HNRNPC and RALYL

Number of citations of the paper that reports this interaction (PubMedID 38334954)
77

Data Source:
BioGRID (cross-linking study)
HPRD (two hybrid)

		HNRNPC	RALYL
Description		heterogeneous nuclear ribonucleoprotein C	RALY RNA binding protein like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Reader Activity	Nucleic Acid Binding RNA Binding Protein Binding Identical Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Remodeling MRNA Processing RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase 3'-UTR-mediated MRNA Stabilization
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 21738484 31043756) Height ( 31562340)	Adult body size ( 32376654) Body mass index ( 25673413 28892062) Diastolic blood pressure ( 27841878) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Systolic blood pressure ( 27841878) Trunk fat mass ( 28552196)
Interacting Genes		59 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 DLG4 EPS8 ERG ESR1 FAS FXR2 GRB2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MAPT MEOX2 NUFIP2 OGT PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALYL RBM41 RBPMS2 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I USP7 WEE2-AS1 YWHAE YWHAQ ZFYVE26 ZNF581	25 interacting genes: ADISSP AEBP2 AEN BYSL CAMK2A CCDC85B CEP170P1 EWSR1 EXOSC7 FXR1 FXR2 HNRNPC LMO3 LRRK2 MBD2 MCRS1 NXF1 PCBP2 PSMF1 RBM41 THAP1 TIGD3 TSC1 TSNAX ZNF408
Entrez ID		3183	138046
HPRD ID		01243	11236
Ensembl ID		ENSG00000092199	ENSG00000184672
Uniprot IDs		P07910	B3KT61 Q86SE5
PDB IDs		1TXP 1WF2 2MXY 2MZ1 3LN4
Enriched GO Terms of Interacting Partners?		Nuclear Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of RNA Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Regulation Of Cell Communication Regulation Of Signaling BRCA1-B Complex DNA Metabolic Process DNA Repair DNA Recombination Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Nuclear Body Organization Double-strand Break Repair Via Homologous Recombination Regulation Of Macromolecule Biosynthetic Process Recombinational Repair Nuclear Import Signal Receptor Activity Cytosol Regulation Of DNA Metabolic Process Nuclear Localization Sequence Binding Regulation Of Cell Cycle Process Regulation Of DNA Damage Checkpoint Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus Regulation Of Cellular Response To Stress Cellular Component Assembly PML Body Cytoplasm Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus	Nucleic Acid Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleus RNA Binding MRNA Binding Negative Regulation Of Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Nucleolus Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Translation Regulator Activity Cytoplasmic Stress Granule Nucleoplasm Regulation Of RNA Metabolic Process Protein Homodimerization Activity Poly(U) RNA Binding Identical Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Nucleobase-containing Compound Metabolic Process MRNA 3'-UTR Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening MRNA 3'-UTR AU-rich Region Binding MRNA Transport Regulation Of Primary Metabolic Process RNA Processing Negative Regulation Of Hydrolase Activity Peptidyl-threonine Autophosphorylation Neuron Projection Negative Regulation Of Telomere Maintenance Memory T Cell Differentiation Negative Regulation Of Macroautophagy RNA Transport Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Nucleosomal DNA Binding Presynaptic Modulation Of Chemical Synaptic Transmission Nucleolus Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of MRNA Stability U12 SnRNA Binding
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