HNRNPC and PALB2

Number of citations of the paper that reports this interaction (PMID 23585894)
0

Data Source:
BioGRID (biochemical, unspecified method)

		HNRNPC	PALB2
Gene Name		heterogeneous nuclear ribonucleoprotein C (C1/C2)	partner and localizer of BRCA2
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Spliceosomal Complex Cytosol Membrane Protein Complex Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleoplasm
	Molecular Function	Nucleotide Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Poly(A) RNA Binding	DNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Splicing Gene Expression ATP-dependent Chromatin Remodeling 3'-UTR-mediated MRNA Stabilization	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation DNA Repair Mesoderm Development Organ Morphogenesis Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Fanconi Anemia pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 21738484)	Bipolar disorder ( 17554300)
Protein-Protein Interactions		48 interactors: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 BTRC CCDC85B CDKN2A CELF1 CSNK1A1 CSNK2A1 CSNK2A2 DHX9 EPS8 ERG FAS FXR2 GRB2 HNRNPD IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KRAS LMO2 LMO3 PALB2 PDGFB PHKB PIN1 PRKDC PTBP2 RAD51 RALY RALYL RBM41 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 UBE2I YWHAQ ZFYVE26 ZNF581	3 interactors: BRCA2 HNRNPC RAD51AP1
Entrez ID		3183	79728
HPRD ID		01243	07966
Ensembl ID		ENSG00000092199	ENSG00000083093
Uniprot IDs		P07910	Q86YC2
PDB IDs		1TXP 1WF2 3LN4	2W18 3EU7
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Nitrogen Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stimulus Cell Cycle Double-strand Break Repair Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Cell Cycle Cellular Response To Organic Substance MRNA Processing DNA Repair Cellular Response To Cytokine Stimulus Regulation Of Cellular Process Response To Stimulus Positive Regulation Of Signal Transduction Cellular Response To DNA Damage Stimulus Cellular Response To Stress DNA Metabolic Process Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression DNA Recombination Response To Cytokine Regulation Of Protein Metabolic Process MRNA Metabolic Process Response To Organic Substance Regulation Of Cellular Component Organization Response To Ionizing Radiation Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Developmental Process Positive Regulation Of Cellular Metabolic Process NLS-bearing Protein Import Into Nucleus RNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Mitotic Cell Cycle	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Ionizing Radiation Double-strand Break Repair DNA Recombination Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Replication Fork Protection Response To Radiation 3'-UTR-mediated MRNA Stabilization Response To UV-C DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Modification Regulation Of Mammary Gland Epithelial Cell Proliferation Chromatin Organization Inner Cell Mass Cell Proliferation Oocyte Maturation MRNA Stabilization Regulation Of Double-strand Break Repair Blastocyst Growth Cellular Response To DNA Damage Stimulus Male Meiosis I Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To X-ray Centrosome Duplication Chromosome Organization Histone H3 Acetylation Oocyte Development DNA Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Oocyte Differentiation Negative Regulation Of DNA Replication Response To Abiotic Stimulus Histone H4 Acetylation Response To Gamma Radiation Regulation Of MRNA Stability Regulation Of RNA Stability Centrosome Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cytokinesis Cellular Response To Ionizing Radiation Male Meiosis Regulation Of DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of DNA Recombination ATP-dependent Chromatin Remodeling Cell Aging
Tagcloud ?		17th 2d appreciation coordinately coupling d deep dihydroxyvitamin entitled epigenome exerts expanded extra fine hormones issue linking locations microrna ribonucleoprotein special splicing steroid transcriptionally tuning vdr vdre vitamin workshop	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		17th 2d appreciation coordinately coupling d deep dihydroxyvitamin entitled epigenome exerts expanded extra fine hormones issue linking locations microrna ribonucleoprotein special splicing steroid transcriptionally tuning vdr vdre vitamin workshop	alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?