PRPF40A and DIAPH1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		PRPF40A	DIAPH1
Description		pre-mRNA processing factor 40A	diaphanous related formin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Nucleus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Actin Filament Plasma Membrane Membrane Secretory Granule Membrane Ruffle Membrane Cell Projection Mitotic Spindle Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Binding Protein Binding	RNA Binding Actin Binding Signaling Receptor Binding Protein Binding Small GTPase Binding Transmembrane Transporter Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division	Cytoskeleton Organization Sensory Perception Of Sound Regulation Of Cell Shape Actin Cytoskeleton Organization Actin Filament Polymerization Regulation Of Microtubule-based Process Protein Localization To Microtubule Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cytoskeleton Organization Cellular Response To Histamine
Pathways		mRNA Splicing - Major Pathway	RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RHOD GTPase cycle RHOF GTPase cycle Regulation of MITF-M dependent genes involved in invasion
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)	Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29083406) Femur bone mineral density x serum urate levels interaction ( 34046847) Mean platelet volume ( 27863252 32888494) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	18 interacting genes: APBB1 BAIAP2 CDC42 CDC7 CENPA EGFR GAS7 NEDD4 PAX6 PKD2 PRPF40A PTPRF RAC1 RHOA RHOC TCERG1 WBP4 XPO6
Entrez ID		55660	1729
HPRD ID		10995	03670
Ensembl ID		ENSG00000196504	ENSG00000131504
Uniprot IDs		A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400	A0A2R8Y5N1 O60610 Q6URC4
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX	8FG1
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex	Proline-rich Region Binding Cell Projection Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Stress Fiber Assembly Anatomical Structure Morphogenesis Cell Projection Organization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Skeletal Muscle Satellite Cell Migration Lamellipodium Cell Migration Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Stress Fiber Assembly Regulation Of Cell Projection Organization Cerebral Cortex Cell Migration Cell Motility Regulation Of Cell Cycle Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Actin Filament Organization Regulation Of Actin Filament Organization Neuron Projection Development Telencephalon Cell Migration Regulation Of Synapse Organization Forebrain Cell Migration Membrane Invagination Plasma Membrane Bounded Cell Projection Organization Non-canonical Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Modification Of Postsynaptic Actin Cytoskeleton G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Lipase Activity Apical Junction Assembly Regulation Of Cell Division Cell-cell Junction Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Mitotic Cytokinesis Thioesterase Binding Salivary Gland Morphogenesis Positive Regulation Of Protein-containing Complex Assembly G Protein Activity Regulation Of Cell Cycle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Neuron Projection Development Protein Kinase Binding Postsynapse Cell Junction Organization Regulation Of Cytokinesis
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