EIF4A1 and TNKS

Number of citations of the paper that reports this interaction (PubMedID 29604130)
45

Data Source:
BioGRID (pull down)

		EIF4A1	TNKS
Description		eukaryotic translation initiation factor 4A1	tankyrase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Nuclear Stress Granule	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Spindle Pole Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Membrane Nuclear Body Nuclear Membrane Mitotic Spindle Pole
	Molecular Function	Nucleotide Binding RNA Cap Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Hydrolase Activity ATP Hydrolysis Activity	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Telomerase Inhibitor Activity Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Histone Binding Metal Ion Binding NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Transcription By RNA Polymerase II	Protein Polyubiquitination Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	A body shape index ( 34021172) Acne (severe) ( 24927181) Age at first birth ( 34211149) Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) LDL cholesterol levels ( 32203549) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32154731) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		19 interacting genes: CEBPA EIF4G1 EIF4G2 EIF4G3 FAM107A FTCD LIG4 MAPK6 OGT PAIP1 PDCD4 PLPPR4 PRMT5 RIPPLY3 SUMO2 TNKS UCHL5 UPF2 WDR77	34 interacting genes: ADPRS ANKRD28 AXIN1 CACNA1S CDKN1A DTNBP1 EIF4A1 ENDOG EPM2AIP1 FANCD2 FNBP1 GMDS HNRNPM INPP5K LNPEP MAVS MCL1 NELFE NUMA1 OARD1 PLCH2 POT1 PTEN RNF146 RUNDC1 SDCBP TCL1A TERF1 TNIK TNKS1BP1 TNKS2 UBASH3B USP25 VPS33A
Entrez ID		1973	8658
HPRD ID		04030	04490
Ensembl ID		ENSG00000161960	ENSG00000173273
Uniprot IDs		P60842	H0YAW5 O95271
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW 7PPZ 7PQ0 8HUJ 8OZ0 8XXN 9AVR 9BLN 9DTS	2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU 6URQ 7KKM 7KKN 7KKO 7KKP 7KKQ 7OCV 8X5J
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Translational Initiation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Translation Initiation Factor Activity Positive Regulation Of Translation Animal Organ Regeneration Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Translation Methylosome Lateral Ventricle Development Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Process Response To Lithium Ion RNA Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Liver Development Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Cytosol Methyl-CpG Binding Regeneration Positive Regulation Of MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Nucleus Translation Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Developmental Process	Nucleus Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Protein Serine/threonine Kinase Binding Telomere Maintenance Via Telomere Lengthening RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomere Lengthening O-acetyl-ADP-ribose Deacetylase Activity Positive Regulation Of Cellular Component Organization Chromosome Positive Regulation Of Chromosome Organization Negative Regulation Of Telomere Maintenance Shelterin Complex Protein De-ADP-ribosylation Regulation Of Signal Transduction Ankyrin Repeat Binding Regulation Of Telomere Maintenance Via Telomerase In Utero Embryonic Development Organelle Organization Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Component Organization Embryo Development Ending In Birth Or Egg Hatching Chordate Embryonic Development Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Multicellular Organism Development Positive Regulation Of DNA Metabolic Process Protein Polyubiquitination Telomeric Loop Disassembly Telomere Capping Perinuclear Region Of Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Cytoplasm Positive Regulation Of Organelle Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Chromosome Organization Macromolecule Metabolic Process Nuclear Body DNA Damage Response Hydrolase Activity Cellular Response To Oxidative Stress
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