APOBEC1 and CELF2

Number of citations of the paper that reports this interaction (PubMedID 11577082)
0

Data Source:
HPRD (in vitro, in vivo)

		APOBEC1	CELF2
Description		apolipoprotein B mRNA editing enzyme catalytic subunit 1	CUGBP Elav-like family member 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Apolipoprotein B MRNA Editing Enzyme Complex MRNA Editing Complex	Nucleus Nucleoplasm Cytoplasm Flemming Body Ribonucleoprotein Complex
	Molecular Function	RNA Binding Catalytic Activity Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MRNA 3'-UTR AU-rich Region Binding Metal Ion Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Pre-mRNA Binding
	Biological Process	MRNA Processing Lipid Metabolic Process Triglyceride Metabolic Process Response To Gamma Radiation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytidine To Uridine Editing MRNA Modification Low-density Lipoprotein Particle Clearance Regulation Of Cell Population Proliferation Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Transport Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation MRNA Stabilization Establishment Of Localization In Cell Negative Regulation Of Triglyceride Metabolic Process Chromosomal 5-methylcytosine DNA Demethylation Pathway Regulation Of MRNA Metabolic Process Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splice Site Recognition RNA Processing MRNA Processing Regulation Of Heart Contraction
Pathways		mRNA Editing: C to U Conversion Formation of the Editosome
Drugs		Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Body mass index ( 28552196) Creatine kinase levels ( 29403010) HDL cholesterol levels ( 28334899)	Activity variability during wake ( 33075057) Adult body size ( 32376654) Adventurousness ( 30643258) Adverse response to drug ( 30420678) Age at first sexual intercourse ( 34211149) Allergic rhinitis ( 30013184) Asthma ( 29273806 34103634) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Basal cell carcinoma ( 33549134) Body size at age 10 ( 32376654) Breastfeeding duration ( 25475840) Chronic kidney disease ( 31015462) Cognitive function in longevity ( 33607172) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 33627673) Glycemic traits (pleiotropy) ( 31021400) Liver enzyme levels (alanine transaminase) ( 24124411) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean platelet volume ( 32888494) Motion sickness ( 25628336) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Response to lamotrigine in genetic generalized epilepsy ( 32308125) Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		16 interacting genes: A1CF APOBEC2 BAG4 CDK6 CELF2 DNAJB11 DND1 HNRNPF HNRNPK KPNA2 KRTAP19-5 KRTAP6-1 KRTAP6-2 NOTO SYNCRIP UFSP2	23 interacting genes: A1CF APOBEC1 APP CEBPA ELAVL1 MIR140 MIR155 MIR18B MIR199A1 MIR19A MIR19B1 MIR205 MIR21 MIR29C MIR34B MIR363 MIR7-1 MIR9-2 MIRLET7I PCBP1 PTGS2 RNF10 TRAF3
Entrez ID		339	10659
HPRD ID		02531	03964
Ensembl ID		ENSG00000111701	ENSG00000048740
Uniprot IDs		P41238	A0A0J9YX66 A0A0J9YXJ0 A0A1B0GU44 A0A1B0GUN8 B4DDE7 B4DIB6 B4DT00 B4DZ01 E9PC62 O95319
PDB IDs		6X91	2MY7 2MY8 4LJM 4LMZ 4TLQ 5M8I
Enriched GO Terms of Interacting Partners?		MRNA Modification Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Metabolic Process MRNA Processing RNA Binding MRNA Editing Complex Chromosomal 5-methylcytosine DNA Demethylation Pathway Nucleic Acid Binding RNA Modification Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytidine To Uridine Editing Negative Regulation Of MRNA Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Processing Negative Regulation Of RNA Catabolic Process Base Conversion Or Substitution Editing RNA Metabolic Process Nucleic Acid Metabolic Process Ribonucleoprotein Complex Intermediate Filament Spliceosomal Complex Regulation Of RNA Splicing Positive Regulation Of Gene Expression Cyclin D2-CDK6 Complex MRNA Splicing, Via Spliceosome Single-stranded RNA Binding Negative Regulation Of MRNA Modification Nucleus Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Nucleobase-containing Compound Metabolic Process MRNA Binding Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin MRNA Stabilization DeUFMylase Activity Regulation Of Primary Metabolic Process Keratinization Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process RNA Stabilization MRNA Localization Resulting In Post-transcriptional Regulation Of Gene Expression	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression RISC Complex MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Developmental Process Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Regulation Of Cardiac Muscle Hypertrophy Regulation Of Defense Response Regulation Of Inflammatory Response Regulation Of Cytokine Production Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Muscle Cell Differentiation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Extracellular Vesicle Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Regulation Of MRNA Metabolic Process Regulation Of MRNA Stability MRNA Destabilization Negative Regulation Of Cell Migration Regulation Of Endothelial Cell Migration MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cell Population Proliferation RNA Destabilization Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Regulation Of RNA Stability Regulation Of Developmental Process Regulation Of Cell Population Proliferation
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