APOBEC1

Description		apolipoprotein B mRNA editing enzyme catalytic subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding
	Biological Process	MRNA Processing Lipid Metabolic Process Triglyceride Metabolic Process Response To Gamma Radiation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Regulation Of Cell Population Proliferation Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Transport Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation MRNA Stabilization Establishment Of Localization In Cell Negative Regulation Of Triglyceride Metabolic Process Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 28552196) Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899)
Novel Interacting Genes		1 novel interacting genes: CACNA1I
Interacting Genes		16 interacting genes: A1CF APOBEC2 BAG4 CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2
Entrez ID		339
HPRD ID		02531
Ensembl ID		ENSG00000111701
Uniprot IDs		P41238
PDB IDs		6X91
Enriched GO Terms of Interacting Partners?		MRNA Modification Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Processing RNA Binding MRNA Editing Complex Chromosomal 5-methylcytosine DNA Demethylation Pathway Nucleic Acid Binding RNA Modification Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytidine To Uridine Editing Negative Regulation Of MRNA Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Processing Negative Regulation Of RNA Catabolic Process Base Conversion Or Substitution Editing RNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Intermediate Filament Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Gene Expression Cyclin D2-CDK6 Complex MRNA Splicing, Via Spliceosome Single-stranded RNA Binding Negative Regulation Of MRNA Modification Nucleus Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Nucleobase-containing Compound Metabolic Process MRNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin MRNA Stabilization DeUFMylase Activity Regulation Of Primary Metabolic Process Keratinization Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process RNA Stabilization MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression
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