HNRNPC and KPNA5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HNRNPC	KPNA5
Description		heterogeneous nuclear ribonucleoprotein C	karyopherin subunit alpha 5
Image
GO Annotations	Cellular Component	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Reader Activity	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Remodeling MRNA Processing RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase 3'-UTR-mediated MRNA Stabilization	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport
Pathways		SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 21738484 31043756) Height ( 31562340)	Early cardiac repolarization ( 31600170) Telomere length ( 21460395)
Interacting Genes		59 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 DLG4 EPS8 ERG ESR1 FAS FXR2 GRB2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MAPT MEOX2 NUFIP2 OGT PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALYL RBM41 RBPMS2 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I USP7 WEE2-AS1 YWHAE YWHAQ ZFYVE26 ZNF581	29 interacting genes: ANP32A ANP32B ARNT ATM ATOSB BRMS1 CDKN1B CFTR DCPS EPAS1 FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326
Entrez ID		3183	3841
HPRD ID		01243	05179
Ensembl ID		ENSG00000092199	ENSG00000196911
Uniprot IDs		P07910	A0A8V8TL88 A0A8V8TMV2 O15131
PDB IDs		1TXP 1WF2 2MXY 2MZ1 3LN4	4U2X
Enriched GO Terms of Interacting Partners?		Nuclear Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of RNA Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Regulation Of Cell Communication Regulation Of Signaling BRCA1-B Complex DNA Metabolic Process DNA Repair DNA Recombination Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Nuclear Body Organization Double-strand Break Repair Via Homologous Recombination Regulation Of Macromolecule Biosynthetic Process Recombinational Repair Nuclear Import Signal Receptor Activity Cytosol Regulation Of DNA Metabolic Process Nuclear Localization Sequence Binding Regulation Of Cell Cycle Process Regulation Of DNA Damage Checkpoint Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus Regulation Of Cellular Response To Stress Cellular Component Assembly PML Body Cytoplasm Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus	Nucleoplasm Nucleus Negative Regulation Of DNA Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Catabolic Process Regulation Of Gene Expression Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Multicellular Organismal Process DNA Double-strand Break Processing Embryonic Placenta Development Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Apoptotic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macroautophagy Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Chromatin Negative Regulation Of Double-strand Break Repair Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA Repair MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Histone Deacetylase Binding Regulation Of Protein Modification Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Negative Regulation Of DNA Recombination Positive Regulation Of Hormone Biosynthetic Process DNA-binding Transcription Factor Activity
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