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SMAD4 and PRPF40A
Number of citations of the paper that reports this interaction (PubMedID
15231748
)
54
Data Source:
HPRD
(two hybrid)
SMAD4
PRPF40A
Description
SMAD family member 4
pre-mRNA processing factor 40A
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
Ciliary Basal Body
SMAD Protein Complex
Heteromeric SMAD Protein Complex
RNA Polymerase II Transcription Regulator Complex
Nucleus
Nucleoplasm
U1 SnRNP
Membrane
Nuclear Matrix
Nuclear Speck
U2-type Prespliceosome
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Collagen Binding
Filamin Binding
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
SMAD Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
I-SMAD Binding
R-SMAD Binding
RNA Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Osteoblast Differentiation
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Kidney Development
Epithelial To Mesenchymal Transition
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Cardiac Septum Development
Brainstem Development
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Single Fertilization
Gastrulation
Axon Guidance
Endoderm Development
Mesoderm Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Female Gonad Development
Anatomical Structure Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Epithelial Cell Migration
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Neural Crest Cell Differentiation
Cardiac Muscle Hypertrophy In Response To Stress
Cell Differentiation
Negative Regulation Of Cell Growth
Adrenal Gland Development
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Activin Receptor Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Catabolic Process
Embryonic Digit Morphogenesis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Neuron Fate Specification
Tissue Morphogenesis
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Cardiac Myofibril Assembly
MRNA Splicing, Via Spliceosome
MRNA Processing
Cytoskeleton Organization
Regulation Of Cell Shape
RNA Splicing
Cell Migration
Regulation Of Cytokinesis
MRNA Cis Splicing, Via Spliceosome
Cell Division
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Cardiogenesis
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Germ layer formation at gastrulation
Formation of definitive endoderm
Formation of definitive endoderm
TGFBR3 expression
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
mRNA Splicing - Major Pathway
Drugs
Diseases
Colorectal cancer
Juvenile polyposis syndrome
Hereditary hemorrhagic telangiectasia (HHT)
Pancreatic cancer
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Heel bone mineral density (
30598549
)
Memory dysfunction in frontotemporal lobe dementia (
29724592
)
Metabolite levels (
23823483
)
Pulse pressure (
30224653
)
Refractive error (
32231278
)
Interacting Genes
212 interacting genes:
ACVR1B
AKT1
ALDOB
AOPEP
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BAAT
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CCDC180
CD59
CDC14B
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
ETV4
EWSR1
FANCC
FBLN1
FBP2
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HEMGN
HMG20A
HNF4A
HOXA9
HOXC8
HRAS
HYAL2
IL24
ITK
JUN
JUNB
JUND
LAMTOR5
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MSANTD3
MYOD1
NAT8
NEK6
NELFCD
NFKBID
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PPP2CB
PPP3R2
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SFRP2
SFRP4
SHC1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
STX17
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TLE5
TM9SF2
TOB1
TRAP1
TRIP12
TSSK3
TSTD2
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP10
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZIC1
ZMYM2
ZNF189
ZNF423
ZNF510
ZNF521
ZNF8
132 interacting genes:
ABI1
AKAP8L
APBB1IP
ARFGEF2
ASXL2
ATAD3A
BAG6
BEND7
BRD4
CAP2
CCNL1
CCT2
CCT4
CCT7
CDK12
CDK13
CHD3
CHERP
CPSF6
CT45A1
CUL1
CYFIP1
CYFIP2
DAAM1
DDIT4L
DHX15
DHX8
DHX9
DIAPH1
DZIP1
DZIP1L
ENAH
ERG
EVL
FASLG
FMN1
FMNL1
FMNL2
FMNL3
FN1
FNBP4
FRA10AC1
GAPDH
HIPK1
HNRNPF
HNRNPK
HNRNPU
HNRNPUL1
HSPB1
HSPG2
HTT
IL1RAP
KMT2B
LARP7
LTBP3
MAP1LC3A
MECP2
MMP11
NCKAP1L
NKAP
NKAPD1
NONO
PCBP2
PDCD7
PECAM1
PFKL
PIAS1
PIAS3
PIAS4
PICK1
PPIG
PRKAR1A
PSG5
PTBP1
PTPRF
RBM39
RBMX2
RCC2
RLF
RNF10
RPL4
RPLP0
SDCBP
SDCBP2
SDK1
SERPINB9
SF1
SF3A1
SF3A2
SF3A3
SF3B2
SF3B3
SFPQ
SMAD4
SNIP1
SNRNP70
SON
SPMIP2
SREK1
SREK1IP1
SRPK2
STIM2
TCEAL9
TMEM132D
U2AF1
U2AF2
U2SURP
UBE2I
UBE2K
UBQLN1
UBQLN2
UBQLN4
UBR4
USP7
VASP
VCL
WAS
WASF2
WASL
WBP11
WBP4
WIPF1
XRCC6
YBX1
YLPM1
YWHAG
ZCCHC10
ZCCHC8
ZFHX3
ZHX1
ZNF341
ZNF451
Entrez ID
4089
55660
HPRD ID
02995
10995
Ensembl ID
ENSG00000141646
ENSG00000196504
Uniprot IDs
A0A024R274
Q13485
A0A7N4I394
A0A8Q3SIG7
A0A8V8TM61
F5H578
O75400
PDB IDs
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
6YIC
1UZC
1YWI
1YWJ
1ZR7
2CQN
2DYF
2KZG
2L5F
2L9V
2LKS
8PXW
8PXX
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
SMAD Binding
Nucleoplasm
Intracellular Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Signal Transduction
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Ubiquitin Protein Ligase Binding
Enzyme-linked Receptor Protein Signaling Pathway
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
I-SMAD Binding
Intracellular Signaling Cassette
Cell Surface Receptor Signaling Pathway
Chromatin
Cell Differentiation
SMAD Protein Signal Transduction
RNA Splicing
MRNA Processing
MRNA Metabolic Process
RNA Processing
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Binding
Nuclear Speck
Nucleic Acid Binding
Spliceosomal Complex
Nucleoplasm
Nucleus
Spliceosomal Complex Assembly
RNA Metabolic Process
U2 SnRNP
Catalytic Step 2 Spliceosome
Nucleic Acid Metabolic Process
U2-type Prespliceosome Assembly
Actin Binding
U2-type Precatalytic Spliceosome
Profilin Binding
SCAR Complex
Cellular Component Assembly
Actin Polymerization Or Depolymerization
Regulation Of RNA Splicing
Nucleobase-containing Compound Metabolic Process
Ribonucleoprotein Complex
MRNA 3'-splice Site Recognition
Regulation Of MRNA Processing
Regulation Of MRNA Splicing, Via Spliceosome
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Protein-RNA Complex Assembly
Actin Filament-based Process
Positive Regulation Of Protein Localization To Cajal Body
Positive Regulation Of Metabolic Process
Protein Binding
Alternative MRNA Splicing, Via Spliceosome
U12-type Spliceosomal Complex
Regulation Of Macromolecule Metabolic Process
PML Body
SUMO Ligase Activity
Cytosol
U2-type Spliceosomal Complex
Positive Regulation Of Macromolecule Metabolic Process
Actin Cytoskeleton Organization
Focal Adhesion
Regulation Of Metabolic Process
U2-type Prespliceosome
CRD-mediated MRNA Stability Complex
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Tagcloud (Difference)
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Tagcloud (Intersection)
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