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LIMK1 and BMPR2
Number of citations of the paper that reports this interaction (PubMedID
12963706
)
35
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
LIMK1
BMPR2
Description
LIM domain kinase 1
bone morphogenetic protein receptor type 2
Image
GO Annotations
Cellular Component
Male Germ Cell Nucleus
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Focal Adhesion
Membrane
Nuclear Speck
Lamellipodium
Cell Junction
Cell Projection
Neuron Projection
Postsynapse
Glutamatergic Synapse
Extracellular Space
Nucleoplasm
Plasma Membrane
Caveola
Clathrin-coated Pit
Adherens Junction
Basal Plasma Membrane
Cell Surface
Postsynaptic Density
Membrane
Apical Plasma Membrane
Cell Junction
Axon
Dendrite
Neuronal Cell Body
Organelle
Receptor Complex
Cell Body
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Protein Serine Kinase Activity
Ubiquitin Ligase Inhibitor Activity
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Activin Receptor Activity, Type II
Transferase Activity
Growth Factor Binding
BMP Binding
Cadherin Binding
Metal Ion Binding
BMP Receptor Activity
Protein Tyrosine Kinase Binding
Biological Process
Protein Phosphorylation
Signal Transduction
Rho Protein Signal Transduction
Nervous System Development
Actin Cytoskeleton Organization
Positive Regulation Of Actin Filament Bundle Assembly
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Stress Fiber Assembly
Positive Regulation Of Axon Extension
Axon Extension
Positive Regulation Of Stress Fiber Assembly
Regulation Of Cell Growth
Blood Vessel Development
Osteoblast Differentiation
Mesoderm Formation
Maternal Placenta Development
Endothelial Cell Proliferation
Vasculature Development
Lymphangiogenesis
Blood Vessel Remodeling
Chondrocyte Development
Negative Regulation Of Systemic Arterial Blood Pressure
Outflow Tract Septum Morphogenesis
Outflow Tract Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Atrioventricular Valve Morphogenesis
Mitral Valve Morphogenesis
Tricuspid Valve Morphogenesis
Endocardial Cushion Development
Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cell Population Proliferation
Cellular Response To Starvation
Tissue Development
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial Cell Migration
Regulation Of Lung Blood Pressure
Cell Differentiation
Proteoglycan Biosynthetic Process
Negative Regulation Of Cell Growth
Lung Development
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Locomotion
Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Ossification
Negative Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Lung Alveolus Development
Negative Regulation Of Smooth Muscle Cell Proliferation
Cardiac Muscle Tissue Development
Positive Regulation Of Axon Extension Involved In Axon Guidance
Stem Cell Differentiation
Negative Regulation Of Muscle Cell Differentiation
Retina Development In Camera-type Eye
Limb Development
Endochondral Bone Morphogenesis
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Atrial Septum Morphogenesis
Lung Vasculature Development
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Positive Regulation Of Cartilage Development
Retina Vasculature Development In Camera-type Eye
Pharyngeal Arch Artery Morphogenesis
Cellular Response To Growth Factor Stimulus
Cellular Response To BMP Stimulus
Endothelial Cell Apoptotic Process
Negative Regulation Of Chondrocyte Proliferation
Semi-lunar Valve Development
Regulation Of Multicellular Organismal Development
Pathways
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
Sema3A PAK dependent Axon repulsion
Sema3A PAK dependent Axon repulsion
Sema4D induced cell migration and growth-cone collapse
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
Signaling by BMP
Drugs
Dabrafenib
Fostamatinib
Dibotermin alfa
Fostamatinib
Diseases
GWAS
Pulse pressure (
30224653
)
Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) (
30573655
)
Youthful appearance (self-reported) (
32339537
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Intelligence (MTAG) (
29326435
)
Mean corpuscular hemoglobin (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
PR interval (
32439900
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32154731
32203549
)
Urate levels (
23263486
)
Interacting Genes
31 interacting genes:
ABCA1
APP
ARRB1
ARRB2
BMPR2
CDC42BPA
CDKN1C
CFL1
CFL2
DSCAM
FBXO7
H1-1
HUNK
LATS1
LIMK2
MAPK14
MAPKAPK2
MBP
MFHAS1
NRG1
PAK1
PAK2
PAK4
PAK6
PXN
RLIM
ROCK1
SRPK1
SSH3
WASHC1
YWHAZ
53 interacting genes:
ACTR8
ACVR1
ACVR1B
ARSA
BMP10
BMP2
BMP4
BMP6
BMP7
BMPR1A
BMPR1B
C4BPA
CCDC89
CES1
CRIPTO
CRYAB
CTBP1
DYNLT1
FHL2
FOXL1
FRS3
GDF2
GDF5
GDF6
GDF9
HNRNPR
INHBA
INHBB
LIMK1
LMX1A
LSM10
LSP1
MAP3K8
MAPK8
MERTK
MOS
NBEA
NOP56
PDZRN3
PMPCA
PPP1CC
PRKCB
RABGGTA
SMURF1
SULT1E1
TGFBR1
TOPBP1
TRIB3
TRPC1
TSR1
TUBB
TUBB4A
TWF1
Entrez ID
3984
659
HPRD ID
03210
02880
Ensembl ID
ENSG00000106683
ENSG00000204217
Uniprot IDs
P53667
Q13873
PDB IDs
3S95
5HVJ
5HVK
5L6W
5NXC
6WLY
7ATS
7ATU
7B8W
8AAU
2HLQ
3G2F
6UNP
7PPA
7PPB
7PPC
7U5O
Enriched GO Terms of Interacting Partners
?
Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Positive Regulation Of Cellular Component Organization
Protein Kinase Activity
Regulation Of Cellular Component Organization
Kinase Activity
Intracellular Signal Transduction
Regulation Of Actin Filament Organization
Regulation Of Supramolecular Fiber Organization
Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Process
Regulation Of Actin Filament-based Process
Regulation Of Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
ATP Binding
Positive Regulation Of Multicellular Organismal Process
Regulation Of Developmental Growth
Nucleotide Binding
Actin Cytoskeleton Organization
Regulation Of Interleukin-6 Production
Regulation Of Protein Localization To Nucleus
Regulation Of Cytoskeleton Organization
Actin Filament-based Process
Cellular Response To Starvation
Transferase Activity
Regulation Of Growth
Response To Growth Factor
Negative Regulation Of Protein Localization To Nucleus
Regulation Of Developmental Process
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Response To Nutrient Levels
Dendritic Spine Development
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Cell Projection Organization
Angiotensin Receptor Binding
Protein Phosphorylation
Regulation Of Receptor-mediated Endocytosis
Response To Starvation
Positive Regulation Of Cellular Component Biogenesis
Phosphorylation
Positive Regulation Of Growth
Regulation Of Immune Response
Regulation Of Organelle Organization
Cellular Response To Nutrient Levels
Regulation Of Phosphorus Metabolic Process
Clathrin-coated Pit
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of SMAD Protein Signal Transduction
Regulation Of SMAD Protein Signal Transduction
Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cellular Response To BMP Stimulus
Positive Regulation Of Cartilage Development
Growth Factor Activity
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Cartilage Development
Osteoblast Differentiation
Positive Regulation Of Cell Differentiation
Positive Regulation Of Bone Mineralization
Regulation Of Multicellular Organismal Development
Heart Development
Cytokine Activity
Cellular Response To Growth Factor Stimulus
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Positive Regulation Of Biomineral Tissue Development
Positive Regulation Of Multicellular Organismal Process
Cell Surface Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Activity, Type I
Positive Regulation Of Ossification
Regulation Of Cell Differentiation
Response To Growth Factor
Positive Regulation Of Developmental Process
Cartilage Development
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Positive Regulation Of Osteoblast Differentiation
Regulation Of Developmental Process
Positive Regulation Of Signal Transduction
Regulation Of Ossification
Regulation Of Bone Mineralization
SMAD Binding
Cell Differentiation
Regulation Of Chondrocyte Differentiation
Animal Organ Development
Enzyme Activator Complex
Regulation Of Osteoblast Differentiation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Endocardial Cushion Formation
BMP Receptor Binding
Cellular Developmental Process
Regulation Of Growth
Protein Kinase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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