PRPF40A and BRD4

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRPF40A	BRD4
Gene Name		PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	bromodomain containing 4
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Membrane Nuclear Matrix Nuclear Speck	Nuclear Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm Positive Transcription Elongation Factor Complex B
	Molecular Function	Protein Binding Poly(A) RNA Binding Proline-rich Region Binding	P53 Binding DNA Binding Chromatin Binding Protein Binding Lysine-acetylated Histone Binding
	Biological Process	MRNA Processing Cytoskeleton Organization Cell Cycle Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis Cell Division	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Inner Cell Mass Cell Proliferation Chromatin Remodeling Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus Chromosome Segregation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Histone H4-K12 Acetylation Histone H3-K14 Acetylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Inflammatory Response Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Negative Regulation Of DNA Damage Checkpoint
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		120 interactors: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BRD4 CAP2 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CSNK2A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDX46 DHX15 DHX8 DHX9 DIAPH1 ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PPIG PRKAR1A PSG5 PTPRF RBM39 RBMX2 RCC2 RLF RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SMAD4 SNIP1 SNRNP70 SON SRPK2 STIM2 U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 VASP VCL WAS WASF2 WASL WBP11 WBP4 WBP5 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	18 interactors: C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 HIST2H3C HIST2H4A HIST4H4 JMJD6 MESDC2 PRPF40A RFC1 RFC2 RFC3 RFC4 RFC5 TCERG1
Entrez ID		55660	23476
HPRD ID		10995	10574
Ensembl ID		ENSG00000196504	ENSG00000141867
Uniprot IDs		O75400 Q05C41	O60885
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS	2I8N 2LSP 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4KV1 4KV4 4LR6 4LRG 4MEN 4MEO 4MEP 4MEQ
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Process Cellular Metabolic Process Cellular Component Assembly Actin Cytoskeleton Organization MRNA 3'-splice Site Recognition Actin Polymerization Or Depolymerization Actin Filament-based Process Cytoskeleton Organization RNA Biosynthetic Process Regulation Of Organelle Organization Transcription, DNA-templated Organelle Organization Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Cellular Component Organization CRD-mediated MRNA Stabilization Regulation Of Gene Expression Positive Regulation Of Organelle Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Actin Nucleation Regulation Of Protein Metabolic Process Protein Sumoylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of RNA Splicing Cell Differentiation Negative Regulation Of Cellular Metabolic Process Actin Filament Organization Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Multicellular Organismal Development Spliceosomal Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Rhythmic Process Regulation Of RNA Metabolic Process Developmental Process	Telomere Maintenance Nucleotide-excision Repair, DNA Gap Filling Telomere Maintenance Via Semi-conservative Replication Nuclear DNA Replication Telomere Maintenance Via Recombination Mitotic Recombination DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Transcription-coupled Nucleotide-excision Repair Cell Cycle Nucleotide-excision Repair DNA-dependent DNA Replication Mitotic Cell Cycle Homeostatic Process DNA Methylation On Cytosine Chromosome Organization DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Recombination Cellular Nitrogen Compound Metabolic Process DNA Replication Nitrogen Compound Metabolic Process Chromatin Silencing Histone Demethylation Protein Demethylation Histone H4-K20 Demethylation Negative Regulation Of Megakaryocyte Differentiation Organelle Organization DNA Methylation Demethylation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly DNA Modification Cellular Metabolic Process DNA Repair Cell Cycle Process Gene Silencing Cellular Homeostasis Regulation Of Megakaryocyte Differentiation Gene Expression Cell Division CENP-A Containing Nucleosome Assembly Cellular Macromolecule Biosynthetic Process Cellular Response To DNA Damage Stimulus Macromolecule Biosynthetic Process
Tagcloud ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic	3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Difference) ?		arginine arid3b arnt2 ascribed aspartate catabolism clmn defining deregulated ectopic fads1 focusing fth1 kpna2 lphn2 missense pard6b pde4c pias2 proline pygl regardless repressor reprogramming rhobtb2 seq transcriptome verifying xenobiotic	3d chip combining compensatory confirming consequently deprived downregulate driver enrichment estrogens everolimus feedback jq1 loops lted matrigel mediating mimic mtor myc ofmycby oncogenes otherwise resensitization signatures uncover upregulation xenograft
Tagcloud (Intersection) ?