APOBEC1 and UFSP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOBEC1	UFSP2
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 1	UFM1 specific peptidase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex	Nucleus Cytoplasm Endoplasmic Reticulum
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeUFMylase Activity
	Biological Process	MRNA Processing Lipid Metabolic Process Triglyceride Metabolic Process Response To Gamma Radiation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Regulation Of Cell Population Proliferation Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Transport Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation MRNA Stabilization Establishment Of Localization In Cell Negative Regulation Of Triglyceride Metabolic Process Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Proteolysis Blood Circulation Regulation Of Type II Interferon Production Ribosome Disassembly Regulation Of Intracellular Estrogen Receptor Signaling Pathway Rescue Of Stalled Ribosome Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 28552196) Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899)
Interacting Genes		16 interacting genes: A1CF APOBEC2 BAG4 CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2	4 interacting genes: APOBEC1 CAPN1 LIG4 LMO1
Entrez ID		339	55325
HPRD ID		02531	07741
Ensembl ID		ENSG00000111701	ENSG00000109775
Uniprot IDs		P41238	B3KRI4 Q9NUQ7
PDB IDs		6X91
Enriched GO Terms of Interacting Partners?		MRNA Modification Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Processing RNA Binding MRNA Editing Complex Chromosomal 5-methylcytosine DNA Demethylation Pathway Nucleic Acid Binding RNA Modification Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytidine To Uridine Editing Negative Regulation Of MRNA Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Processing Negative Regulation Of RNA Catabolic Process Base Conversion Or Substitution Editing RNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Intermediate Filament Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Gene Expression Cyclin D2-CDK6 Complex MRNA Splicing, Via Spliceosome Single-stranded RNA Binding Negative Regulation Of MRNA Modification Nucleus Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Nucleobase-containing Compound Metabolic Process MRNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin MRNA Stabilization DeUFMylase Activity Regulation Of Primary Metabolic Process Keratinization Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process RNA Stabilization MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression	Response To Gamma Radiation Regulation Of Cell Population Proliferation MRNA Editing Complex Response To Ionizing Radiation Calpain Complex Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Regulation Of T Cell Homeostatic Proliferation Chromosomal 5-methylcytosine DNA Demethylation Pathway Lipoprotein Biosynthetic Process Apolipoprotein B MRNA Editing Enzyme Complex NMDA Selective Glutamate Receptor Signaling Pathway Mammary Gland Involution Nucleotide-excision Repair, DNA Gap Filling DNA-dependent Protein Kinase-DNA Ligase 4 Complex Immunoglobulin V(D)J Recombination Nonhomologous End Joining Complex Metal Ion Binding Cytidine To Uridine Editing Cytidine Deaminase Activity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Calcium-dependent Cysteine-type Endopeptidase Activity Self Proteolysis Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Lymphoid Progenitor Cell Differentiation AMP Binding Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Triglyceride Metabolic Process Low-density Lipoprotein Particle Clearance Cellular Response To Lithium Ion Lipoprotein Transport Base Conversion Or Substitution Editing Response To Radiation Response To Lithium Ion MRNA Modification Receptor Catabolic Process V(D)J Recombination Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response MRNA 3'-UTR AU-rich Region Binding Plasma Lipoprotein Particle Clearance Somatic Diversification Of Immunoglobulins Involved In Immune Response
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