LYL1 and DRG1

Number of citations of the paper that reports this interaction (PubMedID 8649774)
0

Data Source:
HPRD (in vitro)

		LYL1	DRG1
Description		LYL1 basic helix-loop-helix family member	developmentally regulated GTP binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Hydrolase Activity Potassium Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Blood Vessel Maturation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of DNA-templated Transcription Definitive Hemopoiesis	Cytoplasmic Translation Positive Regulation Of Microtubule Polymerization Regulation Of Mitotic Spindle Assembly
Pathways		NGF-stimulated transcription	Protein hydroxylation
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Household income ( 31844048) Household income (MTAG) ( 31844048) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278)	Fish- and plant-related diet ( 32066663) Neutrophil count ( 27863252 32888494) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Sum basophil neutrophil counts ( 27863252) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		8 interacting genes: DRG1 LMO1 LMO2 NFKB1 NFKBIA RHOU TCF3 TCF4	18 interacting genes: CAPNS1 CEBPA CFTR CLDN1 COIL LNX1 LYL1 MEOX2 PHC2 PTEN RWDD1 SKIL SRPK2 SSX2IP STK16 TAL1 UBE2I ZC3H15
Entrez ID		4066	4733
HPRD ID		01046	16034
Ensembl ID		ENSG00000104903	ENSG00000185721
Uniprot IDs		P12980	Q9Y295
PDB IDs			2EKI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription By RNA Polymerase II I-kappaB/NF-kappaB Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II BHLH Transcription Factor Binding Response To Muscle Stretch Positive Regulation Of Biosynthetic Process Regulation Of Macrophage Derived Foam Cell Differentiation Non-canonical NF-kappaB Signal Transduction Signal Transduction Involved In Regulation Of Gene Expression Regulation Of Lipid Storage Protein Sequestering Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Response To DsRNA Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Cis-regulatory Region Binding B Cell Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction E-box Binding Tumor Necrosis Factor-mediated Signaling Pathway Histone H4K8ac Reader Activity Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Cholesterol Transport Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Immune System Process Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of DNA-templated Transcription Initiation NF-kappaB P50/p65 Complex Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Developmental Process Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Axonemal Microtubule Doublet Inner Sheath Positive Regulation Of Neuron Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process	Developmental Maturation Response To Ketone Protein-containing Complex PDZ Domain Binding Definitive Hemopoiesis Lens Fiber Cell Differentiation Synapse Maturation Anatomical Structure Formation Involved In Morphogenesis PML Body Granulocyte Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of Cell Cycle Cell Maturation Enzyme Binding 14-3-3 Protein Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Synaptic Vesicle Clustering Hemangioblast Cell Differentiation SUMO Conjugating Enzyme Activity Xenobiotic Transport Across Blood-nerve Barrier Regulation Of Cell Population Proliferation Protein Domain Specific Binding Chromatin Binding Regulation Of RNA Metabolic Process Nucleus Regulation Of Cell Development Cellular Developmental Process Animal Organ Regeneration Response To Vitamin B2 Multicellular Organismal-level Homeostasis C/EBP Complex Identical Protein Binding Positive Regulation Of Anion Channel Activity Cell Junction Organization Negative Regulation Of Cell-substrate Adhesion Membrane Assembly Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Basophil Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Butyrate
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