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CTSK and LIG4
Number of citations of the paper that reports this interaction (PubMedID
22990118
)
93
Data Source:
BioGRID
(two hybrid)
CTSK
LIG4
Description
cathepsin K
DNA ligase 4
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleoplasm
Lysosome
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Apical Plasma Membrane
Endolysosome Lumen
Lysosomal Lumen
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Nonhomologous End Joining Complex
Molecular Function
Fibronectin Binding
Cysteine-type Endopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Collagen Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
Proteoglycan Binding
Nucleotide Binding
Magnesium Ion Binding
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
AMP Binding
Ligase Activity
Metal Ion Binding
Biological Process
Mitophagy
Proteolysis
Thyroid Hormone Generation
Extracellular Matrix Disassembly
Collagen Catabolic Process
Bone Resorption
Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of Cartilage Development
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Repair
Base-excision Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
DNA Damage Response
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Ionizing Radiation
Response To Gamma Radiation
Neurogenesis
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Fibroblast Proliferation
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Stem Cell Proliferation
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
DN2 Thymocyte Differentiation
Positive Regulation Of Chromosome Organization
Pathways
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Trafficking and processing of endosomal TLR
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
Drugs
[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate
Cyanamide
3-amino-5-phenylpentane
N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide
N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide
N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamide
Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamate
N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide
(2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamide
Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate
MIV-701
Relacatib
Odanacatib
1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine
(2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamate
1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE
6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile
9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE
N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE
(1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide
TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE
Balicatib
MIV-711
Diseases
Pycnodysostosis
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Aspartate aminotransferase levels (
33547301
)
Body mass index (
26426971
)
Congenital left-sided heart lesions (
26965164
)
Melanoma (
21983785
)
Rhegmatogenous retinal detachment (
23585552
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Interacting Genes
6 interacting genes:
FGFR3
KNG1
LIG4
SERPINB13
SERPINB3
SPARC
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATOSA
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
Entrez ID
1513
3981
HPRD ID
03064
03500
Ensembl ID
ENSG00000143387
ENSG00000174405
Uniprot IDs
P43235
A0A0C4DGV9
A8K8Q4
P49917
PDB IDs
1ATK
1AU0
1AU2
1AU3
1AU4
1AYU
1AYV
1AYW
1BGO
1BY8
1MEM
1NL6
1NLJ
1Q6K
1SNK
1TU6
1U9V
1U9W
1U9X
1VSN
1YK7
1YK8
1YT7
2ATO
2AUX
2AUZ
2BDL
2R6N
3C9E
3H7D
3KW9
3KWB
3KWZ
3KX1
3O0U
3O1G
3OVZ
4DMX
4DMY
4N79
4N8W
4X6H
4X6I
4X6J
4YV8
4YVA
5J94
5JA7
5JH3
5TDI
5TUN
5Z5O
6ASH
6HGY
6PXF
6QBS
6QL8
6QLM
6QLW
6QLX
6QM0
7NXL
7NXM
7PCK
7QBL
7QBM
7QBN
7QBO
8C3D
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
7D9K
7D9Y
7LSY
7LT3
7NFC
7NFE
8BH3
8BHV
8BHY
8BOT
8EZA
8EZB
Enriched GO Terms of Interacting Partners
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Cysteine-type Endopeptidase Inhibitor Activity
Peptidase Inhibitor Activity
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Proteolysis
Negative Regulation Of Peptidase Activity
Regulation Of Endopeptidase Activity
Negative Regulation Of Hydrolase Activity
Endopeptidase Inhibitor Activity
Platelet Alpha Granule Lumen
Regulation Of Proteolysis
Establishment Of Integrated Proviral Latency
Negative Regulation Of Keratinocyte Apoptotic Process
Serine-type Endopeptidase Inhibitor Activity
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Establishment Of Viral Latency
Protease Binding
Positive Regulation Of Hydrolase Activity
Positive Regulation Of Phospholipase Activity
Bone Maturation
Regulation Of Catalytic Activity
Extracellular Space
Negative Regulation Of Protein Metabolic Process
DNA Ligase (ATP) Activity
DNA Ligase IV Complex
Pro-B Cell Differentiation
T Cell Receptor V(D)J Recombination
DNA Ligase Activity
DN2 Thymocyte Differentiation
Regulation Of Protein Metabolic Process
Negative Regulation Of Catalytic Activity
Fibroblast Growth Factor Receptor Activity
Regulation Of Cell Population Proliferation
Nucleotide-excision Repair, DNA Gap Filling
Positive Regulation Of Lipase Activity
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Immunoglobulin V(D)J Recombination
Nonhomologous End Joining Complex
Regulation Of Keratinocyte Apoptotic Process
Autocrine Signaling
Negative Regulation Of JUN Kinase Activity
Paracrine Signaling
Positive Regulation Of Endopeptidase Activity
Semicircular Canal Morphogenesis
BBSome
Endochondral Bone Growth
Positive Regulation Of Cell Population Proliferation
Double-strand Break Repair Via Classical Nonhomologous End Joining
Single Strand Break Repair
Positive Regulation Of Peptidase Activity
Lymphoid Progenitor Cell Differentiation
Histone H2AXS139 Kinase Activity
Respiratory Electron Transport Chain
Electron Transport Chain
Aerobic Respiration
Aerobic Electron Transport Chain
Cellular Respiration
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
ATP Synthesis Coupled Electron Transport
Positive Regulation Of Signal Transduction By P53 Class Mediator
DNA Repair
Generation Of Precursor Metabolites And Energy
Macromolecule Metabolic Process
V(D)J Recombination
Proton Transmembrane Transport
Respiratory Chain Complex I
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Immunoglobulin V(D)J Recombination
Nonhomologous End Joining Complex
Protein Localization To Site Of Double-strand Break
Energy Derivation By Oxidation Of Organic Compounds
Extracellular Exosome
Response To Ionizing Radiation
DNA Metabolic Process
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Regulation Of Double-strand Break Repair
Telomere Maintenance
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Cytochrome-c Oxidase Activity
Proton Motive Force-driven Mitochondrial ATP Synthesis
Positive Regulation Of Chromosome Organization
Chromosome Organization
Protein Localization To Chromosome
Positive Regulation Of DNA Metabolic Process
Proton Motive Force-driven ATP Synthesis
ATP Metabolic Process
NADH Dehydrogenase Complex Assembly
Mitochondrial Respiratory Chain Complex I Assembly
Response To Radiation
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of DNA Repair
Positive Regulation Of Telomere Maintenance
Regulation Of Protein Metabolic Process
RNA Binding
NADH Dehydrogenase (ubiquinone) Activity
Regulation Of Cellular Response To Heat
DNA Recombination
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Tagcloud (Intersection)
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