EIF4A1 and PDCD4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, affinity chromatography technology)

		EIF4A1	PDCD4
Description		eukaryotic translation initiation factor 4A1	programmed cell death 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Nuclear Stress Granule	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Cap Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Hydrolase Activity ATP Hydrolysis Activity	RNA Binding Protein Binding
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Transcription By RNA Polymerase II	Apoptotic Process BMP Signaling Pathway Negative Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Fish- and plant-related diet ( 32066663)
Interacting Genes		19 interacting genes: CEBPA EIF4G1 EIF4G2 EIF4G3 FAM107A FTCD LIG4 MAPK6 OGT PAIP1 PDCD4 PLPPR4 PRMT5 RIPPLY3 SUMO2 TNKS UCHL5 UPF2 WDR77	21 interacting genes: APOE BTRC CSNK2A1 EIF4A1 EIF4A2 EIF4A3 EIF4G1 FILNC1 IBTK LRRK1 OGT PRMT5 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2 WDR77
Entrez ID		1973	27250
HPRD ID		04030	10549
Ensembl ID		ENSG00000161960	ENSG00000150593
Uniprot IDs		P60842	B4DKX4 Q53EL6
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW 7PPZ 7PQ0 8HUJ 8OZ0 8XXN 9AVR 9BLN 9DTS	2GGF 2KZT 2RG8 2ZU6 3EIJ 8XXL 8XXM 8XXN 9BKD 9BLN
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Translational Initiation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Translation Initiation Factor Activity Positive Regulation Of Translation Animal Organ Regeneration Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Translation Methylosome Lateral Ventricle Development Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Process Response To Lithium Ion RNA Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Liver Development Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Cytosol Methyl-CpG Binding Regeneration Positive Regulation Of MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Nucleus Translation Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Developmental Process	Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Translation Regulation Of Primary Metabolic Process Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Translation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Amyloid Precursor Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Translational Initiation Cytoplasmic Translational Initiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Translation Ribonucleoprotein Complex Binding Negative Regulation Of Macromolecule Metabolic Process Aspartic Endopeptidase Activity, Intramembrane Cleaving Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Proteolysis Translation Initiation Factor Activity Gamma-secretase Complex Negative Regulation Of Metabolic Process Positive Regulation Of Translation Regulation Of Wnt Signaling Pathway Negative Regulation Of Gene Expression Notch Receptor Processing Glutamatergic Synapse Amyloid-beta Formation Epithelial Cell Proliferation TORC1 Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction
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