LIMK1 and PAK4

Number of citations of the paper that reports this interaction (PubMedID 11413130)
0

Data Source:
HPRD (in vitro)

		LIMK1	PAK4
Description		LIM domain kinase 1	p21 (RAC1) activated kinase 4
Image
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Cell Junction Cell Projection Neuron Projection Postsynapse Glutamatergic Synapse	Cytoplasm Golgi Apparatus Cytosol Adherens Junction Focal Adhesion
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Protein Serine Kinase Activity Ubiquitin Ligase Inhibitor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein-macromolecule Adaptor Activity Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stress Fiber Assembly Positive Regulation Of Axon Extension Axon Extension Positive Regulation Of Stress Fiber Assembly	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Cellular Response To Starvation Cell Migration Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Protein Stabilization Dendritic Spine Development Cell-cell Adhesion Positive Regulation Of Focal Adhesion Disassembly Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle
Drugs		Dabrafenib Fostamatinib	Fostamatinib
Diseases
GWAS		Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		31 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 DSCAM FBXO7 H1-1 HUNK LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SRPK1 SSH3 WASHC1 YWHAZ	23 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAZ
Entrez ID		3984	10298
HPRD ID		03210	05675
Ensembl ID		ENSG00000106683	ENSG00000130669
Uniprot IDs		P53667	O96013
PDB IDs		3S95 5HVJ 5HVK 5L6W 5NXC 6WLY 7ATS 7ATU 7B8W 8AAU	2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY 7CMB 7CP3 7CP4 7S46 7S47 7S48 8AHG 8AHH 8AHI 8YHK
Enriched GO Terms of Interacting Partners?		Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Positive Regulation Of Cellular Component Organization Protein Kinase Activity Regulation Of Cellular Component Organization Kinase Activity Intracellular Signal Transduction Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Multicellular Organismal Process Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling ATP Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Nucleotide Binding Actin Cytoskeleton Organization Regulation Of Interleukin-6 Production Regulation Of Protein Localization To Nucleus Regulation Of Cytoskeleton Organization Actin Filament-based Process Cellular Response To Starvation Transferase Activity Regulation Of Growth Response To Growth Factor Negative Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Response To Nutrient Levels Dendritic Spine Development Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Cell Projection Organization Angiotensin Receptor Binding Protein Phosphorylation Regulation Of Receptor-mediated Endocytosis Response To Starvation Positive Regulation Of Cellular Component Biogenesis Phosphorylation Positive Regulation Of Growth Regulation Of Immune Response Regulation Of Organelle Organization Cellular Response To Nutrient Levels Regulation Of Phosphorus Metabolic Process Clathrin-coated Pit	Focal Adhesion Integrin Alphav-beta5 Complex Intracellular Signal Transduction Actin Cytoskeleton Organization Intracellular Signaling Cassette Actin Filament-based Process Endodermal Cell Differentiation Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Shelterin Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Establishment Of Golgi Localization Positive Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Positive Regulation Of Supramolecular Fiber Organization Nucleus Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Branching Involved In Labyrinthine Layer Morphogenesis Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Protein Phosphorylation Telomeric Loop Disassembly Regulation Of Protein Localization Receptor Complex Regulation Of Intracellular Signal Transduction Phosphorylation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Telomere Capping Golgi Localization Innate Immune Response Organelle Organization Negative Regulation Of Immune Response Wound Healing, Spreading Of Epidermal Cells Negative Regulation Of Macromolecule Metabolic Process Phagocytic Vesicle Protein Domain Specific Binding Chromosome Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Endocytosis Identical Protein Binding Phosphate-containing Compound Metabolic Process Negative Regulation Of Innate Immune Response Integrin-mediated Signaling Pathway Defense Response To Symbiont Negative Regulation Of Telomere Maintenance Via Telomerase Actin Filament Organization Small GTPase-mediated Signal Transduction Fibroblast Growth Factor Binding Negative Regulation Of Lipid Storage
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