LIMK1 and ABCA1

Number of citations of the paper that reports this interaction (PubMedID 16192283)
60

Data Source:
HPRD (in vitro)

		LIMK1	ABCA1
Description		LIM domain kinase 1	ATP binding cassette subfamily A member 1
Image
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Cell Junction Cell Projection Neuron Projection Postsynapse Glutamatergic Synapse	Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Endocytic Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Intracellular Vesicle
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin Ligase Inhibitor Activity	Nucleotide Binding Signaling Receptor Binding Protein Binding ATP Binding Phospholipid Transporter Activity High-density Lipoprotein Particle Binding Protein Transmembrane Transporter Activity Cholesterol Binding ATP Hydrolysis Activity Syntaxin Binding Phosphatidylcholine Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase-coupled Transmembrane Transporter Activity Sphingolipid Floppase Activity ATPase Binding Phosphatidylcholine Floppase Activity Phosphatidylserine Floppase Activity Cholesterol Transfer Activity ATPase-coupled Intramembrane Lipid Transporter Activity Floppase Activity ABC-type Transporter Activity
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stress Fiber Assembly Positive Regulation Of Axon Extension Axon Extension Positive Regulation Of Stress Fiber Assembly	Peptide Secretion Lipid Metabolic Process Phagocytosis, Engulfment Lysosome Organization G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Response To Nutrient Steroid Metabolic Process Cholesterol Metabolic Process Protein Secretion Response To Xenobiotic Stimulus Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Organic Hydroxy Compound Transport Phospholipid Transport Endosomal Transport Signal Release Cholesterol Transport Response To Nutrient Levels Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Response To Vitamin B3 Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Cholesterol Homeostasis Reverse Cholesterol Transport Phospholipid Translocation Establishment Of Localization In Cell Transmembrane Transport Phospholipid Homeostasis Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cytokine Stimulus Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Xenobiotic Stimulus Protein Transmembrane Transport Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of High-density Lipoprotein Particle Assembly Sphingolipid Translocation Export Across Plasma Membrane
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs	PPARA activates gene expression Defective ABCA1 causes TGD HDL assembly NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs		Dabrafenib Fostamatinib	ATP Glyburide Probucol
Diseases			Tangier disease Hypoalphalipoproteinemia
GWAS		Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)	A body shape index ( 34021172) Advanced age-related macular degeneration ( 26691988) Allergic rhinitis ( 25085501) Aluminium levels ( 26025379) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Cardiometabolic and hematological traits ( 27668658) Cholesterol, total ( 20686565 24097068 25961943 26582766) Coronary artery disease ( 29212778 33020668) Glaucoma ( 30054594 31959993) Glaucoma (high intraocular pressure) ( 25173107) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 25173105 29452408 29891935 33627673) Gout ( 22179738) HDL cholesterol ( 18193043 18193044 19060906 19060911 20686565 20864672 21347282 21909109 23505323 24097068 25961943 26160806 26582766 26780889 28270201 30275531) HDL cholesterol levels ( 26690388 28334899 30698716 31087446 31694877 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29403010 29615537 30718733 33339817) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 25173106 28073927 29235454 29617998 29785010 30054594 30591961 31798171 31959993) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 30275531) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Low high density lipoprotein cholesterol levels ( 26879886) Lung cancer in ever smokers ( 28604730) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 31589552) Metabolite levels ( 22916037 31628463) Myopia (pathological) ( 23049088) Pelvic organ prolapse ( 26545240) Periodontitis (Mean PAL) ( 24024966) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to fenofibrate (total cholesterol levels) ( 27002377) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systemic mastocytosis ( 32752121) Total cholesterol levels ( 28334899 29403010 30275531 31087446 33339817) Triglyceride levels ( 32154731 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Whole-brain volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		31 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 DSCAM FBXO7 H1-1 HUNK LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ	41 interacting genes: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBIN FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ PALS2 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2
Entrez ID		3984	19
HPRD ID		03210	02501
Ensembl ID		ENSG00000106683	ENSG00000165029
Uniprot IDs		P53667	B2RUU2 B7XCW9 O95477
PDB IDs		3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU 7B8W 8AAU	5XJY 7ROQ 7TBW 7TBY 7TBZ 7TC0 7TDT
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Protein Kinase Activity Regulation Of Cellular Component Organization Kinase Activity Intracellular Signal Transduction Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling ATP Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Nucleotide Binding Actin Cytoskeleton Organization Regulation Of Interleukin-6 Production Regulation Of Protein Localization To Nucleus Regulation Of Cytoskeleton Organization Actin Filament-based Process Cellular Response To Starvation Transferase Activity Regulation Of Growth Response To Growth Factor Negative Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Nutrient Levels Dendritic Spine Development Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Projection Organization Angiotensin Receptor Binding Protein Phosphorylation Regulation Of Receptor-mediated Endocytosis Response To Starvation Positive Regulation Of Cellular Component Biogenesis Phosphorylation Positive Regulation Of Growth Regulation Of Immune Response Regulation Of Organelle Organization Cellular Response To Nutrient Levels Regulation Of Phosphorus Metabolic Process Clathrin-coated Pit	Anchoring Junction MPP7-DLG1-LIN7 Complex Synapse Plasma Membrane Neuromuscular Junction PDZ Domain Binding Regulation Of Synaptic Assembly At Neuromuscular Junction Neurotransmitter Secretion Postsynaptic Density Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Dystrophin-associated Glycoprotein Complex Cell-cell Junction Intracellular Protein Localization Bicellular Tight Junction Protein Kinase CK2 Complex L27 Domain Binding Protein-containing Complex Organization Basolateral Plasma Membrane Cellular Component Assembly Protein-containing Complex Assembly Establishment Or Maintenance Of Cell Polarity Signal Release Protein Localization To Cell Junction Ionotropic Glutamate Receptor Binding Synaptic Vesicle Transport Adherens Junction Neurotransmitter Transport Regulation Of Macroautophagy Establishment Of Vesicle Localization Neuron Projection Vesicle Localization Membrane High-density Lipoprotein Particle Assembly Postsynaptic Membrane Regulation Of Autophagy High-density Lipoprotein Particle Binding Cytoplasm Protein Localization To Synapse Postsynaptic Density Glutamatergic Synapse Regulation Of Monoatomic Anion Transport Small GTPase-mediated Signal Transduction Regulation Of Cell Junction Assembly Rho Protein Signal Transduction Muscle Alpha-actinin Binding Apical Protein Localization Regulation Of Cellular Component Organization Regulation Of Growth Cytoskeletal Protein Binding
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