinuclear Region Of Cytoplasm	Nucleus Nuclear Matrix
	Molecular Function	SNARE Binding Protein Binding Cadherin Binding	Protein Binding Identical Protein Binding
	Biological Process	Mitotic Cytokinesis Exocytosis Vesicle Docking Involved In Exocytosis Protein Transport Exocyst Localization Membrane Fission Vesicle Tethering Involved In Exocytosis	Germ Cell Development Spermatogenesis Cell Differentiation
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hypospadias ( 25108383) Red blood cell count ( 32888494) Ulcerative colitis ( 21297633)	Atrial fibrillation ( 28416818 29892015 30061737) Colorectal or endometrial cancer ( 26621817) Red cell distribution width ( 32888494) Whole brain grey matter density ( 31530798)
Interacting Genes		11 interacting genes: APP BIRC6 BUB3 EXOC2 FSD2 GMCL1 MAILR MLH1 PPP1R12C RALA VAMP2	98 interacting genes: APLF APOL6 AXIN1 BEGAIN BSCL2 BYSL CCDC13 CCDC25 CDC37 CFAP298 CFAP410 CHIC2 CIB3 CLK2 CUL3 EHHADH ELOA EMD EXOC3 FAM50B FKBP1B FLYWCH1 FOSL2 FOXR1 FRMD6 GAGE1 GAGE10 GAGE12B GAGE12G GAGE12I GAGE12J GAGE2A GAGE2C GAGE2E GAGE5 GLRX3 GOLGA2 GRAMD1A HYKK IL17F KANK2 KAT5 KIFC3 KLHL20 KPNA2 KRT75 LNX1 MID1 MID2 MINDY1 MORF4L1 MPPE1 MTRR MYLIP MYO5B NEBL NFIL3 NTAQ1 NUMA1 PARD6B PARP16 PAX4 PBXIP1 PIBF1 PIH1D2 PPP1R18 PTPN7 QRICH1 RAD54B RANBP3 RASA1 RNF4 RNMT SHQ1 SLC15A3 SNX20 SPATA31J1 STK3 SUMO1 SUMO1P1 SYT17 SYT6 TBC1D1 TLK2 TMPO TRIM13 TRIM21 TRIM38 TRIM54 TSG101 TSSC4 UBE2I XAGE2 YY1 ZBTB24 ZMYM2 ZNF23 ZNF250
Entrez ID		11336	64395
HPRD ID		09738	13587
Ensembl ID		ENSG00000180104	ENSG00000087338
Uniprot IDs		O60645	Q53SE7 Q96IK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Flemming Body Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Synaptic Membrane Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Cellular Localization Lipoprotein Particle Peptidase Inhibitor Activity Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Immune Effector Process Low-density Lipoprotein Particle Mediated Signaling Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Guanine/thymine Mispair Binding Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Mitotic Recombination Secretion By Cell Edg-2 Lysophosphatidic Acid Receptor Binding Exocytosis Clathrin-sculpted Glutamate Transport Vesicle Membrane Post-Golgi Vesicle-mediated Transport Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex	Protein Binding Positive Regulation Of Viral Life Cycle Ubiquitin Protein Ligase Activity PML Body Protein Modification Process Regulation Of Viral Process Protein Localization To Cytoskeleton Protein Modification By Small Protein Conjugation Suppression Of Viral Release By Host Regulation Of Viral Transcription Negative Regulation Of Viral Transcription Transcription Factor Binding Protein Sumoylation Cytoplasm Post-translational Protein Modification Small Protein Activating Enzyme Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Process Modification-dependent Protein Catabolic Process
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