PRPF40A and PFKL

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPF40A	PFKL
Description		pre-mRNA processing factor 40A	phosphofructokinase, liver type
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Extracellular Region Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Monosaccharide Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division	Fructose 6-phosphate Metabolic Process Glycolytic Process Response To Glucose Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Insulin Secretion Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis
Pathways		mRNA Splicing - Major Pathway	Neutrophil degranulation Glycolysis
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Rheumatoid arthritis ( 21505073)
Interacting Genes		132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	18 interacting genes: APP ATN1 CEBPA COPS6 DNAAF5 GTPBP3 KRTAP10-7 KRTAP4-12 KRTAP5-9 MYD88 PFKM PRPF40A SHANK3 SUMO2 TESK1 TNFAIP3 USP39 YWHAQ
Entrez ID		55660	5211
HPRD ID		10995	01385
Ensembl ID		ENSG00000196504	ENSG00000141959
Uniprot IDs		A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400	P17858 Q7L2M7
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX	7LW1 8W2G 8W2H 8W2I 8W2J
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex	Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Response To Calcium Ion Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Interleukin-1 Production Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Interleukin-6 Production Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response Memory Cytosol Leukocyte Activation Involved In Inflammatory Response Identical Protein Binding Regulation Of Interleukin-1 Beta Production Kinase Binding Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Intermediate Filament Regulation Of Toll-like Receptor 4 Signaling Pathway TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Phosphofructokinase Activity Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate Tolerance Induction To Lipopolysaccharide Protein Modification By Small Protein Removal Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Macrophage Differentiation Positive Regulation Of Protein Localization Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Proteolysis Positive Regulation Of Defense Response
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