CTSK and SPARC

Number of citations of the paper that reports this interaction (PubMedID 8647860)
0

Data Source:
HPRD (in vitro)

		CTSK	SPARC
Description		cathepsin K	secreted protein acidic and cysteine rich
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endolysosome Lumen Lysosomal Lumen	Extracellular Region Basement Membrane Extracellular Space Cytoplasm Mitochondrion Plasma Membrane Cell Surface Nuclear Matrix Extracellular Matrix Platelet Alpha Granule Platelet Alpha Granule Membrane Platelet Alpha Granule Lumen Endocytic Vesicle Lumen
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Collagen Binding Metal Ion Binding Extracellular Matrix Binding
	Biological Process	Mitophagy Proteolysis Thyroid Hormone Generation Extracellular Matrix Disassembly Collagen Catabolic Process Bone Resorption Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Cartilage Development	Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Cell Morphogenesis Semicircular Canal Morphogenesis Regulation Of Synapse Organization
Pathways		Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Trafficking and processing of endosomal TLR MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	Platelet degranulation Nuclear signaling by ERBB4 ECM proteoglycans Scavenging by Class H Receptors
Drugs		[1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate Cyanamide 3-amino-5-phenylpentane N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide N-[(2S)-4-Methyl-1-oxo-1-{[(4S)-3-oxo-1-(2-pyridinylsulfonyl)-4-azepanyl]amino}-2-pentanyl]-1-benzofuran-2-carboxamide Dibenzyl (carbonylbis{2,1-hydrazinediyl[(2S)-4-methyl-1-oxo-1,2-pentanediyl]})biscarbamate N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide (2R)-2-(3-Biphenylyl)-N-{(2R)-2-hydroxy-3-[(2-pyridinylsulfonyl)amino]propyl}-4-methylpentanamide Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate MIV-701 Relacatib Odanacatib 1-{7-cyclohexyl-6-[4-(4-methylpiperazin-1-yl)benzyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}methanamine (2R)-3-Methyl-1-phenyl-2-butanyl [(2S)-1-oxo-2-hexanyl]carbamate 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE (1R,2R)-N-(2-Aminoethyl)-2-{[(4-methoxyphenyl)sulfonyl]methyl}cyclohexanecarboxamide TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE Balicatib MIV-711	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Pycnodysostosis
GWAS		Aspartate aminotransferase levels ( 33547301) Body mass index ( 26426971) Congenital left-sided heart lesions ( 26965164) Melanoma ( 21983785) Rhegmatogenous retinal detachment ( 23585552)	Stroke ( 32693751)
Interacting Genes		6 interacting genes: FGFR3 KNG1 LIG4 SERPINB13 SERPINB3 SPARC	26 interacting genes: COL11A1 COL13A1 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 CPEB2 CTSK FN1 HSPG2 PDGFA PDGFB PLAT PLG SDC2 TGFB1 TGM2 THBS1 TNC UBQLN1 VEGFA VHL XRCC6 ZNF579
Entrez ID		1513	6678
HPRD ID		03064	01631
Ensembl ID		ENSG00000143387	ENSG00000113140
Uniprot IDs		P43235	P09486
PDB IDs		1ATK 1AU0 1AU2 1AU3 1AU4 1AYU 1AYV 1AYW 1BGO 1BY8 1MEM 1NL6 1NLJ 1Q6K 1SNK 1TU6 1U9V 1U9W 1U9X 1VSN 1YK7 1YK8 1YT7 2ATO 2AUX 2AUZ 2BDL 2R6N 3C9E 3H7D 3KW9 3KWB 3KWZ 3KX1 3O0U 3O1G 3OVZ 4DMX 4DMY 4N79 4N8W 4X6H 4X6I 4X6J 4YV8 4YVA 5J94 5JA7 5JH3 5TDI 5TUN 5Z5O 6ASH 6HGY 6PXF 6QBS 6QL8 6QLM 6QLW 6QLX 6QM0 7NXL 7NXM 7PCK 7QBL 7QBM 7QBN 7QBO 8C3D	1BMO 1NUB 1SRA 2V53
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Negative Regulation Of Endopeptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Proteolysis Establishment Of Integrated Proviral Latency Negative Regulation Of Keratinocyte Apoptotic Process Serine-type Endopeptidase Inhibitor Activity Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Establishment Of Viral Latency Protease Binding Positive Regulation Of Hydrolase Activity Positive Regulation Of Phospholipase Activity Bone Maturation Regulation Of Catalytic Activity Extracellular Space Negative Regulation Of Protein Metabolic Process DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of Protein Metabolic Process Negative Regulation Of Catalytic Activity Fibroblast Growth Factor Receptor Activity Regulation Of Cell Population Proliferation Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Lipase Activity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Regulation Of Keratinocyte Apoptotic Process Autocrine Signaling Negative Regulation Of JUN Kinase Activity Paracrine Signaling Positive Regulation Of Endopeptidase Activity Semicircular Canal Morphogenesis BBSome Endochondral Bone Growth Positive Regulation Of Cell Population Proliferation Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Positive Regulation Of Peptidase Activity Lymphoid Progenitor Cell Differentiation	Extracellular Matrix Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Region Extracellular Matrix Structural Constituent Collagen Trimer Platelet Alpha Granule Lumen Proteoglycan Binding Anatomical Structure Morphogenesis Extracellular Space Extracellular Matrix Organization Extracellular Structure Organization Basement Membrane Animal Organ Morphogenesis Collagen Fibril Organization Anatomical Structure Formation Involved In Morphogenesis Response To Oxygen Levels Animal Organ Development Response To Hypoxia Protease Binding Angiogenesis Response To Decreased Oxygen Levels Regulation Of Blood Vessel Endothelial Cell Migration Collagen Type XI Trimer Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Blood Coagulation Regulation Of Hemostasis Blood Vessel Development Integrin Binding Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Cell Adhesion Regulation Of Locomotion Platelet-derived Growth Factor Receptor Signaling Pathway Developmental Process Response To Stress Negative Regulation Of Cell Adhesion Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Golgi Lumen Regulation Of Endothelial Cell Migration Secretory Granule Cell Migration Regulation Of Developmental Process Response To Wounding Negative Regulation Of Fibrinolysis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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