Gene Name |
SMAD family member 4 |
estrogen receptor 1 |
Image |
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Gene Ontology Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- Diethylstilbestrol
- Chlorotrianisene
- Conjugated Estrogens
- Etonogestrel
- Desogestrel
- Levonorgestrel
- Progesterone
- Raloxifene
- Toremifene
- Medroxyprogesterone
- Estrone
- Tamoxifen
- Estradiol
- Ethynodiol Diacetate
- Clomifene
- Dienestrol
- Fulvestrant
- Norgestimate
- Ethinyl Estradiol
- Melatonin
- Trilostane
- Naloxone
- Fluoxymesterone
- Estramustine
- Mestranol
- Danazol
- Allylestrenol
- Genistein
- Compound 19
- Compound 18
- Compound 4-D
- 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol
- 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol
- Estriol
- Estropipate
- Quinestrol
- Ospemifene
- 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
- 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol
- [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
- 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL
- (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
- (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL
- 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
- 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
- dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol
- 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL
- DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE
- 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
- 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL
- RALOXIFENE CORE
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Diseases |
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GWAS |
- Immune response to anthrax vaccine ( 22658931)
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Protein-Protein Interactions |
174 interactors:
ACVR1B
AKT1
AP2B1
APBB2
AR
ARFRP1
ARL5B
ATF2
ATF7IP
BRCA1
BTRC
CAMK2G
CD59
CEBPA
CEBPB
CEBPD
CHEK1
CITED1
CNKSR1
COPS5
CREBBP
CSH1
CSH2
CTCF
CTNNB1
CYFIP2
DACH1
DCP1A
DCP1B
DLX1
DNAJB2
DVL1
ECSIT
EEF1A1
EID2
EIF2AK4
EP300
ERBB2IP
ESR1
ESR2
EWSR1
FBLN1
FBXO30
FBXO34
FHL2
FHL3
FN1
FOXG1
FOXH1
FOXO1
FOXO3
FOXO4
FSTL3
GATA2
GLI3
GPNMB
HDGF
HDLBP
HMG20A
HNF4A
HOXA9
HOXC8
ITK
JUN
JUNB
JUND
LEF1
LMO4
MAPK1
MAPK13
MAX
MDM4
MECOM
MEF2A
MEX3B
MYOD1
NAT8
NEK6
NELFCD
NF1
NKX3-2
NOTCH4
NR0B2
NRAS
NUAK2
NUP214
OTUB1
PAK1
PAPPA2
PARD3
PARD3B
PBK
PIAS1
PIAS2
PIAS3
PIAS4
PLG
PLK4
PRKAR1B
PRKAR2A
PRPF40A
PSG2
PSG9
PSMD11
RAB13
RAB25
RAB2B
RAB34
RAB38
RAB3B
RAC2
RALA
RASD2
RASL12
RASSF5
RBL1
RELA
RFX1
RHEBL1
RHOD
RHOG
RHOJ
RIPK2
RMND5B
RPL28
RPS27A
RRAS2
RSPH14
SASH3
SERPINA1
SKI
SKIL
SKP2
SMAD1
SMAD2
SMAD3
SMAD5
SMAD7
SMAD9
SNIP1
SNRNP70
SNW1
SOX12
SP1
SPTBN1
SQSTM1
STK11IP
STK35
STUB1
TCTA
TDG
TENM3
TFE3
TGFBR1
TGFBR2
TGFBRAP1
TM9SF2
TOB1
TRAP1
TSSK3
UBA52
UBB
UBE2I
UBE2L3
UBE2Z
UHRF2
USB1
USP9X
XPO5
ZBED5
ZMYM2
ZNF423
ZNF521
ZNF8
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266 interactors:
ACTN4
AHR
AKAP13
AKT1
AKT2
AR
ARHGEF15
ARNT
ATAD2
BAG1
BCAR1
BCAS2
BDNF
BRCA1
BTF3
CALM1
CALM2
CALM3
CAV1
CBLL1
CCNC
CCND1
CCNH
CCNT1
CDC25B
CDK2
CDK7
CDK8
CDKN1A
CEBPA
CEBPB
CHD9
CHUK
CITED1
COPS5
CREBBP
CSNK2B
CTNNB1
CUEDC2
CUL4B
DAP3
DDX5
DDX54
DNTTIP2
DUT
EGFR
EHMT2
EIF3I
EP300
ERBB2
ESR2
ESRRA
FHL2
FKBP4
FKBP5
FLII
FOXO1
FOXO3
FOXO4
GADD45B
GADD45G
GNAI1
GNAI2
GNAI3
GRB2
GRIP1
GTF2B
GTF2H1
HDAC4
HDAC5
HDAC9
HEXIM1
HNF4A
HSP90AA1
HSP90AB1
HSPA4
HSPA8
IGF1R
ING1
ISL1
ITGB3BP
JUN
JUNB
JUND
KAT5
KDM5A
KIF1A
KLF5
KMT2D
LCK
LCOR
LDB1
LINC00312
LRIF1
MAPK1
MAPK14
MAPK3
MDM2
MED1
MED10
MED12
MED13
MED14
MED16
MED17
MED20
MED21
MED23
MED24
MED25
MED6
MED7
MEN1
MGMT
MKNK2
MMS19
MNAT1
MPG
MSH2
MTA1
MTA2
MTA3
MTCH2
MUC1
MVP
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOA7
NCOR1
NCOR2
NELFB
NFKB1
NPPA
NR0B1
NR0B2
NR1H4
NR2C1
NR2C2
NR2F1
NR2F6
NRIP1
NSD1
OTUB1
PAGR1
PAK1
PAK6
PELP1
PGC
PGR
PHB
PHB2
PIAS1
PIAS2
PIAS3
PIK3R1
PIK3R3
PNRC2
POLR1B
POLR2D
POU2F1
POU2F2
POU4F1
POU4F2
PPARG
PPARGC1A
PPARGC1B
PPID
PRDM2
PRKACA
PRMT1
PRMT2
PRPF6
PSMC5
PTEN
PTGES3
PTMA
PTPN1
PTPN6
RAC3
RANBP9
RARA
RBBP4
RBBP7
RBFOX2
RBM23
RBM39
RELA
REXO4
RFX4
RGS3
RLIM
RNF14
RNF4
RPS6KA1
RPS6KA3
RXRA
SAFB
SAFB2
SETD7
SF1
SHC1
SKIL
SKP2
SLC30A9
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMARCD1
SMARCD3
SMARCE1
SMURF1
SMYD2
SOS1
SP1
SP3
SRA1
SRC
SREBF1
STAT5A
STRN
STUB1
SUMO1
SUV39H1
SUV420H1
SVIL
TAB2
TADA3
TAF10
TAF1A
TAF1B
TAF2
TAP1
TBP
TCF20
TDG
THRA
THRB
TNFRSF14
TP53
TRAM1
TRIM24
TRIM25
TRIM28
TRIM59
TRIP4
TRRAP
TSC2
TUBA1B
TUBB
UBE2I
UIMC1
USF1
VAV3
WHSC1
WIPI1
XBP1
YWHAH
YWHAQ
ZBTB16
ZBTB17
ZNF398
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Entrez ID |
4089 |
2099 |
HPRD ID |
02995 |
00589 |
Ensembl ID |
ENSG00000141646
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ENSG00000091831
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Uniprot IDs |
Q13485
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G4XH65
P03372
Q9UBT1
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PDB IDs |
1DD1
1G88
1MR1
1U7F
1U7V
1YGS
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1A52
1AKF
1ERE
1ERR
1G50
1GWQ
1GWR
1HCP
1HCQ
1L2I
1PCG
1QKT
1QKU
1R5K
1SJ0
1UOM
1X7E
1X7R
1XP1
1XP6
1XP9
1XPC
1XQC
1YIM
1YIN
1ZKY
2AYR
2B1V
2B1Z
2B23
2BJ4
2FAI
2G44
2G5O
2I0J
2IOG
2IOK
2JF9
2JFA
2LLO
2LLQ
2OCF
2OUZ
2P15
2POG
2Q6J
2Q70
2QA6
2QA8
2QAB
2QE4
2QGT
2QGW
2QH6
2QR9
2QSE
2QXM
2QXS
2QZO
2R6W
2R6Y
2YAT
2YJA
3CBM
3CBO
3CBP
3DT3
3ERD
3ERT
3HLV
3HM1
3L03
3OS8
3OS9
3OSA
3Q95
3Q97
3UU7
3UUA
3UUC
3UUD
4AA6
4DMA
4IU7
4IUI
4IV2
4IV4
4IVW
4IVY
4IW6
4IW8
4IWC
4IWF
4JC3
4JDD
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
adenoviral
autoinhibitory
cdk
coactivators
competing
conformational
constructs
creb
define
e1a
effector
facilitating
fragment
interacting
modulates
oncoprotein
p15
p300
participate
possibility
potentiates
removes
smad3
smads
squelching
tgf
transactivation
transduce
|
analyzing
brca1
carcinogenic
changed
characters
coactivator
concordant
conduct
differentiationassociated
discovered
downloaded
e2
enrichment
estradiol
go
gses9623
gsm986085
gsm986087
guidance
macs
mcf7
omnibus
ontology
p300bound
p300regulated
participated
peakcalling
software
theoretical
|
Tagcloud (Difference) ? |
adenoviral
autoinhibitory
cdk
coactivators
competing
conformational
constructs
creb
define
e1a
effector
facilitating
fragment
interacting
modulates
oncoprotein
p15
p300
participate
possibility
potentiates
removes
smad3
smads
squelching
tgf
transactivation
transduce
|
analyzing
brca1
carcinogenic
changed
characters
coactivator
concordant
conduct
differentiationassociated
discovered
downloaded
e2
enrichment
estradiol
go
gses9623
gsm986085
gsm986087
guidance
macs
mcf7
omnibus
ontology
p300bound
p300regulated
participated
peakcalling
software
theoretical
|
Tagcloud (Intersection) ? |
|