PRPF40A and LTBP3

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPF40A	LTBP3
Description		pre-mRNA processing factor 40A	latent transforming growth factor beta binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Extracellular Region Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	Calcium Ion Binding Protein Binding Growth Factor Binding Transforming Growth Factor Beta Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division	Skeletal System Development Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Bone Resorption Bone Remodeling Bone Morphogenesis Lung Saccule Development Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		mRNA Splicing - Major Pathway	Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs
Drugs
Diseases			Tooth agenesis; Hypodontia
GWAS		Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)	Acne (severe) ( 24927181) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Osteoarthritis (hip) ( 30374069) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 23263486) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	17 interacting genes: CACNA1A CCNG1 DYRK1A GORASP2 HBEGF HOXA1 ITGB5 MBD1 NUFIP2 PELI2 PIK3R2 PRPF40A RAC1 SHANK3 TGFB1 TGFB2 TGFB3
Entrez ID		55660	4054
HPRD ID		10995	03649
Ensembl ID		ENSG00000196504	ENSG00000168056
Uniprot IDs		A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400	B9EG76 Q8WYU6 Q9NS15
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex	Type III Transforming Growth Factor Beta Receptor Binding Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Type II Transforming Growth Factor Beta Receptor Binding Salivary Gland Morphogenesis Negative Regulation Of Macrophage Cytokine Production Regulation Of Cytoskeleton Organization Transforming Growth Factor Beta Receptor Binding Regulation Of Actin Cytoskeleton Organization Uterine Wall Breakdown Regulation Of Actin Filament-based Process Enzyme-linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Gland Morphogenesis Positive Regulation Of Protein Transport Face Morphogenesis Response To Progesterone Negative Regulation Of Cytokine Production Involved In Immune Response Regulation Of Macrophage Cytokine Production Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Secretion Growth Factor Activity Inner Ear Development Regulation Of Cell Division Cell-cell Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Supramolecular Fiber Organization Positive Regulation Of Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Platelet Alpha Granule Lumen Regulation Of Interleukin-23 Production Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Protein Transport Type I Transforming Growth Factor Beta Receptor Binding Positive Regulation Of Protein Localization Cell Junction Organization Secondary Palate Development Regulation Of Organelle Organization Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Cell Division Positive Regulation Of Cardiocyte Differentiation Regulation Of Stress Fiber Assembly Regulation Of Actin Filament Organization Regulation Of Protein Secretion Positive Regulation Of Protein Localization To Nucleus Odontogenesis Regulation Of Establishment Of Protein Localization Cell Migration Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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