LYL1 and RHOU

Number of citations of the paper that reports this interaction (PubMedID 26598620)
63

Data Source:
BioGRID (pull down)

		LYL1	RHOU
Description		LYL1 basic helix-loop-helix family member	ras homolog family member U
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Golgi Membrane Podosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Endosome Membrane Membrane Cell Projection Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Metal Ion Binding
	Biological Process	Blood Vessel Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of DNA-templated Transcription Definitive Hemopoiesis	G1/S Transition Of Mitotic Cell Cycle Endocytosis Cytoskeleton Organization Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Rac Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Focal Adhesion Disassembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		NGF-stimulated transcription	Interleukin-4 and Interleukin-13 signaling RHOU GTPase cycle RHOU GTPase cycle
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Household income ( 31844048) Household income (MTAG) ( 31844048) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278)	Aging ( 22773346) Basal cell carcinoma ( 18849993 24403052 25855136 27539887 33549134) Chronic lymphocytic leukemia ( 28165464) Dental caries ( 23259602) Endometriosis ( 20844546) Leukoderma in response to rhododendrol ( 32558222) Mercury levels ( 26025379) Non-melanoma skin cancer ( 29739929) Response to antidepressants in depression ( 27622933) Type 2 diabetes ( 23300278)
Interacting Genes		8 interacting genes: DRG1 LMO1 LMO2 NFKB1 NFKBIA RHOU TCF3 TCF4	126 interacting genes: ACAD8 ADM2 ALG13 ANGPT4 ANXA4 ANXA6 AP1S1 ARHGEF25 AS3MT ATP5MG ATP6AP1 BDNF BMAL1 BNIPL BRF1 BRINP3 C14orf119 CDKL4 CFAP100 CHRNA4 CLEC7A CPNE3 CTCF CUL5 DACT2 DMRT2 DNM2 DOK4 DSCR8 EIF4B ELP5 EMC2 ERF ERO1A FAM110B FCHO2 FKBP15 GALNTL5 GLI3 GPRIN2 GRB2 H2BC14 HCAR1 HINT3 HSD17B13 ID2 IFFO1 IL17F INSM2 JAM3 KAAG1 KIAA1191 KLRC3 LANCL2 LARS2 LAYN LMO7 LYL1 ME3 MOS MRAS MRPL15 NCK1 NCR1 NPM3 NR1H2 NRBF2 NXPH4 OXCT2 P4HTM PAK1 PAK4 PCDHGA4 PDLIM3 PGK1 PIP5K1A PLCG1 PLEK PLOD3 POT1 PRB1 PRPF18 PSMA4 PXN QTRT1 RAB40A RAD51D RALBP1 RASSF1 RBIS RPL23AP5 RPS15A RPS17P16 S100A4 SEC14L4 SEMA3G SEPTIN6 SIVA1 SKIC2 SLC26A1 SNU13 SOX4 SSC4D STX16 SYK TCN2 TEKT2 TMEM106A TMEM169 TMEM255B TRIM59 USP37 UTP3 VWA5A WNT6 XPA ZFAND2B ZFP64 ZKSCAN7 ZNF117 ZNF177 ZNF20 ZNF569 ZNF625 ZNF747 ZNF84
Entrez ID		4066	58480
HPRD ID		01046	06965
Ensembl ID		ENSG00000104903	ENSG00000116574
Uniprot IDs		P12980	Q7L0Q8
PDB IDs			2Q3H
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II I-kappaB/NF-kappaB Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II BHLH Transcription Factor Binding Response To Muscle Stretch Positive Regulation Of Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Lipid Storage Protein Sequestering Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To DsRNA Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding B Cell Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction E-box Binding Tumor Necrosis Factor-mediated Signaling Pathway Histone H4K8ac Reader Activity Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Cholesterol Transport Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Immune System Process Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of DNA-templated Transcription Initiation NF-kappaB P50/p65 Complex Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Developmental Process Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Axonemal Microtubule Doublet Inner Sheath Positive Regulation Of Neuron Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin
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