SMAD4 and CEBPA

Number of citations of the paper that reports this interaction (PMID 12524424)
50

Data Source:
BioGRID (pull down)

		SMAD4	CEBPA
Gene Name		SMAD family member 4	CCAAT/enhancer binding protein (C/EBP), alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome Cytosol Activin Responsive Factor Complex SMAD Protein Complex	Nucleus Nuclear Matrix Rb-E2F Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Core Promoter Proximal Region Sequence-specific DNA Binding Protein Binding Transcription Factor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Factor Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Collagen Binding Transforming Growth Factor Beta Receptor, Common-partner Cytoplasmic Mediator Activity Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding I-SMAD Binding R-SMAD Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Complex Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Branching Involved In Ureteric Bud Morphogenesis Response To Hypoxia In Utero Embryonic Development Gastrulation With Mouth Forming Second Atrioventricular Valve Formation Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Cardiac Septum Development Brainstem Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Axon Guidance Endoderm Development Mesoderm Development Cell Proliferation Negative Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Somite Rostral/caudal Axis Specification Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Maintenance Intracellular Signal Transduction Atrioventricular Canal Development Endothelial Cell Activation Negative Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Developmental Growth Neuron Fate Commitment Sebaceous Gland Development Formation Of Anatomical Boundary Regulation Of Binding Regulation Of Hair Follicle Development Palate Development Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Negative Regulation Of Cell Death Endocardial Cell Differentiation Response To Transforming Growth Factor Beta Metanephric Mesenchyme Morphogenesis Nephrogenic Mesenchyme Morphogenesis	Urea Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Embryonic Placenta Development Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Mitochondrion Organization Cholesterol Metabolic Process Negative Regulation Of Cell Proliferation Viral Process Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Macrophage Differentiation Lung Development Organ Regeneration Response To Vitamin B2 Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Cell Maturation Inner Ear Development White Fat Cell Differentiation Brown Fat Cell Differentiation Response To Glucocorticoid Cellular Response To Lithium Ion Cellular Response To Organic Cyclic Compound
Pathways		Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by BMP Transcriptional regulation of pluripotent stem cells Generic Transcription Pathway Signaling by NODAL TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer Signaling by Activin TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Immune response to anthrax vaccine ( 22658931)
Protein-Protein Interactions		174 interactors: ACVR1B AKT1 AP2B1 APBB2 AR ARFRP1 ARL5B ATF2 ATF7IP BRCA1 BTRC CAMK2G CD59 CEBPA CEBPB CEBPD CHEK1 CITED1 CNKSR1 COPS5 CREBBP CSH1 CSH2 CTCF CTNNB1 CYFIP2 DACH1 DCP1A DCP1B DLX1 DNAJB2 DVL1 ECSIT EEF1A1 EID2 EIF2AK4 EP300 ERBB2IP ESR1 ESR2 EWSR1 FBLN1 FBXO30 FBXO34 FHL2 FHL3 FN1 FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 FSTL3 GATA2 GLI3 GPNMB HDGF HDLBP HMG20A HNF4A HOXA9 HOXC8 ITK JUN JUNB JUND LEF1 LMO4 MAPK1 MAPK13 MAX MDM4 MECOM MEF2A MEX3B MYOD1 NAT8 NEK6 NELFCD NF1 NKX3-2 NOTCH4 NR0B2 NRAS NUAK2 NUP214 OTUB1 PAK1 PAPPA2 PARD3 PARD3B PBK PIAS1 PIAS2 PIAS3 PIAS4 PLG PLK4 PRKAR1B PRKAR2A PRPF40A PSG2 PSG9 PSMD11 RAB13 RAB25 RAB2B RAB34 RAB38 RAB3B RAC2 RALA RASD2 RASL12 RASSF5 RBL1 RELA RFX1 RHEBL1 RHOD RHOG RHOJ RIPK2 RMND5B RPL28 RPS27A RRAS2 RSPH14 SASH3 SERPINA1 SKI SKIL SKP2 SMAD1 SMAD2 SMAD3 SMAD5 SMAD7 SMAD9 SNIP1 SNRNP70 SNW1 SOX12 SP1 SPTBN1 SQSTM1 STK11IP STK35 STUB1 TCTA TDG TENM3 TFE3 TGFBR1 TGFBR2 TGFBRAP1 TM9SF2 TOB1 TRAP1 TSSK3 UBA52 UBB UBE2I UBE2L3 UBE2Z UHRF2 USB1 USP9X XPO5 ZBED5 ZMYM2 ZNF423 ZNF521 ZNF8	56 interactors: AR ATF2 ATF3 ATF4 ATF5 BATF BATF2 BATF3 C1QBP CDK2 CDK4 CDKN1A CDKN3 CDX1 CEBPB CEBPD CEBPE CEBPG CREBBP CTNNB1 DBP EDF1 EP300 ESR1 FOS FOSL1 GATA2 GSK3B HNF1A MAPK8 MSX2 MYC NCOA6 NFYA NR3C1 PIAS1 RARA RARB RASGRF1 RB1 RBL1 RFC1 RUNX1 SKP2 SMAD3 SMAD4 SMARCA2 SMARCA4 SOX10 SOX8 SPI1 SRA1 SUMO3 XRCC5 XRCC6 ZBTB16
Entrez ID		4089	1050
HPRD ID		02995	00296
Ensembl ID		ENSG00000141646	ENSG00000245848
Uniprot IDs		Q13485	P49715
PDB IDs		1DD1 1G88 1MR1 1U7F 1U7V 1YGS
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Enzyme Linked Receptor Protein Signaling Pathway Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Cellular Response To Stimulus Response To Organic Substance Response To Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Cell Communication Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Signaling Response To Transforming Growth Factor Beta Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process	Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Organ Development Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated System Development Multicellular Organismal Development Cellular Metabolic Process Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Cell Differentiation Regulation Of Cell Proliferation Regulation Of Cell Differentiation Tissue Development Myeloid Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Death Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?		adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad3 smads squelching tgf transactivation transduce	acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust
Tagcloud (Difference) ?		adenoviral autoinhibitory cdk coactivators competing conformational constructs creb define e1a effector facilitating fragment interacting modulates oncoprotein p15 p300 participate possibility potentiates removes smad3 smads squelching tgf transactivation transduce	acting additive c38 c40 caat cebpb collectively commitment composed concert elusive embryonic enhancer epidermis evolutionary fate keratinocyte keratinocytes layer modules p63 p63lre partly pluripotent pou pou3f1 redundant repress robust
Tagcloud (Intersection) ?