EIF4A1 and MYH10

		EIF4A1	MYH10
Description		eukaryotic translation initiation factor 4A1	myosin heavy chain 10
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Nuclear Stress Granule	Stress Fiber Nucleus Cytoplasm Spindle Cytosol Plasma Membrane Brush Border Cell Cortex Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Myosin Complex Myosin II Complex Sarcoplasm Lamellipodium Axon Growth Cone Midbody Neuromuscular Junction Cleavage Furrow Myosin Filament Actomyosin Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Extracellular Exosome Myosin II Filament Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Supramolecular Fiber
	Molecular Function	Nucleotide Binding RNA Cap Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Hydrolase Activity ATP Hydrolysis Activity	Microfilament Motor Activity Nucleotide Binding Virus Receptor Activity Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding RNA Stem-loop Binding ADP Binding MRNA 5'-UTR Binding Actin Filament Binding
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Transcription By RNA Polymerase II	Mitotic Cytokinesis In Utero Embryonic Development Neuron Migration Plasma Membrane Repair Cardiac Septum Development Exocytosis Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Cell Adhesion Axonogenesis Axon Guidance Brain Development Heart Development Adult Heart Development Regulation Of Cell Shape Fourth Ventricle Development Lateral Ventricle Development Third Ventricle Development Cerebellar Purkinje Cell Layer Development Actin Cytoskeleton Organization Actin Filament-based Movement Myofibril Assembly Actomyosin Structure Organization Neuron Projection Development Aorta Development Symbiont Entry Into Host Cell Positive Regulation Of Protein Secretion Neuromuscular Process Controlling Balance Cardiac Myofibril Assembly Ventricular Cardiac Muscle Cell Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Coronary Vasculature Development Postsynaptic Actin Cytoskeleton Organization
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Type 2 diabetes ( 30130595)
Interacting Genes		19 interacting genes: CEBPA EIF4G1 EIF4G2 EIF4G3 FAM107A FTCD LIG4 MAPK6 OGT PAIP1 PDCD4 PLPPR4 PRMT5 RIPPLY3 SUMO2 TNKS UCHL5 UPF2 WDR77	14 interacting genes: ANXA1 APC BCAP31 DUX4 ECPAS FXR1 FXR2 MYH9 PBX1 PTEN S100A4 YWHAE YWHAG ZNF512B
Entrez ID		1973	4628
HPRD ID		04030	01178
Ensembl ID		ENSG00000161960	ENSG00000133026
Uniprot IDs		P60842	A0A8I5KZ38 G1UI33 P35580
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW 7PPZ 7PQ0 8HUJ 8OZ0 8XXN 9AVR 9BLN 9DTS	4PD3
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Translational Initiation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Translation Initiation Factor Activity Positive Regulation Of Translation Animal Organ Regeneration Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Translation Methylosome Lateral Ventricle Development Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Process Response To Lithium Ion RNA Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Liver Development Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Cytosol Methyl-CpG Binding Regeneration Positive Regulation Of MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Nucleus Translation Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Developmental Process	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Protein Targeting Dentate Gyrus Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Primary Metabolic Process Lateral Plasma Membrane Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Cytoplasmic Stress Granule Protein Localization To Endoplasmic Reticulum Cytoplasm Translation Regulator Activity Regulation Of Macromolecule Biosynthetic Process RNA Binding Regulation Of Cell Differentiation Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein Phosphorylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Meiotic Spindle Organization Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Plasma Membrane Bounded Cell Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Mononuclear Cell Differentiation Regulation Of Wound Healing Regulation Of Mitotic Cell Cycle Phase Transition Molecular Function Inhibitor Activity Negative Regulation Of Metabolic Process Cytoplasmic Translational Initiation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microfilament Motor Activity Positive Regulation Of Translation Regulation Of G1/S Transition Of Mitotic Cell Cycle
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