LIMK1 and LIMK2

Number of citations of the paper that reports this interaction (PubMedID 8980133)
0

Data Source:
HPRD (in vitro, in vivo)

		LIMK1	LIMK2
Description		LIM domain kinase 1	LIM domain kinase 2
Image
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Cell Junction Cell Projection Neuron Projection Postsynapse Glutamatergic Synapse	Nucleus Cytoplasm Cis-Golgi Network Centrosome Spindle Cytoskeleton Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin Ligase Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stress Fiber Assembly Positive Regulation Of Axon Extension Axon Extension Positive Regulation Of Stress Fiber Assembly	Protein Phosphorylation Spermatogenesis Actin Cytoskeleton Organization Astral Microtubule Organization Establishment Of Vesicle Localization Head Development Cornea Development In Camera-type Eye Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs	EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs
Drugs		Dabrafenib Fostamatinib	Fostamatinib
Diseases
GWAS		Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)	Eosinophil count ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Fish- and plant-related diet ( 32066663) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Oily fish consumption ( 32066663) Paclitaxel-induced neuropathy ( 23776197) Pork consumption ( 32066663) Red cell distribution width ( 32888494) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		31 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 DSCAM FBXO7 H1-1 HUNK LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ	12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1
Entrez ID		3984	3985
HPRD ID		03210	03585
Ensembl ID		ENSG00000106683	ENSG00000182541
Uniprot IDs		P53667	P53671
PDB IDs		3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU 7B8W 8AAU	1X6A 4TPT 5NXD 7QHG 8GI4 8S3X 8WSW
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Protein Kinase Activity Regulation Of Cellular Component Organization Kinase Activity Intracellular Signal Transduction Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling ATP Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Nucleotide Binding Actin Cytoskeleton Organization Regulation Of Interleukin-6 Production Regulation Of Protein Localization To Nucleus Regulation Of Cytoskeleton Organization Actin Filament-based Process Cellular Response To Starvation Transferase Activity Regulation Of Growth Response To Growth Factor Negative Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Nutrient Levels Dendritic Spine Development Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Projection Organization Angiotensin Receptor Binding Protein Phosphorylation Regulation Of Receptor-mediated Endocytosis Response To Starvation Positive Regulation Of Cellular Component Biogenesis Phosphorylation Positive Regulation Of Growth Regulation Of Immune Response Regulation Of Organelle Organization Cellular Response To Nutrient Levels Regulation Of Phosphorus Metabolic Process Clathrin-coated Pit	Lamellipodium Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Cytoskeleton Organization Protein Serine Kinase Activity Protein Phosphorylation Internode Region Of Axon Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Cellular Component Organization Rho Protein Signal Transduction Protein Kinase Activity Actin Filament Depolymerization Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Actin Filament Severing Regulation Of Multicellular Organismal Process Myelination Axon Ensheathment Kinase Activity Actomyosin Structure Organization Positive Regulation Of Multicellular Organismal Process Myelination In Peripheral Nervous System Positive Regulation Of Cellular Component Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Cytosol Organelle Organization Regulation Of Proteolysis Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Immune System Process Muscle Cell Migration Positive Regulation Of Cell Growth Positive Regulation Of Focal Adhesion Assembly Regulation Of Cell Development Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Apoptotic Process Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Positive Regulation Of Cytoskeleton Organization Regulation Of Multicellular Organismal Development Protein Depolymerization Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death
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