LIMK1 and LATS1

Number of citations of the paper that reports this interaction (PMID 15220930)
32

Data Source:
HPRD (in vivo, in vitro)

		LIMK1	LATS1
Gene Name		LIM domain kinase 1	large tumor suppressor kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Focal Adhesion Neuron Projection	Spindle Pole Microtubule Organizing Center Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Heat Shock Protein Binding Protein Heterodimerization Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Positive Regulation Of Axon Extension Ephrin Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly	G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Protein Phosphorylation Mitotic Nuclear Division Hormone-mediated Signaling Pathway Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cytoplasmic Sequestering Of Protein Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema3A PAK dependent Axon repulsion Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System	Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 HIST1H1A LATS1 LIMK2 MAPK14 MAPKAPK2 MBP NRG1 PAK1 PAK2 PAK4 PXN RLIM ROCK1 SRPK1 SSH3 YWHAZ	43 interactors: ALPP AMOT APP AURKB CAV1 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 ITCH KRT31 LDOC1 LIMK1 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NUAK1 NUAK2 PABPN1 PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SPERT SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 WWOX WWP1 WWTR1 YAP1 ZYX
Entrez ID		3984	9113
HPRD ID		03210	09147
Ensembl ID		ENSG00000106683	ENSG00000131023
Uniprot IDs		P53667	O95835
PDB IDs		3S95
Enriched GO Terms of Interacting Partners?		Phosphorylation Cellular Protein Modification Process Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Signal Transduction By Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Protein Metabolic Process Platelet Activation Signaling Regulation Of Kinase Activity Cell Communication Response To External Stimulus Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction Cell Differentiation Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Organelle Organization Locomotion Immune Response Neurogenesis Apoptotic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Signaling Defense Response Programmed Cell Death Organelle Organization Immune System Process Regulation Of Protein Metabolic Process	Hippo Signaling Regulation Of Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Signaling Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Death Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Protein Binding Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Signaling Tissue Development Cellular Protein Catabolic Process Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Cellular Response To Growth Factor Stimulus Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Anatomical Structure Morphogenesis Regulation Of Kinase Activity Signal Transduction Response To Growth Factor Cell Communication Positive Regulation Of Signal Transduction Regulation Of Developmental Growth Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Cellular Macromolecule Catabolic Process Regulation Of Cell Development Negative Regulation Of Wnt Signaling Pathway Regulation Of Organ Growth Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845	accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours
Tagcloud (Difference) ?		alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845	accompanying carcinogenic cdc2 conservation corpus flies homologue hyperplastic hypogonadism hypogonadotropic infertility insufficiency lethality lh luteum mammalian melanogaster mosaic pituitary ref reminiscent reproductive rescues retardation sarcomas screens tumorigenesis tumours
Tagcloud (Intersection) ?