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SMAD4 and CHEK1
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
SMAD4
CHEK1
Description
SMAD family member 4
checkpoint kinase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
Ciliary Basal Body
SMAD Protein Complex
Heteromeric SMAD Protein Complex
RNA Polymerase II Transcription Regulator Complex
Chromosome, Telomeric Region
Chromatin
Condensed Nuclear Chromosome
Extracellular Space
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Protein-containing Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Collagen Binding
Filamin Binding
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
SMAD Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
I-SMAD Binding
R-SMAD Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Domain Specific Binding
Histone H3T11 Kinase Activity
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Osteoblast Differentiation
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Kidney Development
Epithelial To Mesenchymal Transition
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Cardiac Septum Development
Brainstem Development
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Single Fertilization
Gastrulation
Axon Guidance
Endoderm Development
Mesoderm Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Female Gonad Development
Anatomical Structure Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Epithelial Cell Migration
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Neural Crest Cell Differentiation
Cardiac Muscle Hypertrophy In Response To Stress
Cell Differentiation
Negative Regulation Of Cell Growth
Adrenal Gland Development
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Activin Receptor Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Catabolic Process
Embryonic Digit Morphogenesis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Neuron Fate Specification
Tissue Morphogenesis
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Cardiac Myofibril Assembly
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Inner Cell Mass Cell Proliferation
DNA Replication
DNA Repair
Chromatin Remodeling
Protein Phosphorylation
Apoptotic Process
DNA Damage Response
Nucleus Organization
Nuclear Envelope Organization
Mitotic Nuclear Membrane Disassembly
Mitotic G2 DNA Damage Checkpoint Signaling
Regulation Of Gene Expression
Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Peptidyl-threonine Phosphorylation
Regulation Of Cell Population Proliferation
Signal Transduction In Response To DNA Damage
Mitotic G2/M Transition Checkpoint
Positive Regulation Of Cell Cycle
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Mitotic Nuclear Division
Regulation Of Mitotic Centrosome Separation
Negative Regulation Of G0 To G1 Transition
Cellular Response To Mechanical Stimulus
Replicative Senescence
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Cell Cycle Phase Transition
Apoptotic Process Involved In Development
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Cardiogenesis
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Germ layer formation at gastrulation
Formation of definitive endoderm
Formation of definitive endoderm
TGFBR3 expression
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Signaling by SCF-KIT
Activation of ATR in response to replication stress
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Transcriptional Regulation by E2F6
Drugs
XL844
Enzastaurin
CHIR-124
N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE
3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE
2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
(2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
2-(cyclohexylamino)benzoic acid
3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
(3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
(5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
(3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
(2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
(2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
(5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE
5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
[4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol
6-MORPHOLIN-4-YL-9H-PURINE
1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE
Prexasertib
Fostamatinib
LY-2608204
PF-477736
Diseases
Colorectal cancer
Juvenile polyposis syndrome
Hereditary hemorrhagic telangiectasia (HHT)
Pancreatic cancer
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Breast cancer (survival) (
25890600
)
Squamous cell lung carcinoma (
28604730
)
Interacting Genes
212 interacting genes:
ACVR1B
AKT1
ALDOB
AOPEP
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BAAT
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CCDC180
CD59
CDC14B
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
ETV4
EWSR1
FANCC
FBLN1
FBP2
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HEMGN
HMG20A
HNF4A
HOXA9
HOXC8
HRAS
HYAL2
IL24
ITK
JUN
JUNB
JUND
LAMTOR5
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MSANTD3
MYOD1
NAT8
NEK6
NELFCD
NFKBID
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PPP2CB
PPP3R2
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SFRP2
SFRP4
SHC1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
STX17
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TLE5
TM9SF2
TOB1
TRAP1
TRIP12
TSSK3
TSTD2
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP10
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZIC1
ZMYM2
ZNF189
ZNF423
ZNF510
ZNF521
ZNF8
61 interacting genes:
AATF
AKT1
APP
ATM
ATR
ATXN3
BAD
BCL2L1
BLM
BRCA1
BRCA2
CDC14B
CDC25A
CDC25B
CDC25C
CDH1
CEBPA
CHUK
CLSPN
CNTN2
CSNK2B
CUL1
CUL4A
DBF4
DTL
FANCE
HSP90AA1
ILKAP
LATS2
MAPT
MCM6
MCM7
MCPH1
MDM4
MED1
NPM1
PIGM
PPP1R12A
PRKAA1
PRKDC
RAD23A
RAD51
RB1
RELA
SMAD4
TIMELESS
TLK1
TOPBP1
TP53
TP53BP1
TRAF4
UBA1
UBA2
UBB
UBC
UBE2T
USP3
XIAP
XPO1
XRCC6
YWHAG
Entrez ID
4089
1111
HPRD ID
02995
04356
Ensembl ID
ENSG00000141646
ENSG00000149554
Uniprot IDs
A0A024R274
Q13485
B4DT73
E7EPP6
O14757
PDB IDs
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
6YIC
1IA8
1NVQ
1NVR
1NVS
1ZLT
1ZYS
2AYP
2BR1
2BRB
2BRG
2BRH
2BRM
2BRN
2BRO
2C3J
2C3K
2C3L
2CGU
2CGV
2CGW
2CGX
2E9N
2E9O
2E9P
2E9U
2E9V
2GDO
2GHG
2HOG
2HXL
2HXQ
2HY0
2QHM
2QHN
2R0U
2WMQ
2WMR
2WMS
2WMT
2WMU
2WMV
2WMW
2WMX
2X8D
2X8E
2X8I
2XEY
2XEZ
2XF0
2YDI
2YDJ
2YDK
2YER
2YEX
2YM3
2YM4
2YM5
2YM6
2YM7
2YM8
2YWP
3F9N
3JVR
3JVS
3NLB
3OT3
3OT8
3PA3
3PA4
3PA5
3TKH
3TKI
3U9N
4FSM
4FSN
4FSQ
4FSR
4FST
4FSU
4FSW
4FSY
4FSZ
4FT0
4FT3
4FT5
4FT7
4FT9
4FTA
4FTC
4FTI
4FTJ
4FTK
4FTL
4FTM
4FTN
4FTO
4FTQ
4FTR
4FTT
4FTU
4GH2
4HYH
4HYI
4JIK
4QYE
4QYF
4QYG
4QYH
4RVK
4RVL
4RVM
5DLS
5F4N
5OOP
5OOR
5OOT
5OP2
5OP4
5OP5
5OP7
5OPB
5OPR
5OPS
5OPU
5OPV
5OQ5
5OQ6
5OQ7
5OQ8
5WI2
6FC8
6FCF
6FCK
7AKM
7AKO
7BJD
7BJE
7BJH
7BJJ
7BJM
7BJO
7BJR
7BJX
7BK1
7BK2
7BK3
7BKN
7BKO
7MCK
7SUF
7SUG
7SUH
7SUI
7SUJ
8E80
8E81
8SIV
8SIW
8SIX
9CE4
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
SMAD Binding
Nucleoplasm
Intracellular Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Signal Transduction
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Ubiquitin Protein Ligase Binding
Enzyme-linked Receptor Protein Signaling Pathway
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
I-SMAD Binding
Intracellular Signaling Cassette
Cell Surface Receptor Signaling Pathway
Chromatin
Cell Differentiation
SMAD Protein Signal Transduction
DNA Damage Response
Cellular Response To Stress
Regulation Of Cell Cycle
Nucleoplasm
DNA Repair
Regulation Of Protein Metabolic Process
DNA Metabolic Process
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Process
Response To Stress
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Nucleus
Response To Radiation
Intracellular Signal Transduction
Regulation Of Cell Cycle G2/M Phase Transition
Nucleic Acid Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Response To Ionizing Radiation
Signal Transduction In Response To DNA Damage
Nucleobase-containing Compound Metabolic Process
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Protein Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Protein Modification Process
DNA Damage Checkpoint Signaling
Negative Regulation Of Cell Cycle
Cellular Response To Ionizing Radiation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
Cellular Response To Radiation
Regulation Of DNA Metabolic Process
Double-strand Break Repair
Negative Regulation Of Cell Cycle Phase Transition
Response To Xenobiotic Stimulus
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Protein Catabolic Process
Mitotic DNA Integrity Checkpoint Signaling
Response To X-ray
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cell Cycle
Mitotic G2/M Transition Checkpoint
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Identical Protein Binding
Protein Modification Process
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Tagcloud (Intersection)
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