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SMAD4 and UBA52
Number of citations of the paper that reports this interaction (PubMedID
15761153
)
0
Data Source:
HPRD
(in vivo)
SMAD4
UBA52
Description
SMAD family member 4
ubiquitin A-52 residue ribosomal protein fusion product 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Centrosome
Cytosol
Activin Responsive Factor Complex
Protein-containing Complex
Ciliary Basal Body
SMAD Protein Complex
Heteromeric SMAD Protein Complex
RNA Polymerase II Transcription Regulator Complex
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosomal Membrane
Endoplasmic Reticulum Membrane
Cytosol
Ribosome
Plasma Membrane
Endosome Membrane
Large Ribosomal Subunit
Cytosolic Large Ribosomal Subunit
Cytosolic Ribosome
Endocytic Vesicle Membrane
Vesicle
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Collagen Binding
Filamin Binding
Identical Protein Binding
Protein Homodimerization Activity
Sulfate Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
SMAD Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
I-SMAD Binding
R-SMAD Binding
Structural Constituent Of Ribosome
Protein Binding
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ovarian Follicle Development
Osteoblast Differentiation
Branching Involved In Ureteric Bud Morphogenesis
Response To Hypoxia
In Utero Embryonic Development
Gastrulation With Mouth Forming Second
Kidney Development
Epithelial To Mesenchymal Transition
Outflow Tract Septum Morphogenesis
Cardiac Conduction System Development
Atrioventricular Valve Formation
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Left Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Cardiac Septum Development
Brainstem Development
DNA-templated Transcription
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
Spermatogenesis
Single Fertilization
Gastrulation
Axon Guidance
Endoderm Development
Mesoderm Development
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Female Gonad Development
Anatomical Structure Morphogenesis
Anterior/posterior Pattern Specification
Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Epithelial Cell Migration
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Neural Crest Cell Differentiation
Cardiac Muscle Hypertrophy In Response To Stress
Cell Differentiation
Negative Regulation Of Cell Growth
Adrenal Gland Development
BMP Signaling Pathway
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Somite Rostral/caudal Axis Specification
Regulation Of Transforming Growth Factor Beta2 Production
Activin Receptor Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Intracellular Signal Transduction
Atrioventricular Canal Development
Endothelial Cell Activation
Regulation Of Cell Population Proliferation
Negative Regulation Of Protein Catabolic Process
Embryonic Digit Morphogenesis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Follicle-stimulating Hormone Secretion
Mesendoderm Development
Developmental Growth
Neuron Fate Commitment
Neuron Fate Specification
Tissue Morphogenesis
Sebaceous Gland Development
Formation Of Anatomical Boundary
Regulation Of Hair Follicle Development
Uterus Development
Positive Regulation Of SMAD Protein Signal Transduction
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Endocardial Cell Differentiation
Female Gonad Morphogenesis
Secondary Palate Development
Interleukin-6-mediated Signaling Pathway
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Glucose Stimulus
Cellular Response To Growth Factor Stimulus
Response To Transforming Growth Factor Beta
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Metanephric Mesenchyme Morphogenesis
Nephrogenic Mesenchyme Morphogenesis
Seminiferous Tubule Development
Regulation Of Primary Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Extracellular Matrix Assembly
Positive Regulation Of MiRNA Transcription
Negative Regulation Of Cardiac Myofibril Assembly
Cytoplasmic Translation
Translation
Protein Ubiquitination
Response To Insecticide
Modification-dependent Protein Catabolic Process
Protein Modification Process
Pathways
Signaling by NODAL
Signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TGF-beta receptor signaling activates SMADs
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD4 MH2 Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
Transcriptional regulation of pluripotent stem cells
Ub-specific processing proteases
RUNX2 regulates bone development
RUNX3 regulates CDKN1A transcription
RUNX3 regulates BCL2L11 (BIM) transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
FOXO-mediated transcription of cell cycle genes
FOXO-mediated transcription of cell cycle genes
Cardiogenesis
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
Germ layer formation at gastrulation
Formation of definitive endoderm
Formation of definitive endoderm
TGFBR3 expression
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Viral mRNA Translation
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Selenocysteine synthesis
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Major pathway of rRNA processing in the nucleolus and cytosol
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
VLDLR internalisation and degradation
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Interferon alpha/beta signaling
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Response of EIF2AK4 (GCN2) to amino acid deficiency
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Signaling by CSF1 (M-CSF) in myeloid cells
Maturation of protein E
SARS-CoV-1 activates/modulates innate immune responses
Maturation of protein E
Inactivation of CSF3 (G-CSF) signaling
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Negative regulation of FLT3
FLT3 signaling by CBL mutants
Regulation of BACH1 activity
Signaling by ALK fusions and activated point mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
KEAP1-NFE2L2 pathway
Regulation of NF-kappa B signaling
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Amyloid fiber formation
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Antigen processing: Ubiquitination & Proteasome degradation
Evasion by RSV of host interferon responses
Regulation of pyruvate metabolism
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
PD-L1(CD274) glycosylation and translocation to plasma membrane
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
Colorectal cancer
Juvenile polyposis syndrome
Hereditary hemorrhagic telangiectasia (HHT)
Pancreatic cancer
GWAS
Asthma (
30929738
32296059
)
Asthma (childhood onset) (
30929738
)
Asthma onset (childhood vs adult) (
30929738
)
Immune response to anthrax vaccine (
22658931
)
Metabolite levels (
23823483
)
Oligoclonal band status in multiple sclerosis (
25616667
)
Interacting Genes
212 interacting genes:
ACVR1B
AKT1
ALDOB
AOPEP
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BAAT
BCAS3
BEX1
BRCA1
BTRC
CAMK2G
CCDC180
CD59
CDC14B
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DKK3
DLX1
DNAJB2
DNMT3L
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBIN
ESR1
ESR2
ETV4
EWSR1
FANCC
FBLN1
FBP2
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
GREB1
HDGF
HDLBP
HEMGN
HMG20A
HNF4A
HOXA9
HOXC8
HRAS
HYAL2
IL24
ITK
JUN
JUNB
JUND
LAMTOR5
LEF1
LMO4
LRATD2
LYPD3
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MSANTD3
MYOD1
NAT8
NEK6
NELFCD
NFKBID
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PPP2CB
PPP3R2
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
S100A14
SASH3
SERPINA1
SERPINB5
SFRP2
SFRP4
SHC1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
STX17
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
THRSP
TLE5
TM9SF2
TOB1
TRAP1
TRIP12
TSSK3
TSTD2
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP10
USP4
USP9X
WWOX
XPO5
ZBED5
ZBTB7A
ZIC1
ZMYM2
ZNF189
ZNF423
ZNF510
ZNF521
ZNF8
44 interacting genes:
ACVR1
ARRDC3
BMPR1B
DAZAP2
DESI1
DNAJB2
EPN2
EPN3
FAM168A
FILNC1
FNDC3B
FSHR
GRB2
HERC3
HGS
KHDRBS1
LAPTM5
LITAF
MAPK6
MTURN
NCK1
PLEKHB2
PLSCR4
POLI
RABGEF1
RAD23A
RNF11
SEC23B
SLC2A4
SMAD1
SMAD2
SMAD4
SMURF1
SNCA
SQSTM1
TAX1BP1
TGFBR1
TSG101
UBQLN1
UBQLN2
USP46
USP7
VPS28
WBP2
Entrez ID
4089
7311
HPRD ID
02995
08931
Ensembl ID
ENSG00000141646
ENSG00000221983
Uniprot IDs
A0A024R274
Q13485
P62987
Q3MIH3
Q7Z4P3
PDB IDs
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
5C4V
5MEY
5MEZ
5MF0
5UWU
6YIC
2LJ5
2MBH
2MJB
2MUR
2N3U
2N3V
2N3W
2NBD
2NBE
2RSU
4HJK
4JIO
4P4H
4PIG
4PIH
4PIJ
4RF0
4RF1
4S1Z
4UG0
4V6X
4XKL
5AJ0
5GO7
5GO8
5GOB
5GOC
5GOD
5GOG
5GOH
5GOI
5GOJ
5GOK
5HPK
5HPL
5HPS
5HPT
5J26
5J8P
5JBV
5JBY
5LKS
5T2C
6IP5
6IP6
6IP8
6LQM
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
7AY1
7BHP
7F5S
7M3Q
7OWC
7UN3
7WFC
7XD0
7XNX
7XNY
7ZF1
7ZH3
7ZH4
8A3D
8IFD
8IFE
8IK6
8IKM
8IKT
8IKV
8IPJ
8JDJ
8JDK
8JDL
8JDM
8K2C
8OHD
8OJ0
8OJ5
8OJ8
8QFD
8QOI
8QYX
8UKB
8XSX
8XSY
8XSZ
8Y0W
8Y0X
8YOO
8YOP
9C3H
9G8M
9GMO
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Transcription Regulator Complex
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
SMAD Binding
Nucleoplasm
Intracellular Signal Transduction
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Signal Transduction
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Ubiquitin Protein Ligase Binding
Enzyme-linked Receptor Protein Signaling Pathway
DNA-binding Transcription Factor Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
I-SMAD Binding
Intracellular Signaling Cassette
Cell Surface Receptor Signaling Pathway
Chromatin
Cell Differentiation
SMAD Protein Signal Transduction
Endosome
I-SMAD Binding
SMAD Binding
Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Establishment Of Protein Localization To Vacuole
Regulation Of Cell Communication
Regulation Of Signaling
Negative Regulation Of Signal Transduction
Regulation Of Protein Catabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Metabolic Process
Protein Localization To Vacuole
Transforming Growth Factor Beta Receptor Activity, Type I
Ubiquitin Binding
Protein-containing Complex
Positive Regulation Of Macromolecule Metabolic Process
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Protein Complex
Regulation Of Protein Ubiquitination
Heteromeric SMAD Protein Complex
Ubiquitin Protein Ligase Binding
Cytoplasm
Activin Receptor Signaling Pathway
Positive Regulation Of Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Primary Metabolic Process
Modification-dependent Protein Catabolic Process
BMP Signaling Pathway
Polyubiquitin Modification-dependent Protein Binding
Regulation Of Post-translational Protein Modification
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Vacuolar Transport
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Protein Sequestering Activity
Enzyme-linked Receptor Protein Signaling Pathway
Regulation Of Proteolysis
Proteolysis
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Homomeric SMAD Protein Complex
Positive Regulation Of Ubiquitin-dependent Endocytosis
Regulation Of Metabolic Process
Proteolysis Involved In Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Targeting To Vacuole
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Tagcloud (Intersection)
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