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UHRF2 and RAD51
Number of citations of the paper that reports this interaction (PubMedID
21952639
)
85
Data Source:
BioGRID
(far western blotting)
UHRF2
RAD51
Description
ubiquitin like with PHD and ring finger domains 2
RAD51 recombinase
Image
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
Chromosome
Pericentric Heterochromatin
Nuclear Ubiquitin Ligase Complex
Nuclear Chromosome
Chromosome, Telomeric Region
Chromatin
Condensed Chromosome
Condensed Nuclear Chromosome
Lateral Element
Male Germ Cell Nucleus
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Centrosome
Cytosol
Cytoskeleton
PML Body
Protein-containing Complex
Site Of Double-strand Break
Perinuclear Region Of Cytoplasm
Presynaptic Intermediate Filament Cytoskeleton
Molecular Function
DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
SUMO Transferase Activity
Histone Binding
Metal Ion Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Ubiquitin Protein Ligase Activity
Histone H3K9me2/3 Reader Activity
DNA Strand Exchange Activity
Nucleotide Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Single-stranded DNA Helicase Activity
Enzyme Binding
Identical Protein Binding
DNA Polymerase Binding
ATP-dependent DNA Damage Sensor Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Protein Ubiquitination
Protein Sumoylation
Cell Differentiation
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Regulation Of Cell Cycle
Protein Autoubiquitination
Telomere Maintenance Via Recombination
Double-strand Break Repair Via Homologous Recombination
DNA Recombinase Assembly
DNA Metabolic Process
DNA Repair
DNA Recombination
Mitotic Recombination
DNA Damage Response
Meiosis I
Reciprocal Meiotic Recombination
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To X-ray
Regulation Of Double-strand Break Repair Via Homologous Recombination
Telomere Maintenance Via Telomere Lengthening
Replication Fork Processing
Telomere Organization
Interstrand Cross-link Repair
DNA Strand Invasion
Meiotic Cell Cycle
Chromosome Organization Involved In Meiotic Cell Cycle
Cellular Response To Alkaloid
Cellular Response To Ionizing Radiation
Cellular Response To Gamma Radiation
Cellular Response To Hydroxyurea
Cellular Response To Cisplatin
Cellular Response To Camptothecin
Response To Glucoside
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Mitotic Recombination-dependent Replication Fork Processing
Double-strand Break Repair Involved In Meiotic Recombination
Regulation Of DNA Damage Checkpoint
Pathways
SUMOylation of transcription cofactors
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Transcriptional Regulation by E2F6
Meiotic recombination
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Amuvatinib
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31619474
31959851
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Periodontal microbiota (
22699663
)
Anxiety and stress-related disorders (
31116379
)
Hip circumference adjusted for BMI (
34021172
)
Malaria (
31844061
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Interacting Genes
42 interacting genes:
ATR
ATXN1
BAX
BCAR1
BCL2L1
CCND1
CD27
CDK1
CDK2
CDK4
CDK6
CTNNB1
DESI1
FANCD2
FYN
H3C1
HMGB1
HMGB2
JAK3
LCK
LYN
MCL1
PCNP
PTPRC
RAD51
RBCK1
RUNX1
SKP1
SMAD4
TP53
TRIM27
TRIM8
UBE2D1
UBE2D2
UBE2D4
UBE2K
UBE2W
UHRF1
XRCC1
YY1
ZNF410
ZNF618
99 interacting genes:
ABL1
AGO2
ATM
ATRX
BARD1
BCCIP
BCR
BLM
BRCA1
BRCA2
CASP3
CASP7
CASP8AP2
CCND1
CDH13
CHD3
CHEK1
CRYAA
CSNK2A1
CSNK2B
CST6
CTCF
DDB2
DMC1
DNAJA3
ENAH
EP400
ERCC2
ERCC5
EVL
FANCD2
FANCI
FBH1
FBXO5
FIRRM
GMEB1
HID1
HNRNPC
HSP90AA1
IL24
IRS1
ITIH5
MAPK8IP3
MCPH1
MDC1
MMS22L
MSH4
NBN
NCL
NELFB
NXF1
PARPBP
PCSK1N
PDS5B
PFN1
PIAS1
PLK1
POLA1
RAD18
RAD51AP1
RAD51AP2
RAD51C
RAD52
RAD54B
RAD54L
RAD54L2
RECQL5
RELA
RFWD3
RNF20
RPA1
RPA2
RPA3
SEM1
SFR1
SIRT2
ST14
SUMO1
SUMO2
SWSAP1
TDG
TFF1
TOPORS
TP53
TP53BP1
UBE2I
UCHL3
UGDH
UHRF2
UMPS
USP10
VASP
VIM
WDR48
WRN
XPO1
XRCC2
XRCC3
ZDHHC17
Entrez ID
115426
5888
HPRD ID
18257
01557
Ensembl ID
ENSG00000147854
ENSG00000051180
Uniprot IDs
Q96PU4
Q06609
PDB IDs
1WY8
1Z6U
2E6S
3OLN
4PW5
4PW6
4PW7
4TVR
5YCO
1B22
1N0W
5H1B
5H1C
5JZC
5NP7
5NWL
7C9A
7EJC
7EJE
8BQ2
8BR2
8BSC
8GYK
8JND
8JNE
8JNF
8PBC
8PBD
8R64
8RCD
8RCF
8XBT
8XBU
8XBV
8XBW
8XBX
8XBY
Enriched GO Terms of Interacting Partners
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DNA Damage Response
Response To Gamma Radiation
Post-translational Protein Modification
Nucleus
Regulation Of Apoptotic Process
Protein Modification Process
Regulation Of Programmed Cell Death
Chromosome Organization
Lymphocyte Activation
Cellular Response To Stress
Macromolecule Metabolic Process
Regulation Of Metabolic Process
Protein Polyubiquitination
Protein Ubiquitination
Regulation Of Multicellular Organismal Development
Negative Regulation Of Metabolic Process
Response To Ionizing Radiation
DNA Repair
Double-strand Break Repair
Cell Activation
Response To Stress
Positive Regulation Of Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Damage Checkpoint Signaling
Regulation Of Macromolecule Metabolic Process
Regulation Of Hemopoiesis
Regulation Of Cell Development
Positive Regulation Of Programmed Cell Death
Protein Modification By Small Protein Conjugation
Leukocyte Activation
Intracellular Signal Transduction
Regulation Of Primary Metabolic Process
Response To Alcohol
Signal Transduction
Extrinsic Apoptotic Signaling Pathway
Regulation Of Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Macromolecule Metabolic Process
Ubiquitin Conjugating Enzyme Activity
Regulation Of DNA Metabolic Process
Leukocyte Differentiation
Condensed Chromosome
Regulation Of Apoptotic Signaling Pathway
Regulation Of T Cell Activation
Response To Xenobiotic Stimulus
Transferase Activity
T Cell Activation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Differentiation
Cell Surface Receptor Signaling Pathway
DNA Repair
DNA Damage Response
DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Double-strand Break Repair
Recombinational Repair
Cellular Response To Stress
DNA Recombination
Nucleoplasm
Nucleic Acid Metabolic Process
Nucleobase-containing Compound Metabolic Process
Response To Stress
Macromolecule Metabolic Process
Nucleus
PML Body
Signal Transduction In Response To DNA Damage
Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of DNA Metabolic Process
Regulation Of DNA Recombination
Replication Fork
Regulation Of Cell Cycle
Single-stranded DNA Binding
Response To Ionizing Radiation
DNA Binding
DNA Damage Checkpoint Signaling
Response To Radiation
Regulation Of DNA Repair
Mitotic DNA Damage Checkpoint Signaling
Regulation Of Cell Cycle Process
Regulation Of Double-strand Break Repair
Chromosome Organization
Mitotic DNA Integrity Checkpoint Signaling
Chromosome
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Damaged DNA Binding
Negative Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cellular Response To Stress
Negative Regulation Of Cell Cycle Process
Site Of Double-strand Break
Homologous Recombination
Negative Regulation Of DNA Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Chromosome, Telomeric Region
Response To X-ray
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Regulation Of Primary Metabolic Process
Negative Regulation Of DNA Recombination
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Tagcloud (Difference)
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Tagcloud (Intersection)
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