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CTSK
Gene Name
cathepsin K
Image
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endolysosome Lumen
Molecular Function
Fibronectin Binding
Cysteine-type Endopeptidase Activity
Collagen Binding
Cysteine-type Peptidase Activity
Proteoglycan Binding
Biological Process
Intramembranous Ossification
Toll-like Receptor Signaling Pathway
Proteolysis
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Collagen Catabolic Process
Innate Immune Response
Bone Resorption
Proteolysis Involved In Cellular Protein Catabolic Process
Pathways
Toll-Like Receptors Cascades
Trafficking and processing of endosomal TLR
Collagen degradation
Activation of Matrix Metalloproteinases
MHC class II antigen presentation
Degradation of the extracellular matrix
Adaptive Immune System
Innate Immune System
Drugs
Diseases
GWAS
Melanoma (
21983785
)
Rhegmatogenous retinal detachment (
23585552
)
Protein-protein Interactions
6 interactors:
FGFR3
KNG1
LIG4
SERPINB13
SERPINB3
SPARC
Entrez ID
1513
HPRD ID
03064
Ensembl ID
ENSG00000143387
Uniprot IDs
P43235
PDB IDs
1ATK
1AU0
1AU2
1AU3
1AU4
1AYU
1AYV
1AYW
1BGO
1BY8
1MEM
1NL6
1NLJ
1Q6K
1SNK
1TU6
1U9V
1U9W
1U9X
1VSN
1YK7
1YK8
1YT7
2ATO
2AUX
2AUZ
2BDL
2R6N
3C9E
3H7D
3KW9
3KWB
3KWZ
3KX1
3O0U
3O1G
3OVZ
4DMX
4DMY
7PCK
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Peptidase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Protein Processing
Regulation Of Endopeptidase Activity
Negative Regulation Of Hydrolase Activity
Regulation Of Protein Processing
Regulation Of Peptidase Activity
Somatic Stem Cell Maintenance
Platelet Degranulation
Regulation Of Endothelial Cell Proliferation
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
DNA Ligation Involved In DNA Recombination
Regulation Of Proteolysis
Negative Regulation Of Epithelial Cell Proliferation
Cell Activation
Response To Wounding
Stem Cell Maintenance
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Catalytic Activity
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Inner Ear Development
Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Metabolic Process
Platelet Activation
Regulation Of Catalytic Activity
Bone Development
Ear Development
Lagging Strand Elongation
Pro-B Cell Differentiation
Alveolar Secondary Septum Development
Regulation Of Neuron Apoptotic Process
Lung Development
Axonogenesis Involved In Innervation
Stem Cell Development
Respiratory Tube Development
Response To Abiotic Stimulus
Response To Stimulus
Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Establishment Of Integrated Proviral Latency
Ossification
Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
Respiratory System Development
Regulation Of Epithelial Cell Proliferation
Regulation Of Neuron Death
Immunoglobulin V(D)J Recombination
Chondrocyte Proliferation
Response To L-ascorbic Acid
Establishment Of Viral Latency
Tagcloud
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alkaline
alp
ccd
cleidocranial
cocultured
ctr
dental
dspp
dysplasia
heterozygous
interfered
mineralization
mineralized
mmp9
mononuclear
nodules
ocn
odontoblast
opg
osteoblast
osteoclast
partly
pulp
rankl
remodeling
retention
runx2
teeth
tooth