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SMAD4 and RIPK2
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
SMAD4
RIPK2
Description
SMAD family member 4
receptor interacting serine/threonine kinase 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
Ciliary Basal Body
SMAD Protein Complex
Heteromeric SMAD Protein Complex
RNA Polymerase II Transcription Regulator Complex
Cytoplasm
Endoplasmic Reticulum
Cytosol
Cytoskeleton
Plasma Membrane
Membrane
Vesicle
Protein-containing Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Collagen Binding
Filamin Binding
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
SMAD Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
I-SMAD Binding
R-SMAD Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
LIM Domain Binding
Signaling Adaptor Activity
Identical Protein Binding
Protein Homodimerization Activity
CARD Domain Binding
Caspase Binding
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Osteoblast Differentiation
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Kidney Development
Epithelial To Mesenchymal Transition
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Cardiac Septum Development
Brainstem Development
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Single Fertilization
Gastrulation
Axon Guidance
Endoderm Development
Mesoderm Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Female Gonad Development
Anatomical Structure Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Epithelial Cell Migration
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Neural Crest Cell Differentiation
Cardiac Muscle Hypertrophy In Response To Stress
Cell Differentiation
Negative Regulation Of Cell Growth
Adrenal Gland Development
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Activin Receptor Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Catabolic Process
Embryonic Digit Morphogenesis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Neuron Fate Specification
Tissue Morphogenesis
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Cytokine Production
Positive Regulation Of Cytokine-mediated Signaling Pathway
Adaptive Immune Response
Immune System Process
Positive Regulation Of T-helper 1 Type Immune Response
Apoptotic Process
Inflammatory Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Cytokine-mediated Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Immature T Cell Proliferation In Thymus
Positive Regulation Of Immature T Cell Proliferation In Thymus
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
CD4-positive, Alpha-beta T Cell Proliferation
P38MAPK Cascade
T Cell Proliferation
Defense Response To Bacterium
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of T-helper 1 Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-positive Bacterium
T Cell Receptor Signaling Pathway
Protein Homooligomerization
Stress-activated MAPK Cascade
Positive Regulation Of Macrophage Cytokine Production
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Response To Interleukin-1
Response To Interleukin-12
Response To Interleukin-18
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Regulation Of Primary Metabolic Process
Protein Linear Polyubiquitination
Xenophagy
Cell Surface Toll-like Receptor Signaling Pathway
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Xenophagy
Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Cardiogenesis
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Germ layer formation at gastrulation
Formation of definitive endoderm
Formation of definitive endoderm
TGFBR3 expression
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
Downstream TCR signaling
p75NTR recruits signalling complexes
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Fostamatinib
Diseases
Colorectal cancer
Juvenile polyposis syndrome
Hereditary hemorrhagic telangiectasia (HHT)
Pancreatic cancer
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Cerebral amyloid deposition (PET imaging) (
26252872
)
Cognitive performance (
20125193
)
Crohn's disease (
23128233
)
Leprosy (
20018961
25642632
27976721
)
Interacting Genes
212 interacting genes:
ACVR1B
AKT1
ALDOB
AOPEP
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BAAT
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CCDC180
CD59
CDC14B
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
ETV4
EWSR1
FANCC
FBLN1
FBP2
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HEMGN
HMG20A
HNF4A
HOXA9
HOXC8
HRAS
HYAL2
IL24
ITK
JUN
JUNB
JUND
LAMTOR5
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MSANTD3
MYOD1
NAT8
NEK6
NELFCD
NFKBID
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PPP2CB
PPP3R2
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SFRP2
SFRP4
SHC1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
STX17
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TLE5
TM9SF2
TOB1
TRAP1
TRIP12
TSSK3
TSTD2
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP10
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZIC1
ZMYM2
ZNF189
ZNF423
ZNF510
ZNF521
ZNF8
38 interacting genes:
ATG16L1
BCL10
BECN1
BIRC2
CARD16
CARD6
CASP1
CASP8
CD40
CFLAR
CHUK
IKBKG
IRAK1
KDM3A
LRRK2
MAVS
NGFR
NOD1
NOD2
PELI3
PRMT2
SMAD4
SMURF1
TLR2
TLR4
TNFRSF1A
TRAF1
TRAF2
TRAF5
TRAF6
UBC
UBE2I
ULK1
YWHAB
YWHAE
YWHAG
YWHAQ
ZNRF4
Entrez ID
4089
8767
HPRD ID
02995
04585
Ensembl ID
ENSG00000141646
ENSG00000104312
Uniprot IDs
A0A024R274
Q13485
A0A0S2Z4Z8
O43353
PDB IDs
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
6YIC
2N7Z
2N83
4C8B
5AR2
5AR3
5AR4
5AR5
5AR7
5AR8
5J79
5J7B
5NG0
5NG2
5NG3
5W5J
5W5O
5YRN
6ES0
6FU5
6GFJ
6GGS
6HMX
6RN8
6RNA
6S1F
6SZE
6SZJ
6UL8
7OBS
7OBT
8AZA
8X2O
9F3V
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
SMAD Binding
Nucleoplasm
Intracellular Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Signal Transduction
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Ubiquitin Protein Ligase Binding
Enzyme-linked Receptor Protein Signaling Pathway
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
I-SMAD Binding
Intracellular Signaling Cassette
Cell Surface Receptor Signaling Pathway
Chromatin
Cell Differentiation
SMAD Protein Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signaling Pathway
Activation Of Innate Immune Response
Regulation Of Apoptotic Process
Positive Regulation Of Defense Response
Regulation Of Programmed Cell Death
Identical Protein Binding
Immune Response-regulating Signaling Pathway
Regulation Of Innate Immune Response
Positive Regulation Of Immune Response
Immune Response-activating Signaling Pathway
Regulation Of Immune Response
Regulation Of Defense Response
Signal Transduction
CD40 Receptor Complex
Intracellular Signaling Cassette
Positive Regulation Of Innate Immune Response
Positive Regulation Of Immune System Process
Intracellular Signal Transduction
Activation Of Immune Response
Protein-containing Complex Binding
Response To External Biotic Stimulus
CARD Domain Binding
Cellular Response To Oxygen-containing Compound
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Cytokine Production
Response To Other Organism
Regulation Of Cytokine Production
Regulation Of Cytokine-mediated Signaling Pathway
Signaling Adaptor Activity
Cell Surface Receptor Signaling Pathway
Defense Response
Regulation Of Immune System Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Response To Stress
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Tagcloud (Intersection)
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