EIF4A1

Description		eukaryotic translation initiation factor 4A1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Stress Granule Membrane Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Nuclear Stress Granule
	Molecular Function	Nucleotide Binding RNA Cap Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding MRNA Binding Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding Translation Factor Activity, RNA Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs		Copper
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)
Novel Interacting Genes		1 novel interacting genes: MYH10
Interacting Genes		19 interacting genes: CEBPA EIF4G1 EIF4G2 EIF4G3 FAM107A FTCD LIG4 MAPK6 OGT PAIP1 PDCD4 PLPPR4 PRMT5 RIPPLY3 SUMO2 TNKS UCHL5 UPF2 WDR77
Entrez ID		1973
HPRD ID		04030
Ensembl ID		ENSG00000161960
Uniprot IDs		P60842
PDB IDs		2G9N 2ZU6 3EIQ 5ZBZ 5ZC9 6ZMW 7PPZ 7PQ0 8HUJ 8OZ0 8XXN 9AVR 9BLN 9DTS
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Metabolic Process Translation Factor Activity, RNA Binding Translational Initiation Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Translation Initiation Factor Activity Positive Regulation Of Translation Animal Organ Regeneration Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Translation Methylosome Lateral Ventricle Development Regulation Of Macromolecule Biosynthetic Process Cellular Response To Lithium Ion Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Process Response To Lithium Ion RNA Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Liver Development Negative Regulation Of Autophagy Positive Regulation Of Chromosome Organization Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Cytosol Methyl-CpG Binding Regeneration Positive Regulation Of MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Metabolic Process Nucleus Translation Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Macromolecule Biosynthetic Process Regulation Of Proteolysis RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Developmental Process
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