PRPF40A and CDK12

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		PRPF40A	CDK12
Gene Name		PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	cyclin-dependent kinase 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Nuclear Matrix Nuclear Speck	Cyclin K-CDK12 Complex Nucleus Nucleoplasm Nucleolus Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex
	Molecular Function	Protein Binding Poly(A) RNA Binding Proline-rich Region Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity Cyclin Binding
	Biological Process	MRNA Processing Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis Cell Division	MRNA Processing RNA Splicing Regulation Of MAP Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		120 interactors: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BRD4 CAP2 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CSNK2A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDX46 DHX15 DHX8 DHX9 DIAPH1 ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SRPK2 STIM2 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WBP5 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	7 interactors: EWSR1 MBP PIN1 POLR2A PRPF40A SRSF1 SRSF2
Entrez ID		55660	51755
HPRD ID		10995	10849
Ensembl ID		ENSG00000196504	ENSG00000167258
Uniprot IDs		O75400 Q05C41	Q9NYV4
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Process Cellular Metabolic Process Cellular Component Assembly Actin Cytoskeleton Organization MRNA 3'-splice Site Recognition Actin Polymerization Or Depolymerization Actin Filament-based Process Cytoskeleton Organization RNA Biosynthetic Process Regulation Of Organelle Organization Transcription, DNA-templated Organelle Organization Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Component Organization CRD-mediated MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Protein Sumoylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of RNA Splicing Cell Differentiation Negative Regulation Of Cellular Metabolic Process Actin Filament Organization Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Multicellular Organismal Development Spliceosomal Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of RNA Metabolic Process Developmental Process	RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Termination Of RNA Polymerase II Transcription Regulation Of Cytokinesis MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus MRNA 3'-end Processing Regulation Of RNA Splicing RNA 3'-end Processing Nuclear Export MRNA Transport Transcription, RNA-templated RNA Transport RNA Metabolic Process RNA Localization Defense Response To Nematode Gene Expression MRNA 5'-splice Site Recognition Transcription From RNA Polymerase II Promoter Negative Regulation Of Cytokine Production Response To Nematode Regulation Of Cell Division Transcription, DNA-templated Nucleocytoplasmic Transport Nuclear Transport RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Interleukin-10 Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Cis Splicing, Via Spliceosome Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Interleukin-4 Production Response To Mercury Ion Regulation Of Cell Morphogenesis Regulation Of Cellular Process Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process 7-methylguanosine MRNA Capping Regulation Of Interleukin-4 Production PiRNA Metabolic Process Regulation Of Cytokine Production Positive Regulation Of RNA Splicing 7-methylguanosine RNA Capping Substantia Nigra Development
Tagcloud ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic	affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Difference) ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 transcriptome verifying xenobiotic	affects associate bulk ccnk cdk13 cdk9 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec snorna super tagged tefb
Tagcloud (Intersection) ?		seq