SMAD4 and PAPPA2

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		SMAD4	PAPPA2
Description		SMAD family member 4	pappalysin 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Activin Responsive Factor Complex Protein-containing Complex Ciliary Basal Body SMAD Protein Complex Heteromeric SMAD Protein Complex RNA Polymerase II Transcription Regulator Complex	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Collagen Binding Filamin Binding Identical Protein Binding Protein Homodimerization Activity Sulfate Binding Sequence-specific DNA Binding Protein-containing Complex Binding SMAD Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding I-SMAD Binding R-SMAD Binding	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Development Osteoblast Differentiation Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Gastrulation With Mouth Forming Second Kidney Development Epithelial To Mesenchymal Transition Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Left Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Septum Development Brainstem Development DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Single Fertilization Gastrulation Axon Guidance Endoderm Development Mesoderm Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Female Gonad Development Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Epithelial Cell Migration Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Neural Crest Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Cell Differentiation Negative Regulation Of Cell Growth Adrenal Gland Development BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somite Rostral/caudal Axis Specification Regulation Of Transforming Growth Factor Beta2 Production Activin Receptor Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Intracellular Signal Transduction Atrioventricular Canal Development Endothelial Cell Activation Regulation Of Cell Population Proliferation Negative Regulation Of Protein Catabolic Process Embryonic Digit Morphogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Follicle-stimulating Hormone Secretion Mesendoderm Development Developmental Growth Neuron Fate Commitment Neuron Fate Specification Tissue Morphogenesis Sebaceous Gland Development Formation Of Anatomical Boundary Regulation Of Hair Follicle Development Uterus Development Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Endocardial Cell Differentiation Female Gonad Morphogenesis Secondary Palate Development Interleukin-6-mediated Signaling Pathway ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis Seminiferous Tubule Development Regulation Of Primary Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Myofibril Assembly	Regulation Of Cell Growth Proteolysis Cell Surface Receptor Signaling Pathway Response To Salt Stress Bone Morphogenesis
Pathways		Signaling by NODAL Signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases RUNX2 regulates bone development RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Cardiogenesis SARS-CoV-1 targets host intracellular signalling and regulatory pathways Germ layer formation at gastrulation Formation of definitive endoderm Formation of definitive endoderm TGFBR3 expression Transcriptional regulation of brown and beige adipocyte differentiation by EBF2	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs
Diseases		Colorectal cancer Juvenile polyposis syndrome Hereditary hemorrhagic telangiectasia (HHT) Pancreatic cancer
GWAS		Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Oligoclonal band status in multiple sclerosis ( 25616667)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Automobile speeding propensity ( 30643258) Birth weight ( 31043758) Body mass index ( 26426971) Fractional exhaled nitric oxide (childhood) ( 24315451) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Height ( 25429064 20881960 31562340) Hip circumference adjusted for BMI ( 34021172) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Offspring birth weight ( 31043758) Pediatric central nervous system tumors (late onset)(pleiotropy) ( 33226468) Pediatric central nervous system tumors (pleiotropy) ( 33226468) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407) Pulse pressure ( 30578418 27841878) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		212 interacting genes: ACVR1B AKT1 ALDOB AOPEP AP2B1 APBB2 AR ARFRP1 ARL5B ATF2 ATF7IP BAAT BCAS3 BEX1 BRCA1 BTRC CAMK2G CCDC180 CD59 CDC14B CEBPA CEBPB CEBPD CHEK1 CITED1 CNKSR1 COPS5 CREBBP CSH1 CSH2 CTCF CTNNB1 CYFIP2 DACH1 DCP1A DCP1B DKK3 DLX1 DNAJB2 DNMT3L DVL1 ECSIT EEF1A1 EID2 EIF2AK4 EP300 ERBIN ESR1 ESR2 ETV4 EWSR1 FANCC FBLN1 FBP2 FBXO30 FBXO34 FHL2 FHL3 FN1 FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 FSTL3 GATA2 GLI3 GPNMB GREB1 HDGF HDLBP HEMGN HMG20A HNF4A HOXA9 HOXC8 HRAS HYAL2 IL24 ITK JUN JUNB JUND LAMTOR5 LEF1 LMO4 LRATD2 LYPD3 MAPK1 MAPK13 MAX MDM4 MECOM MEF2A MEX3B MSANTD3 MYOD1 NAT8 NEK6 NELFCD NFKBID NKX3-2 NOTCH4 NR0B2 NRAS NUAK2 NUP214 OTUB1 PAK1 PAPPA2 PARD3 PBK PIAS1 PIAS2 PIAS3 PIAS4 PLG PLK4 PPP2CB PPP3R2 PRKAR1B PRKAR2A PRPF40A PSG2 PSG9 PSMD11 RAB13 RAB25 RAB2B RAB34 RAB38 RAB3B RAC2 RALA RASD2 RASL12 RASSF5 RBL1 RFX1 RHEBL1 RHOD RHOG RHOJ RIPK2 RMND5B RPL28 RPS27A RRAS2 RSPH14 S100A14 SASH3 SERPINA1 SERPINB5 SFRP2 SFRP4 SHC1 SKI SKIL SKP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD7 SMAD9 SNIP1 SNRNP70 SNW1 SOX12 SP1 SPTBN1 SQSTM1 STK11IP STK35 STUB1 STX17 TCTA TDG TENM3 TFE3 TGFBR1 TGFBR2 TGFBRAP1 THRSP TLE5 TM9SF2 TOB1 TRAP1 TRIP12 TSSK3 TSTD2 UBA52 UBB UBE2I UBE2L3 UBE2Z UHRF2 USB1 USP10 USP4 USP9X WWOX XPO5 ZBED5 ZBTB7A ZIC1 ZMYM2 ZNF189 ZNF423 ZNF510 ZNF521 ZNF8	5 interacting genes: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B
Entrez ID		4089	60676
HPRD ID		02995	10156
Ensembl ID		ENSG00000141646	ENSG00000116183
Uniprot IDs		A0A024R274 Q13485	Q9BXP8
PDB IDs		1DD1 1G88 1MR1 1U7F 1U7V 1YGS 5C4V 5MEY 5MEZ 5MF0 5UWU 6YIC	8SL1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus SMAD Binding Nucleoplasm Intracellular Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ubiquitin Protein Ligase Binding Enzyme-linked Receptor Protein Signaling Pathway DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Regulation Of Signaling Regulation Of Cell Communication RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding I-SMAD Binding Intracellular Signaling Cassette Cell Surface Receptor Signaling Pathway Chromatin Cell Differentiation SMAD Protein Signal Transduction	Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Insulin-like Growth Factor II Binding Osteoblast Differentiation Insulin-like Growth Factor Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Type B Pancreatic Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Fibronectin Binding Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Muscle Hypertrophy Growth Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Regulation Of MiRNA Transcription Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of MiRNA Metabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of Growth Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Cell Population Proliferation Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epithelial Cell Proliferation Protein Tyrosine Phosphatase Activator Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Macromolecule Biosynthetic Process Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Negative Regulation Of Biosynthetic Process Sulfate Binding Endocardial Cell Differentiation Regulation Of Primary Metabolic Process MAPK Cascade Negative Regulation Of Growth Regulation Of Muscle System Process Transcription Regulator Complex SMAD Protein Complex
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