LIMK1 and CFL2

Number of citations of the paper that reports this interaction (PMID 9655398)
225

Data Source:
HPRD (in vivo, in vitro)

		LIMK1	CFL2
Gene Name		LIM domain kinase 1	cofilin 2 (muscle)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Focal Adhesion Neuron Projection	Extracellular Space Actin Cytoskeleton Nuclear Matrix I Band Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Heat Shock Protein Binding Protein Heterodimerization Activity	Actin Binding Protein Binding
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Axon Guidance Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Positive Regulation Of Axon Extension Ephrin Receptor Signaling Pathway Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly	Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Regulation Of Dendritic Spine Morphogenesis
Pathways		EPHB-mediated forward signaling Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema3A PAK dependent Axon repulsion Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 HIST1H1A LATS1 LIMK2 MAPK14 MAPKAPK2 MBP NRG1 PAK1 PAK2 PAK4 PXN RLIM ROCK1 SRPK1 SSH3 YWHAZ	8 interactors: ACTB ACTG1 CAP2 CFL1 DSTN LIMK1 POT1 SSH1
Entrez ID		3984	1073
HPRD ID		03210	03262
Ensembl ID		ENSG00000106683	ENSG00000165410
Uniprot IDs		P53667	Q549N0 Q9Y281
PDB IDs		3S95
Enriched GO Terms of Interacting Partners?		Phosphorylation Cellular Protein Modification Process Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Signal Transduction By Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Protein Metabolic Process Platelet Activation Signaling Regulation Of Kinase Activity Cell Communication Response To External Stimulus Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Cellular Amino Acid Metabolic Process Signal Transduction Cell Differentiation Generation Of Neurons Regulation Of Cellular Protein Metabolic Process Response To Stress Regulation Of Organelle Organization Locomotion Immune Response Neurogenesis Apoptotic Process Response To Wounding Positive Regulation Of Cellular Metabolic Process Anatomical Structure Development Regulation Of Signaling Defense Response Programmed Cell Death Organelle Organization Immune System Process Regulation Of Protein Metabolic Process	Ephrin Receptor Signaling Pathway Axon Guidance Organelle Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cell Morphogenesis Axonogenesis Cytoskeleton Organization Axon Development Cell Morphogenesis Involved In Neuron Differentiation Actin Cytoskeleton Organization Chemotaxis Actin Filament-based Process Neuron Projection Morphogenesis Phagocytosis Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Immune Response-activating Cell Surface Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Generation Of Neurons Positive Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Neuron Projection Development Cell Projection Morphogenesis Neurogenesis Cell Part Morphogenesis Regulation Of Actin Cytoskeleton Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Neuron Development Positive Regulation Of Protein Depolymerization Actin Filament Depolymerization Immune Response-regulating Signaling Pathway Neuron Differentiation Regulation Of Cytoskeleton Organization Cell Projection Organization Nervous System Development Locomotion Anatomical Structure Morphogenesis Positive Regulation Of Protein Complex Disassembly Platelet Activation Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Positive Regulation Of Immune Response Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Tagcloud ?		alkaloid cdk4 changing chemoresistance cofilin cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845	adipogenesis adipogenic adipose ankrd1 ankyrin bovine bulls cofilin dehydrogenase differentially hspb1 lactate ldhb likewise mlc1 monitored myogenesis myogenic myosin repeat skeletal steers taldo1 tenfold testosterone threefold transaldolase twofold vary
Tagcloud (Difference) ?		alkaloid cdk4 changing chemoresistance cytotoxic decreasing detecting egfr egfrp erk1 explored extracted flavescens gastric herb invasion matrine mek mmp2 oxide oxymatrine phospho quinolizidine root ser3 sophora thr508 tyr845	adipogenesis adipogenic adipose ankrd1 ankyrin bovine bulls dehydrogenase differentially hspb1 lactate ldhb likewise mlc1 monitored myogenesis myogenic myosin repeat skeletal steers taldo1 tenfold testosterone threefold transaldolase twofold vary
Tagcloud (Intersection) ?		cofilin