HNRNPC and BRIP1

Number of citations of the paper that reports this interaction (PubMedID 23585894)
44

Data Source:
BioGRID (unspecified method)

		HNRNPC	BRIP1
Description		heterogeneous nuclear ribonucleoprotein C	BRCA1 interacting DNA helicase 1
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GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Replication Fork Cytoplasm Nuclear Membrane BRCA1-B Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Reader Activity	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Remodeling MRNA Processing RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase 3'-UTR-mediated MRNA Stabilization	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Homologous Chromosome Pairing At Meiosis Spermatogenesis Spermatogonial Cell Division Spermatid Development Male Gonad Development Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Homologous Recombination Interstrand Cross-link Repair Chiasma Assembly Seminiferous Tubule Development Protein-DNA Covalent Cross-linking Repair Double-strand Break Repair Involved In Meiotic Recombination
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle	Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Fanconi anemia
GWAS		Bipolar disorder ( 21738484 31043756) Height ( 31562340)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		59 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 DLG4 EPS8 ERG ESR1 FAS FXR2 GRB2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MAPT MEOX2 NUFIP2 OGT PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALYL RBM41 RBPMS2 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I USP7 WEE2-AS1 YWHAE YWHAQ ZFYVE26 ZNF581	10 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HSD17B14 RPA1 SIRT1 TOPBP1
Entrez ID		3183	83990
HPRD ID		01243	05797
Ensembl ID		ENSG00000092199	ENSG00000136492
Uniprot IDs		P07910	A0A804HJU1 A0A804HL36 J3QKX0 Q9BX63
PDB IDs		1TXP 1WF2 2MXY 2MZ1 3LN4	1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?		Nuclear Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of RNA Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Regulation Of Cell Communication Regulation Of Signaling BRCA1-B Complex DNA Metabolic Process DNA Repair DNA Recombination Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Nuclear Body Organization Double-strand Break Repair Via Homologous Recombination Regulation Of Macromolecule Biosynthetic Process Recombinational Repair Nuclear Import Signal Receptor Activity Cytosol Regulation Of DNA Metabolic Process Nuclear Localization Sequence Binding Regulation Of Cell Cycle Process Regulation Of DNA Damage Checkpoint Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus Regulation Of Cellular Response To Stress Cellular Component Assembly PML Body Cytoplasm Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus	Recombinational Repair Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination DNA Repair Response To Ionizing Radiation Male Germ Cell Nucleus Lateral Element Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling P53 Binding DNA Metabolic Process Response To Radiation DNA Recombination DNA Damage Response DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle PML Body Chromatin Organization Negative Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Condensed Chromosome BRCA1-B Complex Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Condensed Nuclear Chromosome Cellular Response To Radiation Cellular Response To Stress Mitotic G2/M Transition Checkpoint Nucleoplasm Damaged DNA Binding Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Deacetylase Activity Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Random Inactivation Of X Chromosome Peptidyl-lysine Acetylation Protein Deacetylation Protein Lysine Deacetylase Activity DNA Repair Complex Regulation Of Cellular Response To Heat Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin-protein Adaptor Activity Histone Deacetylase Activity Regulation Of Cell Cycle
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