PRPF40A and CCT4

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		PRPF40A	CCT4
Gene Name		PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	chaperonin containing TCP1, subunit 4 (delta)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Nuclear Matrix Nuclear Speck	Zona Pellucida Receptor Complex Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Poly(A) RNA Binding Proline-rich Region Binding	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	MRNA Processing Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis Cell Division	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport
Pathways			Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS
Protein-Protein Interactions		120 interactors: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BRD4 CAP2 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CSNK2A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDX46 DHX15 DHX8 DHX9 DIAPH1 ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SRPK2 STIM2 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WBP5 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	10 interactors: ACTA1 ACTA2 ACTB CCNE1 CFAP52 PRPF40A RFWD2 RPS6KA1 UBC VRK2
Entrez ID		55660	10575
HPRD ID		10995	05506
Ensembl ID		ENSG00000196504	ENSG00000115484
Uniprot IDs		O75400 Q05C41	B7Z2F4 P50991
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Process Cellular Metabolic Process Cellular Component Assembly Actin Cytoskeleton Organization MRNA 3'-splice Site Recognition Actin Polymerization Or Depolymerization Actin Filament-based Process Cytoskeleton Organization RNA Biosynthetic Process Regulation Of Organelle Organization Transcription, DNA-templated Organelle Organization Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Component Organization CRD-mediated MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Protein Sumoylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of RNA Splicing Cell Differentiation Negative Regulation Of Cellular Metabolic Process Actin Filament Organization Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Multicellular Organismal Development Spliceosomal Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of RNA Metabolic Process Developmental Process	Cell Cycle Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Toll-like Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Positive Regulation Of Hepatic Stellate Cell Activation Signal Transduction By P53 Class Mediator Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Innate Immune Response-activating Signal Transduction Regulation Of Cell Cycle G1/S Phase Transition Response To Stimulus Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Immune Response Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Movement Of Cell Or Subcellular Component G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic	20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Difference) ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic	20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Intersection) ?