PRPF40A and RCC2

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		PRPF40A	RCC2
Description		pre-mRNA processing factor 40A	regulator of chromosome condensation 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U1 SnRNP Membrane Nuclear Matrix Nuclear Speck U2-type Prespliceosome	Chromosome, Centromeric Region Nucleus Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Membrane Midbody Early Endosome Membrane Chromosome, Centromeric Core Domain Mitotic Spindle Midzone
	Molecular Function	RNA Binding Protein Binding	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Microtubule Binding Protein Kinase Binding Protein Domain Specific Binding Small GTPase Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Cytoskeleton Organization Regulation Of Cell Shape RNA Splicing Cell Migration Regulation Of Cytokinesis MRNA Cis Splicing, Via Spliceosome Cell Division	Integrin-mediated Signaling Pathway Regulation Of Fibroblast Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Migration Negative Regulation Of GTPase Activity Establishment Of Protein Localization Focal Adhesion Assembly Cell Division Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore Chromosome Passenger Complex Localization To Kinetochore Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Ruffle Assembly
Pathways		mRNA Splicing - Major Pathway	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Metabolite levels ( 23823483) Pulse pressure ( 30224653) Refractive error ( 32231278)	Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Non-melanoma skin cancer ( 29739929)
Interacting Genes		132 interacting genes: ABI1 AKAP8L APBB1IP ARFGEF2 ASXL2 ATAD3A BAG6 BEND7 BRD4 CAP2 CCNL1 CCT2 CCT4 CCT7 CDK12 CDK13 CHD3 CHERP CPSF6 CT45A1 CUL1 CYFIP1 CYFIP2 DAAM1 DDIT4L DHX15 DHX8 DHX9 DIAPH1 DZIP1 DZIP1L ENAH ERG EVL FASLG FMN1 FMNL1 FMNL2 FMNL3 FN1 FNBP4 FRA10AC1 GAPDH HIPK1 HNRNPF HNRNPK HNRNPU HNRNPUL1 HSPB1 HSPG2 HTT IL1RAP KMT2B LARP7 LTBP3 MAP1LC3A MECP2 MMP11 NCKAP1L NKAP NKAPD1 NONO PCBP2 PDCD7 PECAM1 PFKL PIAS1 PIAS3 PIAS4 PICK1 PPIG PRKAR1A PSG5 PTBP1 PTPRF RBM39 RBMX2 RCC2 RLF RNF10 RPL4 RPLP0 SDCBP SDCBP2 SDK1 SERPINB9 SF1 SF3A1 SF3A2 SF3A3 SF3B2 SF3B3 SFPQ SMAD4 SNIP1 SNRNP70 SON SPMIP2 SREK1 SREK1IP1 SRPK2 STIM2 TCEAL9 TMEM132D U2AF1 U2AF2 U2SURP UBE2I UBE2K UBQLN1 UBQLN2 UBQLN4 UBR4 USP7 VASP VCL WAS WASF2 WASL WBP11 WBP4 WIPF1 XRCC6 YBX1 YLPM1 YWHAG ZCCHC10 ZCCHC8 ZFHX3 ZHX1 ZNF341 ZNF451	8 interacting genes: ANXA1 CEBPA ERG PRPF40A PTEN RAC1 RNF26 USP7
Entrez ID		55660	55920
HPRD ID		10995	18171
Ensembl ID		ENSG00000196504	ENSG00000179051
Uniprot IDs		A0A7N4I394 A0A8Q3SIG7 A0A8V8TM61 F5H578 O75400	A0A024RAC5 Q9P258
PDB IDs		1UZC 1YWI 1YWJ 1ZR7 2CQN 2DYF 2KZG 2L5F 2L9V 2LKS 8PXW 8PXX	5GWN
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Nuclear Speck Nucleic Acid Binding Spliceosomal Complex Nucleoplasm Nucleus Spliceosomal Complex Assembly RNA Metabolic Process U2 SnRNP Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly Actin Binding U2-type Precatalytic Spliceosome Profilin Binding SCAR Complex Cellular Component Assembly Actin Polymerization Or Depolymerization Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Ribonucleoprotein Complex MRNA 3'-splice Site Recognition Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein-RNA Complex Assembly Actin Filament-based Process Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Metabolic Process Protein Binding Alternative MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of Macromolecule Metabolic Process PML Body SUMO Ligase Activity Cytosol U2-type Spliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process Actin Cytoskeleton Organization Focal Adhesion Regulation Of Metabolic Process U2-type Prespliceosome CRD-mediated MRNA Stability Complex	Organelle Organization Regulation Of Cell Shape Regulation Of Ubiquitin-dependent Protein Catabolic Process Phagocytic Cup Regulation Of Cell Morphogenesis Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Regulation Of Gene Expression Regulation Of Anatomical Structure Morphogenesis Cell Migration Macromolecule Metabolic Process Actin Filament Negative Regulation Of Cell Development Negative Regulation Of Transport Cytoskeleton Organization Cell Motility Regulation Of Cell Cycle RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Cell-substrate Junction Organization Regulation Of Focal Adhesion Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Hemopoiesis Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelial Cell Migration Multicellular Organismal-level Homeostasis CHOP-C/EBP Complex PML Body Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Wound Healing Response To Glucocorticoid
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