CTSK and SPARC

Number of citations of the paper that reports this interaction (PMID 8647860)
31

Data Source:
HPRD (in vitro)

		CTSK	SPARC
Gene Name		cathepsin K	secreted protein, acidic, cysteine-rich (osteonectin)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endolysosome Lumen	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Collagen Binding Cysteine-type Peptidase Activity Proteoglycan Binding	Calcium Ion Binding Protein Binding Collagen Binding Extracellular Matrix Binding
	Biological Process	Intramembranous Ossification Toll-like Receptor Signaling Pathway Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Innate Immune Response Bone Resorption Proteolysis Involved In Cellular Protein Catabolic Process	Ossification Negative Regulation Of Endothelial Cell Proliferation Platelet Degranulation Receptor-mediated Endocytosis Signal Transduction Heart Development Blood Coagulation Response To Gravity Response To Lead Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Platelet Activation Extracellular Matrix Organization Lung Development Response To Lipopolysaccharide Response To L-ascorbic Acid Response To Cytokine Response To Peptide Hormone Response To Ethanol Response To Cadmium Ion Inner Ear Development Response To Glucocorticoid Response To CAMP Response To Calcium Ion Bone Development Cellular Response To Growth Factor Stimulus
Pathways		Toll-Like Receptors Cascades Trafficking and processing of endosomal TLR Collagen degradation Activation of Matrix Metalloproteinases MHC class II antigen presentation Degradation of the extracellular matrix Adaptive Immune System Innate Immune System	Scavenging by Class H Receptors Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)
Protein-Protein Interactions		6 interactors: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC	21 interactors: COL13A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 UBQLN1 VEGFA XRCC6 ZNF579
Entrez ID		1513	6678
HPRD ID		03064	01631
Ensembl ID		ENSG00000143387	ENSG00000113140
Uniprot IDs		P43235	P09486
PDB IDs		1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 7PCK	1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Somatic Stem Cell Maintenance Platelet Degranulation Regulation Of Endothelial Cell Proliferation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway DNA Ligation Involved In DNA Recombination Regulation Of Proteolysis Negative Regulation Of Epithelial Cell Proliferation Cell Activation Response To Wounding Stem Cell Maintenance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Inner Ear Development Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Activation Regulation Of Catalytic Activity Bone Development Ear Development Lagging Strand Elongation Pro-B Cell Differentiation Alveolar Secondary Septum Development Regulation Of Neuron Apoptotic Process Lung Development Axonogenesis Involved In Innervation Stem Cell Development Respiratory Tube Development Response To Abiotic Stimulus Response To Stimulus Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Establishment Of Integrated Proviral Latency Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Respiratory System Development Regulation Of Epithelial Cell Proliferation Regulation Of Neuron Death Immunoglobulin V(D)J Recombination Chondrocyte Proliferation Response To L-ascorbic Acid Establishment Of Viral Latency	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Wound Healing Platelet Activation Response To Wounding Blood Coagulation Hemostasis Collagen Catabolic Process Locomotion Blood Vessel Development Platelet Degranulation Organ Morphogenesis Vasculature Development Collagen Metabolic Process Regulation Of Body Fluid Levels Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cardiovascular System Development Response To Abiotic Stimulus Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Response To Hypoxia Cell Activation Tissue Development Response To Stress System Development Cellular Response To Growth Factor Stimulus Cell Migration Organ Development Bone Morphogenesis Response To Growth Factor Connective Tissue Development Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Collagen Fibril Organization Multicellular Organismal Development Anatomical Structure Development Vesicle-mediated Transport Endochondral Bone Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Exocytosis Response To Transforming Growth Factor Beta Skeletal System Development Regulation Of Blood Coagulation Positive Regulation Of Kidney Development Cartilage Development Involved In Endochondral Bone Morphogenesis Leukocyte Migration Developmental Process Bone Development
Tagcloud ?		alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth	aggregation chaperone chaperones combining concert culturing dependency divergent dnakj entirely ethanol exhibiting facilitated flask folding galactosidase grown hsps inoculation operon overexpressing overproduction pres2 prone shake simply supplementation upregulate yields
Tagcloud (Difference) ?		alkaline alp ccd cleidocranial cocultured ctr dental dspp dysplasia heterozygous interfered mineralization mineralized mmp9 mononuclear nodules ocn odontoblast opg osteoblast osteoclast partly pulp rankl remodeling retention runx2 teeth tooth	aggregation chaperone chaperones combining concert culturing dependency divergent dnakj entirely ethanol exhibiting facilitated flask folding galactosidase grown hsps inoculation operon overexpressing overproduction pres2 prone shake simply supplementation upregulate yields
Tagcloud (Intersection) ?